HPV and cervical lesion spread type specificity in women of reproductive age in Saint Petersburg

Александр  Гзгзян; Ляиля  Джемлиханова; Маргарита Мартиросян; Дарико  Ниаури; Ольга Соколова; Галина Сафарян; Елене Бородина

doi:10.21638/spbu11.2019.305

Авторы

Александр Гзгзян St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation
Ляиля Джемлиханова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0003-1556-248X
Маргарита Мартиросян Center of Infectious Diseases and Prophylaxis, 179, nab. Obvodnogo kanala, St. Petersburg, 190103, Russian Federation
Дарико Ниаури St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ;D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0003-1556-248X
Ольга Соколова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federatio https://orcid.org/0000-0002-5723-4305
Галина Сафарян St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0001-5988-323X
Елене Бородина St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0002-7801-7123

DOI:

https://doi.org/10.21638/spbu11.2019.305

Аннотация

HIV infection is a risk factor for cervical cancer and both diseases show steady increase in Saint Petersburg. HIV-positive women are at greater risk of cervical dysplasia than HIV-negative women which may be as a result of immunosupression, hence adding more burdens to their already worsening health condition. The impact of highly active antiretroviral therapy (HAART) on HPV infection and cervical diseases associated with HPV remains uncertain. Type-specific prevalence of HR-HPV, risk factors for cervical precancer and cancer among Russian HIV-positive women were not previously estimated. The present study objective is determined by lack of HPV infection feature data as well as that of HPV-associated cervical disease, depending on HIV infection severity and HAART employment in HIV-infected St. Petersburg female population.

Ключевые слова:

HPV infection, immunosuppression, cervical dysplasia, HIV, HAART

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