Family cases of primary Sjogren’s syndrome in monozygous twins*

Authors

  • Alexandr Shishkin St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Natalia Basantsova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation https://orcid.org/0000-0002-2957-410X
  • Mikhail Erman St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Ludmila Slepykh St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.415

Abstract

Primary Sjogren’s disease is a systemic disorder of unknown origin with chronic autoimmune inflammation of the exocrine glands and the obligatory involvement of the salivary and lacrimal glands. We present the cases of primary Sjogren’s disease in monozygous twins. These concordant cases suggest the genetic determination of the disease. Early diagnosis of the disease and initiation of immunosuppressive therapy in patient A.prevented the serious complications. The effect of treatment was clearly visible with patient’s cancellation of the basic therapy for almost 6 years, after which the general condition worsened, and a joint pain developed. Long-term therapy with small doses of alkylating cytostatics and glucocorticosteroids positively affects systemic manifestations of the disease, and significantly improves the survival of patients. The presence of complications caused by glucocorticosteroid therapy should be taken into account.

Keywords:

Sjogren’s syndrome, Sicca syndrome, twins, concordance, xerostoma, xerophthalmia

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References


References

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Published

2020-06-15

How to Cite

Shishkin, A. ., Basantsova, N., Erman, M. ., & Slepykh, L. . (2020). Family cases of primary Sjogren’s syndrome in monozygous twins*. Vestnik of Saint Petersburg University. Medicine, 14(4), 318–321. https://doi.org/10.21638/spbu11.2019.415

Issue

Vol. 14 No. 4 (2019)

Section

Internal medicine

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.

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