Autoimmune aspects of pulmonary sarcoidosis*

Authors

  • Anna Starshinova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Leonid Churilov St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ;St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation
  • Gennadiy Ershov St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Yulia Zinchenko St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ;St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation
  • Piotr Yablonskiy St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ;St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.419

Abstract

Despite a plenty of pulmonologic studies, aetiology and pathogenesis of lung sarcoidosis are still insufficiently clear. Most researchers are inclined to speculate about the possible autoimmune/immune-mediated genesis of the disease, finding new evidence of such. The minireview attempted an integral analysis of currently available data suggesting autoimmune origin of sarcoidosis divided into four categories: The role of triggers in the development of sarcoidosis; the presence of immunogenetic susceptibility to the disease; analysis of cellular and humoral immunity in it and evaluation of clinical signs detected in sarcoidosis patients. New original definition of sarcoidosis is suggested. New data are reviewed on the possible autoinflammatory disorder of macrophageal polarization in sarcoidosis distinguishing it from tuberculosis. Author’s original hypothesis on possible therapeutic effectiveness of rapamycin in sarcoidosis is first coined.

Keywords:

sarcoidosis, autoimmunity, triggers, vimentin, major histocompatibility complex, ASIA-syndrome

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References


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Published

2020-06-15

How to Cite

Starshinova , A., Churilov , L., Ershov, G., Zinchenko, Y., & Yablonskiy, P. (2020). Autoimmune aspects of pulmonary sarcoidosis*. Vestnik of Saint Petersburg University. Medicine, 14(4), 333–336. https://doi.org/10.21638/spbu11.2019.419

Issue

Vol. 14 No. 4 (2019)

Section

Internal medicine

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.

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