Anti-thyroid autoimmunity and psychic disorders*

Полина Соболевская; Тамара Федоткина; Антон Гвоздетский; Евгения  Ефимова; Юрий Строев; Владимир Утехин; Леонид Чурилов

doi:10.21638/spbu11.2019.407

Авторы

Полина Соболевская St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Тамара Федоткина St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 44, pr. Thoreza, St. Petersburg, 194223, Russian Federation
Антон Гвоздетский St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Евгения Ефимова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Юрий Строев St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Владимир Утехин St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Леонид Чурилов St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian FederationжSaint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, 2–4, Ligovsky pr., St. Petersburg, 191036, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.407

Аннотация

Thyroid hormones are essential for normal brain development and function, also regulatingsome processes in im mune system. The vicious effect of hypothyroidism for central nervous system displayed in myxoedema is known for many decades, but there is a CNS disorder related to autoimmune thyroid disease and not merely dependent on hypothyroidism. That is Hashimoto’s encephalopathy (steroid-responsive encephalopathy of autoimmune thyroiditis) — an enigmatic combination of cognitive, mood and motor disorders with psychotic symptoms, which pathogenesis is still unclear. The article describes natural history of this entity, its epidemiology, clinical and laboratory manifestation, and compares several existing theories of its pathogenesis with appropriate pros and contras. Vascular, dyshormonal and non-vascular autoimmune links of Hashimoto’s encephalopathy pathogenesis are discussed in intermingled discourse. The attempt to construct a synthetic concept of Hashimoto’s encephalopathy pathogenesis is given. The experience of authors based on investigation of clinical, endocrine and immunological parameters of 17 cases of autoimmune thyroiditis with schizophrenia-like manifestations is described, correlations are explored between immunoendocrine and psychic manifestations of disease

Ключевые слова:

autoantibodies, Hashimoto’s thyroiditis, Hashimoto’s encephalopathy, steroidresponsive encephalopathy associated with autoimmune thyroiditis, schizophrenia, autoimmune encephalitis, psychosis

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References

Castillo P. et al. Steroid-responsive encephalopathy associated with autoimmune thyroiditis, Arch.Neurol ., 2006, no. 63, pp. 197–202.

Curling T.B. Two cases of absence of the thyroid body, and symmetrical swellings of fat tissue at the sides of the neck, connected with defective cerebral development. Medico-Surgical Transact, 1850, no. 33, pp. 303–306.

Fernández-Lamo I., Montero-Pedrazuela A., Delgado-García J.M. et al. Effects of thyroid hormone replacement on associative learning and hippocampal synaptic plasticity in adult hypothyroid rats. Eur. J. Neurosci ., 2009, no. 30, pp. 679–692.

Koibuchi N., Fukuda H., Chin W.W. Promoter-specific regulation of the brain-derived neurotropic factor gene by thyroid hormone in the developing rat cerebellum. Endocrinology, 1999, no. 140,pp. 3955–3961.

Liu D., Teng W., Shan Z., Yu X., et al. The effect of maternal subclinical hypothyroidism during pregnancy on brain development in rat offspring. Thyroid., 2010, vol. 20, no. 8, pp. 909–915.

Neveu I., Arenas E. Neurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo. J.Cell. Biol., 1996, no. 133, pp. 631–646.

Sui L., Ren W.W., Li B.M. Administration of thyroid hormone increases reelin and brain-derived neurotrophic factor expression in rat hippocampus in vivo. Brain Res., 2010, no. 1313, pp. 9–24.

Monopoli M.P., Raghnaill M.N., Loscher J. S. et al. Temporal proteomic profile of memory consolidation in the rat hippocampal dentate gyrus.Proteomics, 2011, no. 11, pp. 4189–4201.

Mori Y., Tomonaga D., Kalashnikova A., Furuya F., Akimoto N., Ifuku M., Okuno Y., Beppu K., Fujita K., Katafuchi T., Shimura H., Churilov L.P., Noda M. Effects of 3,3’,5-triiodothyronine on microglial functions. Glia, 2015, vol. 63, no. 5, pp. 906–920.

Lord Brain W.B. et al. Hashimoto’s disease and encephalopathy. The Lancet, 1966, vol. 288, no. 7462,pp. 512–514.

Hashimoto H. Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa). Archiv Klin. Chir., 1912, no. 97, pp. 219–250.

Canton A., de Fabregas O., Tintore M. Encephalopathy associated to autoimmune thyroid disease: a more appropriate term for an underestimated condition? J.Neurol. Sci., 2000, no. 176, pp. 65–69.

Marshall G.A., Doyle J.J. Long-term treatment of Hashimoto`s encephalopathy. J.Neuropsychiatry Clin. Neurosci., 2006, no. 18, pp. 14–20.

Castillo P.R., Boeve B.F., Caselli J.R. et al. Steroid-responsive encephalopathy associated with thyroid autoimmunity: clinical and laboratory findings. Neurol. Supplement., 2002, vol. 3, p.A248.

Chaudhuri A., Behan P.O. The clinical spectrum, diagnosis, pathogenesis and treatment of Hashimoto’s encephalopathy (recurrent acute disseminated encephalomyelitis). Curr. Med. Chem., 2003, no. 10, pp. 1945–1953.

Chong J.Y., Rowland L.P., Utiger R.D. Hashimoto encephalopathy: syndrome or myth? Arch. Neurol., 2003, no. 60, pp. 164–171.

Ferracci F., Bertiato G., Moretto G. Hashimoto’s encephalopathy: epidemiologic data and pathogenetic considerations. J.Neurol. Sci., 2004, no. 217, pp. 165–168.

Churilov L.P., Sobolevskaia P.A., Stroev Y.I. Thyroid Gland and Brain: Enigma of Hashimoto’s Encephalopathy. Best Pract. & Res. Clin. Endocrinol. & Metab., 2019, vol. 34, no. 2, pp. 101364.