Anti-thyroid autoimmunity and psychic disorders*

Авторы

  • Полина Соболевская St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Тамара Федоткина St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 44, pr. Thoreza, St. Petersburg, 194223, Russian Federation
  • Антон Гвоздетский St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Евгения Ефимова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Юрий Строев St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Владимир Утехин St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Леонид Чурилов St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian FederationжSaint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, 2–4, Ligovsky pr., St. Petersburg, 191036, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.407

Аннотация

Thyroid hormones are essential for normal brain development and function, also regulatingsome processes in im mune system. The vicious effect of hypothyroidism for central nervous system displayed in myxoedema is known for many decades, but there is a CNS disorder related to autoimmune thyroid disease and not merely dependent on hypothyroidism. That is Hashimoto’s encephalopathy (steroid-responsive encephalopathy of autoimmune thyroiditis) — an enigmatic combination of cognitive, mood and motor disorders with psychotic symptoms, which pathogenesis is still unclear. The article describes natural history of this entity, its epidemiology, clinical and laboratory manifestation, and compares several existing theories of its pathogenesis with appropriate pros and contras. Vascular, dyshormonal and non-vascular autoimmune links of Hashimoto’s encephalopathy pathogenesis are discussed in intermingled discourse. The attempt to construct a synthetic concept of Hashimoto’s encephalopathy pathogenesis is given. The experience of authors based on investigation of clinical, endocrine and immunological parameters of 17 cases of autoimmune thyroiditis with schizophrenia-like manifestations is described, correlations are explored between immunoendocrine and psychic manifestations of disease

Ключевые слова:

autoantibodies, Hashimoto’s thyroiditis, Hashimoto’s encephalopathy, steroidresponsive encephalopathy associated with autoimmune thyroiditis, schizophrenia, autoimmune encephalitis, psychosis

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References

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Загрузки

Опубликован

15.06.2020

Как цитировать

Соболевская, П., Федоткина, Т., Гвоздетский, А., Ефимова, Е. ., Строев, Ю., Утехин, В., & Чурилов , Л. (2020). Anti-thyroid autoimmunity and psychic disorders*. Вестник Санкт-Петербургского университета. Медицина, 14(4), 288–291. https://doi.org/10.21638/spbu11.2019.407

Выпуск

Раздел

Неврология. Нейрохирургия. Психиатрия

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