IVF/ICSI efficiency in women with Hashimoto thyroiditis

Authors

  • Galina Safarian St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Alexander Gzgzyan St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation
  • Lyailya Dzhemlikhanova 1 St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0001-6842-4430
  • Dariko Niauri St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.431

Abstract

It is known that in women affected with thyroid autoimmunity, namely Hashimoto’s thyroiditis, the prevalence of infertility is very high and reaches 47%. The retrospective cohort study was performed to assess the effects of thyroid autoimmunity on IVF/ICSI outcomes in women with infertility due to tubal factor and verified autoimmune thyroiditis in status of euthyroidism. The present study confirms a negative impact of thyroid autoimmunity on the course of pregnancy achieved through IVF/ICSI. Thyroid autoimmunity does not appear to have an impact on IVF/ICSI outcome in terms of mean number of oocytes retrieved. However, fertilization, implantation and delivery rates were lower, and the risk of miscarriage was higher in the presence of anti-thyroperoxidase autoantibodies. Thus, thyroid autoanantibodies positivity even in euthyroid state should be considered an independent risk factor for pregnancy complications after IVF/ICSI treatment.

Keywords:

TPOAbs, ART, infertility, ovarian reserve, embryo qualit

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Author Biography

Lyailya Dzhemlikhanova, 1 St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation

 

References


References

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Perminova S.G. Infertility in women with thyroid disease: Principles of diagnosis, management. Akusherstvo i ginekologiia: Novosti. Mneniia. Obuchenie, 2013, no. 2, pp. 18–24. (In Russian)

Shoenfeld Y., Meroni P.L., Churilov L.P. (Eds). Guide in Autoimmune Diseases for General Medical Practice. St. Petersburg, ELBI-Medkniga Publ., 2017, pp. 298–323.

Quintino-Moro A., Zantut-Wittmann D.E., Tambascia M., Machado H.D.C., Fernandes A. High Prevalence of Infertility among Women with Graves’ Disease and Hashimoto’s Thyroiditis.Int. J. Endocrinol., 2014, vol. 2014, Article ID 982705.

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Published

2020-06-15

How to Cite

Safarian , G. ., Gzgzyan, A., Dzhemlikhanova, L., & Niauri , D. . (2020). IVF/ICSI efficiency in women with Hashimoto thyroiditis. Vestnik of Saint Petersburg University. Medicine, 14(4), 374–376. https://doi.org/10.21638/spbu11.2019.431

Issue

Vol. 14 No. 4 (2019)

Section

Obstetrics and ginecology

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.

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