НЕГАТИВНЫЕ ЭФФЕКТЫ ТРАНСПЛАНТАЦИИ АУТОЛОГИЧНОЙ ЖИРОВОЙ ТКАНИ, ОБОГАЩЕННОЙ КУЛЬТУРОЙ СТВОЛОВЫХ КЛЕТОК (ОБЗОР ЛИТЕРАТУРЫ)

Николай Сергеевич Романенков; Константин Николаевич Мовчан

doi:10.21638/11701/spbu11.2017.403

Authors

Николай Сергеевич Романенков St. Petersburg Medical informational analytic center, 30, lit. A, ul. Shkapina, St. Petersburg, 198095, Russian Federation
Константин Николаевич Мовчан St. Petersburg Medical informational analytic center, 30, lit. A, ul. Shkapina, St. Petersburg, 198095, Russian Federation ; North-West State Medical University named after I. I. Mechnikov, 41, ul. Kirochnaya, St. Petersburg, 191015, Russian Federation

DOI:

https://doi.org/10.21638/11701/spbu11.2017.403

Abstract

The data here represents those of specialists in plastic, reconstructive and aesthetic surgery who investigated
the risks of development and structure of cell therapy-associated complications, both at the stage of collecting biological material for stem cells (SC) isolation and their subsequent transplantation.Data analysis suggests that even in minimally invasive surgical procedures during cell-associated lipotransfer (CAL), these surgeries are still fraught with risks of complications even in cases of somatically healthy patients for aesthetic indications. The incidence of life-threatening complications of CAL varies from 0.02% to 0.3%. It is clear that CAL-surgery must be carried out exclusively on the testimony based on the data of clinical examination of patients before SC transplantation. To prevent CAL complications in the postoperative period, the rules of aseptic and antiseptic, comprehensive thrombotic events prevention (irrespective of surgery), targeted compensatory adjustment of concomitant pathology of the patient must be scrupulously observed. Refs 70.

Keywords:

plastic surgery, surgery complications, mesenchymal stem cells, adipose tissue

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References

References

Flynn T., Coleman W. History of liposuction. Dermatol. Surg.,2000, no. 26, pp. 511–520.

Illouz Y. Body contouring by lipolysis: a 5-year experience with over 3000 cases. Plast. Reconstr. Surg.,1983, no. 72, pp. 591–597.

Frank S. J., Flusberg M., Friedman S., Swinburne N., Sternschein M., Wolf E. L., Stein M. W. CT appearance of common cosmetic and reconstructive surgical procedures and their complications. Clin. Radiol.,2013, no. 68, pp.72–78.

Stephan P. J., Kenkel J. M. Updates and advances in liposuction.Aesthet. Surg. J., 2010, no. 30,pp. 83–97.

Zuk P. A., Zhu M., Mizuno H., Huang J., Futrell J. W., Katz A. J., Benhaim P., Lorenz H. P., Hedrick M. H. Multilineage cells from human adipose tissue: implications for cell-based therapies.Tissue Eng.,

2001, vol. 7,no. 2, pp.211–226.

Yoshimura K., Sato K., Aoi N. et al. Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells.Aesthetic Plast. Surg., 2008, vol. 32, no. 1, pp. 48–55.

Castro-Govea Y., De La Garza-Pineda O., Lara-Arias J., Chacón-Martínez H., Mecott-Rivera G.,

Salazar-Lozano A., Valdes-Flores E. Cell-assisted lipotransfer for the treatment of Parry-Romberg syndrome.

Arch. Plast. Surg., 2012, vol. 39, no. 6, pp. 659–662.

Lee S. K., Kim D. W., Dhong E. S., Kurita M., Inoue K., Suga H., Eto H., Kato H., Hirohi T., Harii K.

Facial soft tissue augmentation using autologous fat mixed with stromal vascular fraction.Arch. Plast.Surg.,

2012, vol. 39, no. 5, pp. 534–539.

Yoshimura K., Sato K., Aoi N., et al. Cell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells. Dermatol. Surg., 2008, vol. 34, no. 9, pp. 1178–1185.

Yoshimura K., Asano Y., Aoi N., Kurita M., Oshima Y., Sato K., Inoue K., Suga H., Eto H., Kato H.,

Harii K. Progenitor-enriched adipose tissue transplantation as rescue for breast implant complications.

Breast J., 2010, no. 16, pp. 169–175

Zhou Y., Wang J., Li H., Liang X., Bae J., Huang X., Li Q. Efficacy and safety of cell-assisted lipotransfer: A systematic review and meta-analysis. Plast. Reconstr. Surg., 2016, vol. 137, no. 1, pp. 44–57.

Lehnhardt M., Homann H. H., Daigeler A., Hauser J., Palka P., Steinau H. U. Major and lethal complications of liposuction: a review of 72 cases in Germany between 1998 and 2002. Plast. Reconstr.

Surg.,2008, no. 121, pp. 396–403.

Kim Y. H., Cha S. M., Naidu S., Hwang W. J. Analysis of postoperative complications for superficial

liposuction: a review of 2398 cases. Plast. Reconstr. Surg., 2011, no. 127, pp. 863–871.

Stephan P. J., Kenkel J. M. Updates and advances in liposuction. Aesthet. Surg. J., 2010, no. 30,pp. 83–97.

Grazer F. M., de Jong R. H. Fatal outcomes from liposuction: census survey of cosmetic surgeons.Plast. Reconstr. Surg., 2000, no. 105, pp. 436–448.

Rao B. R., Fly S. F., Hoffman R. S. Deaths related to liposuction. The New England Journal of Medicine,1999, vol. 340, no. 19, pp. 1471–1475.

Vongpaisarnsin K., Tansrisawad N., Hoonwijit U., Jongsakul T. Pseudomonas aeruginosa septicemia causes death following liposuction with allogenic fat transfer and gluteal augmentation. Int. J. Legal Med.,2014. doi 10.1007/s00414-014-1056-3.

Ovrebo K. K., Grong K., Vindenes H. Small intestinal perforation and peritonitis after abdominal

suction lipoplasty. Ann. Plast. Surg., 1997, vol. 38, no. 6, pp. 642–644.

Talmor M., Hoffman L. A., Lieberman M. Intestinal perforation after suction lipoplasty: a case report and review of the literature. Ann. Plast. Surg., 1997, vol. 38, no. 2, pp. 169–172.

Mallappa M., Rangaswamy M., Badiuddin M. F. Small intestinal perforation and peritonitis after

liposuction. Aesth. Plast. Surg., 2007, no. 31, pp. 589–592.

Coronado-Malagón M., Tauffer-Carrion L. T. Jejunal perforation after abdominal liposuction, bilateral breast augmentation and facial fat grafting. Can. J. Plast. Surg., 2012, vol. 20, no. 3, pp. 197–198.

Sterodimas A., Boriani F., Magarakis E., Nicaretta B., Pereira L. H., Illouz Y. G. Thirtyfour years of

liposuction: past, present and future. Eur. Rev. Med. Pharmacol. Sci., 2012, no. 16, pp. 393–406.

Di Candia M., Charles M. Malata aesthetic and functional abdominal wall reconstruction after multiple bowel perforations secondary to liposuction. Aesth. Plast. Surg., 2011, no. 35, pp. 274–277.

Raman S. R., Pokala N., Cosgrove J., Jamil Z. Colocutaneous fistula after suction lipoplasty: case

report and literature review. Ann. Plast. Surg., 2010, vol. 64, no. 4, pp. 503–505.

Lim H., Kim H. J., Cho Y. S. Active bleeding in abdominal wall developing after liposuction. Emerg.Med. J., 2008, no. 25, p. 814.

Dixit V. V., Wagh M. S. Unfavourable outcomes of liposuction and their management. Indian J. Plast.Surg., 2013, no. 46, pp. 377–392.

You J., Chung Y., Baek S., Chung S. P., Kim M.-J. Imaging findings of liposuction with an emphasis on postsurgical complications. Korean J. Radiol., 2015, vol. 16, no. 6, pp. 1197–1206.

Beeson W. H., Slama T. G., Beeler R. T., Rachel J. D., Picerno N. A. Group A streptococcal fasciitis

after submental tumescent liposuction. Arch. Facial Plast. Surg., 2001, no. 3, pp. 277–279.

Heitmann C., Czermak C., Germann G. Rapidly fatal necrotizing fasciitis after aesthetic liposuction.Aesth. Plast. Surg., 2000, no. 24, pp. 344–347.

Giannella M., Pistella E., Perciaccante A., Venditti M. Soft tissue infection caused by Mycobacterium chelonae following a liposculpture and lipofilling procedure. Ann. Ital. Med. Int., 2005, no. 20,pp. 245–247.

Fisher E. J., Gloster H. M. Jr. Infection with Mycobacterium abscessus after Mohs micrographic surgery in an immunocompetent patient. Dermatol. Surg., 2005, vol. 31, no. 7, pp. 790–794.

Meyers H., Brown-Elliott B. A., Moore D., Curry J., Truong C., Zhang Y., Wallace Jr. R. J. An outbreak of Mycobacterium chelonae infection following liposuction. Clin. Infect. Dis., 2002, no. 34, pp. 1500–1507.

Murillo J., Torres J., Ríos-Fabra A., Irausquin E., Istúriz R., Guzmán M., Castro J., Rubino L., Cordido M. Skin and wound infection by rapidly growing mycobacteria: An unexpected complication of liposuction and liposculpture. Arch. Dermatol., 2000, no. 136, pp. 1347–1352.

Fayad L. M., Carrino J. A., Fishman E. K. Musculoskeletal infection: role of CT in the emergency

department. Radiographics, 2007, no. 27, pp. 1723–1736.

Shin S. U., Lee W., Park E. A., Shin C. I., Chung J. W., Park J. H. Comparison of characteristic CT

findings of lymphedema, cellulitis, and generalized edema in lower leg swelling. Int. J. Cardiovasc. Imaging,

2013, no. 29, pp. 135–143.

Chung Y. E., Kim Y. E., Park I., You J. S. Subcutaneous emphysema after carbon dioxide injection.

J. Emerg. Med., 2014, no. 47, pp. 89–90.

Heinze S., Puschel K., Tsokos M. Necrotizing fasciitis with fatal outcome: a report of two cases.

Forensic Sci. Med. Pathol., 2011, no. 7, pp. 278–282.

Sherman J. E., Fanzio P. M., White H., Leifer D. Blindness and necrotizing fasciitis after liposuction and fat transfer. Plast. Reconstr. Surg., 2010, vol. 126, no. 4, pp. 1358–1363.

Gonzáles A., Marin de la Cruz D., Palao Doménech R., Barret Nerin J. P. Necrotizing fasciitis after

liposuction. Acta Chir. Plast., 2007, vol. 49, no. 4, pp. 99–102.

Nagelvoort R. W., Hulstaert P. F., Kon M., Schuurman A. H. Necrotising fasciitis and myositis as serious complications after liposuction. Ned. Tijdschr. Geneeskd., 2002, vol. 146, no. 50, pp. 2430–2435.

Heitmann C., Czermak C., Germann G. Rapidly fatal necrotizing fasciitis after aesthetic liposuction.Aesthetic Plast. Surg., 2000, vol. 24, no. 5, pp. 344–347.

Umeda T., Ohara H., Hayashi O., Ueki M., Hata Y. Toxic shock syndrome after suction lipectomy.

Plast. Reconstr. Surg., 2000, vol. 106, no. 1, pp. 204–209.

Barillo D. J., Cancio L. C., Kim S. H., Shirani K. Z., Goodwin C. W. Fatal and near-fatal complications of liposuction. South Med. J., 1998, vol. 91, no. 5, pp. 487–492.

Gibbons M. D., Lim R. B., Carter P. L. Necrotizing fasciitis after tumescent liposuction. Am. Surg.,1998, vol. 64, no. 5, pp. 458–460.

Chaudhry A. A., Baker K. S., Gould E. S., Gupta R. Necrotizing fasciitis and its mimics: what radiologists need to know. Am. J. Roentgenol., 2015, no. 204, pp. 128–139.

Hakkarainen T. W., Kopari N. M., Pham T. N., Evans H. L. Necrotizing soft tissue infections: review and current concepts in treatment, systems of care, and outcomes. Curr. Probl. Surg., 2014, no. 51, pp. 344–362.

Geerts W. H., Heit J. A., Clagett G. P., Heit J. A., Samama C. M., Lassen M. R., Colwell C. W. Prevention of venous thromboembolism. Chest, 2001, vol. 119, no. 1, pp. 132–175.

Uemura K., Kikuchi Y., Shintani-Ishida K., Nakajima M., Yoshida K. A fatal case of post-operative pulmonary thromboembolism with cosmetic liposuction. J. Clin. Forensic Med., 2006, vol. 13, no. 1, pp. 41–43.

Esmon C. T. Basic mechanisms and pathogenesis of venous thrombosis. Blood Rev.,

2009, no. 23,pp. 225–229.

Gravante G., Araco A., Sorge R., Araco F., Nicoli F., Caruso R., Langiano N., Cervelli V. Pulmonary

embolism after combined abdominoplasty and flank liposuction: a correlation with the amount of fat removed.

Ann. Plast. Surg., 2008, vol. 60, no. 6, pp. 604–608.

Conkbayır C., Kenan S., Emiroğlu O. Massive pulmonary thromboembolism after abdominoplasty and liposuction. Arch. Turk. Soc. Cardiol., 2011, vol. 39, no. 5, pp. 410–413.

Jurgens W. J., Oedayrajsingh-Varma M. J., Helder M. N., Zandiehdoulabi B., Schouten T. E., Kuik D. J., Ritt M. J., van Milligen F. J. Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue:

implications for cell-based therapies. Cell Tissue Res., 2008, vol. 332, no. 3, pp. 415–426.

Schipper B. M., Marra K. G., Zhang W., Donnenberg A. D., Rubin J. P. Regional anatomic and age

effects on cell function of human adipose-derived stem cells. Ann. Plast. Surg., 2008, vol. 60, no. 5, pp. 538–544.

Lee H. C., An S. G., Lee H. W., Park J. S., Cha K. S., Hong T. J., Park J. H., Lee S. Y., Kim S. P., Kim Y. D., Chung S. W., Bae Y. C., Shin Y. B., Kim J. I., Jung J. S. Safety and effect of adipose tissue-derived stem cell implantation in patients with critical limb ischemia: a pilot study. Circ. J., 2012, no. 76, pp. 1750–1760.

Mojallal A. Influence of negative pressure when harvesting adipose tissue on cell yield of the stromal-vascular fraction. Biomed. Mater. Eng., 2008, vol.18, no. 4–5, pp. 193–197.

Matsumoto D. Influences of preservation at various temperatures on liposuction aspirates. Plast. Reconstr. Surg., 2007, vol. 120, no. 6, pp. 1510–1517.

Boquest A. C. Isolation of stromal stem cells from human adipose tissue. Methods Mol. Biol., 2006, no. 325, pp. 35–46.

Dubois S. G. Isolation of human adipose-derived stem cells from biopsies and liposuction specimens.Methods Mol. Biol., 2008, no. 449, pp. 69–79.

Aronowitz J. A., Ellenhorn J. D. Adipose stromal vascular fraction isolation: a head-to-head comparison of four commercial cell separation systems. Plast. Reconstr. Surg., 2013, vol. 132, no. 6, pp. 932–939

Kirkpatrick C. J. Comparative effects of trypsin, collagenase and mechanical harvesting on cell membrane lipids studied in monolayer-cultured endothelial cells and a green monkey kidney cell line. Biochim.Biophys. Acta., 1985, vol. 846, no. 1, pp. 120–126.

Pilgaard L. Comparative analysis of highly defined proteases for the isolation of adipose tissue-derived stem cells. Regen. Med., 2008. vol. 3, no. 5, pp. 705–715.

Domenis R. Adipose tissue derived stem cells: in vitro and in vivo analysis of a standard and three commercially available cell-assisted lipotransfer techniques. Stem Cell Res. Ther., 2015. vol. 6, no. 1, p. 2.

Yu N. Z., Huang J. Z., Zhang H., Wang Y., Wang X.-J., Zhao R., Bai M., Long X. A Systemic Review

of Autologous fat grafting survival rate and related severe complications. Chin. Med. J., 2015, vol. 128, no. 9,pp. 1245–1251.

Teimourian B. Blindness following fat injection. Plast. Reconstr. Surg., 1988, no. 82, p. 361.

Dreizen N. G., Framm L. Sudden unilateral visual loss after autologous fat injection into the glabellar area. Am. J. Ophthalmol.,1989, no. 107, pp. 85–87.

Egido J. A., Arroyo R., Marcos A., Jiménez-Alfaro I. Middle cerebral artery embolism and unilateral visual loss after autologous fat injection into the glabellar area. Stroke, 1993, no. 24, pp. 615–616.

Lee D. H., Yang H. N., Kim J. C., Shyn K. H. Sudden unilateral visual loss and brain infraction after

autologous fat injection into the nasolabial groove. Br. J. Ophthalmol.,1996, no. 80, pp. 1026–1027.

Feinendegen D. L., Baumgartner R. W., Schroth G., Mattle H. P., Tschopp H. Middle cerebral artery occlusion and ocular fat embolism after autologous fat injection in the face. J. Neurol., 1998, no. 245,pp. 53–54.

Danesh-Mayer H. V., Savino P. J., Sergott R. C. Case reports and small case series: ocular and cerebral ischemia following facial injection of autologous fat. Arch. Ophthalmol., 2001, no. 19, pp. 777–778.

Mineda K., Kuno S., Kato H., Kinoshita K., Doi K., Hashimoto I., Nakanishi H., Yoshimura K.

Chronic inflammation and progressive calcification as a result of fat necrosis: the worst outcome in fat grafting.

Plast. Reconstr. Surg., 2014, no. 133, pp. 1064–1072.