CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM (VAL158MET) IN WOMEN WITH UTERINE LEIOMYOMA AND ADENOMYOSIS

Dariko  Niauri; Lyailya  Dzhemlikhanova; Alexandr  Gzgzyan; Natalia  Osinovskaya; Ekaterina  Gorovaya; Tatyana  Ivashchenko; Iskender Yu. Sultanov; Antoninatonya  Tkachenko

doi:10.21638/11701/spbu11.2016.310.

Authors

Dariko Niauri Saint Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Lyailya Dzhemlikhanova Saint Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Alexandr Gzgzyan Saint Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya linia, St. Petersburg, 199034, Russian Federation
Natalia Osinovskaya D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya linia, St. Petersburg, 199034, Russian Federation
Ekaterina Gorovaya Saint Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0003-0047-9026
Tatyana Ivashchenko D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya linia, St. Petersburg, 199034, Russian Federation
Iskender Yu. Sultanov D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya linia, St. Petersburg, 199034, Russian Federation
Antoninatonya Tkachenko Saint Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/11701/spbu11.2016.310.

Abstract

The aim of this research was to study the frequency of polymorphic variants Val158Met (rs4680) of catechol-O-methyltransferase (COMT) gene in patients with uterine leiomyoma. A polymerase chain reaction was performed to figure out the frequency of polymorphic alleles of COMT gene in 54 patients with uterine leiomyoma and 103 women from the general population. It is shown that the presence of the genotype G/G of the COMT gene is associated with 2.5 times-increased risk of uterine leiomyoma (RR 2,44, Cl95: 1,168-5,103) , whereas the genotype A/A is not associated with the development of leiomyoma. At the same time, a comparative analysis of the genotypes frequencies of the COMT gene polymorphism between groups with different combinations of hyperplastic processes of reproductive system (uterine leiomyoma, adenomyosis, hyperplastic processes of endometrium), showed no statistically significant differences. Refs 26. Tables 3.

Keywords:

fibroids, leiomyoma, adenomyosis, hyperplastic process of endometrium, catechol-omethyltransferase

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