ETIOPATHOGENETIC MECHANISMS OF DEVELOPMENT OF INFLAMMATORY PERIODONTAL DISEASES IN PATIENTS WITH OBESITY

Authors

  • Людмила Александровна Ермолаева St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Андрей Владимирович Севбитов I. M. Sechenov First Moscow State Medical University, 8, str. 2, Trubetskaya ul., Moscow, 119991, Russian Federation
  • Евгений Александрович Пеньковой t. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Александр Николаевич Шишкин t. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Наталья Александровна Шевелева St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Марина Анатольевна Шевелева St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Наталия Александровна Соколович St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Екатерина Станиславовна Михайлова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Ольга Витальевна Хабарова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/11701/spbu11.2017.407

Abstract

The article presents modern scientific data on etiopathogenesis and the relationship between obesity and inflammatory periodontal diseases, which represent a serious medical and social problem throughout the world. The results of the original research on this problem are presented, as well as the prospects for its further study. 153 patients (102 of them with obesity) participated in the study and used such methods as clinical and radiological examination of the condition of periodontal tissues,evaluation of the microcirculatory vascular bed of periodontal tissues and bone tissue of the jaw bones using the methods of ultrasonic dopplerography and ultrasonic densitometry. Comparing the severity of parodist pathology in the main and control groups by means of correlation analysis, significantdifferences between groups were obtained (p <0.0001). Data obtained as a  result of dopplerography of periodontal vessels showed an inverse correlation between the indices of the body mass index and the linear systolic blood flow velocity (r = –0.6754, p <0.001). Also, in the evaluation of densitometry, an inverse correlation was obtained between the indices of the body mass index and the density of bone tissue (r = –0.61, p <0.001). As a result of the analysis of the data obtained, it was concluded that there is an etiopathogenetic relationship between periodontal diseases and obesity. Understanding the peculiarities of the interference of these two diseases will facilitate the estimation of the prognosis in such patients, simplifying the choice of necessary therapy taking into account the effect on microcirculation and bone mineral density. Refs 40. Figs 2.

Keywords:

periodontitis, obesity, С-reactive protein, leptin, dislipidemia, ultrasonic densitometry, dopplerography of periodontal vessels

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References

Литература

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J. Ethnopharmacol., 2010, no. 132 (3), pp. 564–569.

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Sbordone L., Bortolaia C. Oral microbial biofilms and plaque-related diseases: microbial communities and their role in the shift from oral health to disease. Clinical Oral Investigations, 2003, no. 7, pp. 181–188.

Graves D. T., Fine D., Teng Y. T., Van Dyke T. E., Hajishengallis G. The use rodent models to investigate host-bacteria interactions related to periodontal diseases. J. Clin Periodontol., 2008, no. 35, pp. 89–105.

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Bansal T., Pandey A., Asthana A. K. C-Reactive Protein (CRP) and its Association with Periodontal

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Ramamoorthy R. D., Nallasamy V., Reddy R., Esther N. A review of C-reactive protein: A diagnostic indicator in periodontal medicine. J. Pharm Bioallied Sci., 2012, no. 4 (Suppl. 2), pp. 238–245.

Yoshi S., Tsuboi S., Morita I., Takami Y., Adachi K., Inukai J., Inagaki K., Mizuno K., Nakagaki H.

Temporal association of elevated C-reactive protein and periodontal disease in men. J. Periodontol., 2013, vol. 80 (5), pp. 734–739.

Vidal F., Figueredo C. M., Cordovil I., Fischer R. G. Periodontal therapy reduces plasma levels of

interleukin-6, C-reactive protein, and fibrinogen in patients with severe periodontitis and refractory arterial

hypertension. J. Periodontol., 2009, vol. 80 (5), pp. 786–791.

Kaustubh T., Vikas D., Manohar B. Evaluation of C-reactive protein serum levels in periodontitis

patients with or without atherosclerosis. Indian Journal of Dental Research, 2010, no. 21, pp. 326–329.

Deschner J., Nokhbehsaim M. Regulatory effects of inflammatory and biomechanical signals on

regenerative periodontal healing. International Journal of Oral & Maxillofacial Implants, 2013, no. 28,

pp. 472–477.

Ermolaeva L. A., Shishkin A. N., Sheveleva N. A., Sheveleva M. A., Pen’kovoi E. A. Ozhirenie i

zabolevaniia parodonta [Obesity and periodontal disease]. International scientific and practical conference

world science. Dubai, 2015, vol. 2, no. 3 (3), pp. 54–56. (In Russian)

Elter J. R., Catherine M. E., Offenbacher S., Beck J. D. Relationship of periodontal disease and tooth loss to prevalence of coronary heart disease. J. Periodontol., 2004, vol. 75 (6), pp. 782–790.

Marchetti E., Monaco А., Procaccini L., Mummolo S., Gatto R., Tetè S., Baldini A., Tecco S., Marzo G. Periodontal disease: the influence of metabolic syndrome. Nutrition & Metabolism, 2012, vol. 9 (1), p. 88.

Osazuwa F., Onoriode M. A., Adeolu A. A. Markers of inflammation among Nigerian periodontitis patients. Journal of Immunological Techniques in Infectious Diseases, 2014, vol. 3 (2), p. 32.

Preshaw P. M., Alba A. L., Herrera D., Jepsen S., Konstantinidis A., Makrilakis K., Taylor R.

Periodontitis and diabetes: a two-way relationship. Diabetologia, 2012, vol. 55 (1), p. 31.

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Jeemon P., Prabhakaran D., Ramakrishnan L., Ahmed F., Thankappan K., Kartha C., Chaturvedi V.,Reddy K. Association of high sensitive C-reactive protein (hsCRP) with established cardiovascular risk

factors in the Indian population. Nutr. Metab., 2011, vol. 8 (1), pp. 19–27.

Faucher G., Guénard F., Bouchard L., Garneau V., Turcot V., Houde A., Tchernof A., Bergeron J.,

Deshaies Y., Hould F. S., Lebel S., Marceau P., Vohl M. C. Genetic contribution to C-reactive protein levels in

severe obesity. Mol. Genet Metab., 2012, vol. 105 (3), pp. 494–501.

Weatherall D. J., Ledingham J. G., Warrell D. A. The acute phase response and C-reactive protein.

Oxford textbook of Medicine. Edition 3rd. N. Y., Oxford, 1996, pp. 1527–1533.

Saito T., Murakami M., Shimazaki Y., Oobayashi K., Matsumoto S., Koga T. Association between

alveolar bone loss and elevated serum C-reactive protein in Japanese men. J. Periodontol., 2003, vol. 74 (12),pp. 1741–1746.

Ay Z. Y., Kirziogg F. Y., Tonguc M. O., Su R., Kapucuoglu N. The gingiva contains leptin and leptin

receptor in health and disease. Odontology, 2012, no. 100, pp. 222–231.

Li W., Zhu W., Hou J., Huang B., Liu K., Meng H. Leptin and its receptor expression in dental and

periodontal tissues of primates. Cell and Tissue Research, 2014, no. 355, pp. 181–188.

Romanos G. E., Asnani K. P., Hingorani D., Desh-mukh V. L. PERIOSTIN: role in formation and

maintenance of dental tissues. Journal of Cellular Physiology, 2014, no. 229, pp. 1–5.

Jeemon P., Prabhakaran D., Ramakrishnan L., Gupta R., Ahmed F., Thankappan K. P., Kartha C. C.,Chaturvedi V., Reddy K. S. Association of high sensitive C-reactive protein (hsCRP) with established

cardiovascular risk factors in the Indian population. Nutr. Metab., 2011, vol. 8 (19), pp. 19–27.

Faucher G., Guénard F., Bouchard L., Garneau V., Turcot V., Houde A., Tchernof A., Bergeron J.,

Deshaies Y., Hould F. S., Lebel S., Marceau P., Vohl M. C. Genetic contribution to C-reactive protein levels in

severe obesity. Mol. Genet. Metab., 2012, vol. 105 (3), pp. 494–501.

Procaccini C., Jirillo E., Matarese G. Leptin as an immunomodulator. Molecular Aspects of Medicine,2012, no. 33, pp. 35–45.

Johnson R. B., Serio F. G. Leptin within healthy and diseased human gingiva. J.

Periodontol., 2001,no. 72, pp. 1254–1257.

Karthikeyan B. V., Pradeep A. R. Leptin levels in gingival crevicular fluid in periodontal health and

disease. Journal of Periodontal Research, 2007, vol. 42, no. 4, pp. 300–304.

Вестник Санкт-Петербургского университета. Медицина

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Published

2017-12-05

How to Cite

Ермолаева, Л. А., Севбитов, А. В., Пеньковой, Е. А., Шишкин, А. Н., Шевелева, Н. А., Шевелева, М. А., … Хабарова, О. В. (2017). ETIOPATHOGENETIC MECHANISMS OF DEVELOPMENT OF INFLAMMATORY PERIODONTAL DISEASES IN PATIENTS WITH OBESITY. Vestnik of Saint Petersburg University. Medicine, 12(4), 385–395. https://doi.org/10.21638/11701/spbu11.2017.407

Issue

Vol. 12 No. 4 (2017)

Section

Stomatology

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