Conventional brain magnetic resonance imaging data as an indicator to perform HIV testing

Authors

  • Александр Андреевич Дроздов St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Владимир Максимович Черемисин St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; St. Petersburg Mariinsky Hospital, 56, Liteyniy pr., St. Petersburg, 191014, Russian Federation
  • Ирина Григорьевна Камышанская St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; St. Petersburg Mariinsky Hospital, 56, Liteyniy pr., St. Petersburg, 191014, Russian Federation
  • Алексей Авенирович Яковлев St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation;Clinical Infectious Disease Hospital named after S. P. Botkin no. 30, 3, ul. Mirgorodskaya, St. Petersburg, 191024, Russian Federation
  • Владимир Борисович Мусатов St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation;Clinical Infectious Disease Hospital named after S. P. Botkin no. 30, 3, ul. Mirgorodskaya, St. Petersburg, 191024, Russian Federation
  • Иван Павлович Федуняк North-Western State Medical University named after I. I. Mechnikov, 47, Piskarevsky pr., St. Petersburg, 195067, Russian Federation ; Clinical Infectious Disease Hospital named after S. P. Botkin no. 30, 3, ul. Mirgorodskaya, St. Petersburg, 191024, Russian Federation
  • Оксана Ивановна Федуняк Clinical Infectious Disease Hospital named after S. P. Botkin no. 30, 3, ul. Mirgorodskaya, St. Petersburg, 191024, Russian Federation
  • Мария Николаевна Артемьева Clinical Infectious Disease Hospital named after S. P. Botkin no. 30, 3, ul. Mirgorodskaya, St. Petersburg, 191024, Russian Federation

DOI:

https://doi.org/10.21638/11701/spbu11.2018.202

Abstract

HIV/AIDS is now a global pandemic and our region, “Eastern Europe and Central Asia” is World leading area in terms of the rate of HIV spread with the fraction of a newly infected person during the year 2016 of 11.87 %. In our practice, it has been noticed that at least 25 % of patients undergoing brain MRI have self-administered the study based on a personal feeling of “something wrong”. Many of them subjectively believe in MRI as in powerful method that allows detecting most significant pathologies. Consequently, that is MRI conclusion that guides patients for further consultations and testing. The purpose of this study was to evaluate the ability of conventional brain MRI data to serve as an indicator for HIV-testing in cases when AIDS-defining and highly HIV specific changes are not present. We composed a list of potentially significant criteria, composed test, and control groups, determined statistically significant criteria, assigned the numerical score to significant criteria, established MR-scoring system. Conventional brain MRI was shown to serve as a useful indicator for HIV testing when there is no clear evidence of AIDS-defining findings. MR-scoring system proposed in this study allows forming groups of patients with increased risk for HIV for subsequent HIVtesting.

Keywords:

MRI, HIV, AIDS, brain, screening

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References


References

AIDS by the numbers — 2016. UNAIDS.2016. Available at: http://www.unaids.org/en/resources/documents/2016/AIDS-by-the-numbers (accessed: 20.05.2017).

Fact Sheet 2016. UNAIDS.2016. Available at: http://www.unaids.org/sites/default/files/media_asset/UNAIDS_FactSheet_en.pdf (accessed: 20.05.2017).11-2-2018.indd 149 22.05.2018 19:42:09

Spravka: VICh-infektsiia v Rossiiskoi Federatsii na 31 dekabria 2014 g. [HIV infection in Russian Federtion as for December 31 2014]. Available at: http://www.hivrussia.ru/files/spravkaHIV2014.pdf (accessed:20.05.2017) (In Russian)

González-Scarano F., Martín-García J. The neuropathogenesis of AIDS. Nature Reviews Immunology,2005, vol. 5, no. 1, pp. 69–81.

Bowen L. N., Smith B., Reich D., Quezado M., Nath A. HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment. Nature Reviews Neurology, 2016, vol. 12, no. 11, pp. 662–674.

Modi M., Mochan A., Modi G. Management of HIV-associated focal brain lesions in developing countries.QJM: An International Journal of Medicine, 2004, vol. 97, no. 7, pp. 413–421.

Ragin A. B., Du H., Ochs R., Wu Y., Sammet C. L., Shoukry A., Epstein L. G. Structural brain alterations can be detected early in HIV infection. Neurology, 2012, vol. 79, no. 24, pp. 2328–2334.

Chiang M. C., Dutton R. A., Hayashi K. M., Lopez O. L., Aizenstein H. J., Toga A. W., Becker J. T.,Thompson P. M. 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry.Neuroimage, 2007, vol. 34, no. 1, pp. 44–60.

Ances B. M., Ortega M., Vaida F., Heaps J. R. P. Independent effects of HIV, aging, and HAART on brain volumetric measures. The Journal of Acquired Immune Deficiency Syndromes, 2012, vol. 59, no. 5, pp. 469–477.

McMurtray A., Nakamoto B., Shikuma C., Valcour V. Cortical atrophy and white matter hyperintensities in HIV: the Hawaii Aging with HIV Cohort Study. Journal of Stroke and Cerebrovascular Diseases,2012, vol. 59, no. 5, pp. 469–477.

Su T., Wit F. W., Caan M. W., Schouten J., Prins M., Geurtsen G. J., Cole J. H., Sharp D. J., Richard E.,Reneman L., Portegies P., Reiss P., Majoie C. B. White matter hyperintensities in relation to cognition in HIV-infected men with sustained suppressed viral load on combination antiretroviral therapy.AIDS, 2016, vol. 30, no. 15, pp. 2329–2339.

Lamprecht J., Wiedbrauck C. Sinusitis and other typical ENT diseases within the scope of acquired immunologic deficiency syndrome (AIDS). HNO, 1988, vol. 36, no. 12, pp. 489–492.

Del Borgo C., Del Forno A., Ottaviani F., Fantoni M. Sinusitis in HIV-infected patients. Journal of Chemotherapy, 1997, vol. 9, no. 2, pp. 83–88.

Ragin A. B., Wu Y., Storey P., Cohen B. A., Edelman R. R., Epstein L. G., Gartner S. Bone marrow diffusion measures correlate with dementia severity in HIV patients. American Journal of Neuroradiology, 2006, vol. 27, no. 3, pp. 589–592.

Gill P. S., Arora D. R., Arora B., Gill M., Gautam V., Karan J., Chaudhary U., Garg N. Lymphadenopathy — an important guiding tool for detecting hidden HIV-positive cases: a 6-year study. Journal of the International Association of Providers of AIDS Care, 2007, vol. 6, no. 4, pp. 269–272.

Levashkina I. M., Serebryakova S. V., Efimtsev A. Yu. Diffuzionno-tenzornaia MRT — sovremennyi metod otsenki mikrostrukturnykh izmenenii veshchestva golovnogo mozga (obzor literatury) [Diffusion-tensor MRI — the most up-to-date method to research microstructual changes in white matter (publications’review)]. Vestnik SPbSU. Series 11. Medicine, 2016, issue 4, pp. 39–54. (In Russian)

Magonov E. P. Kompleksnaia magnitno-rezonansnaia morfometriia ochagovykh i atroficheskikh izmenenii golovnogo mozga (na primere rasseiannogo skleroza i rannikh stadii VICh-infektsii). Аuthtoref. dis. …kand. med. nauk [Complex magnetic-resonance morphometry of focal and atrophic brain changes (with multypl sclerosis and early HIV-infection as an example). Thesis of PhD]. St. Petersbur, 2015. (In Russian)

AIDS by the numbers — 2016. UNAIDS.2016. Available at: http://www.unaids.org/en/resources/documents/2016/AIDS-by-the-numbers (accessed: 20.05.2017).

UNAIDS Report on the Global AIDS Epidemic, 2012. Joint United Nations Programme on HIV/AIDS and World Health Organization. UNAIDS.2012. Available at:http://www.unaids.org/sites/default/files/media_asset/20121120_UNAIDS_Global_Report_2012_with_annexes_en_1.pdf (accessed: 20.05.2017).

Fact Sheet 2016. UNAIDS.2016. Available at: http://www.unaids.org/sites/default/files/media_asset/UNAIDS_FactSheet_en.pdf (accessed: 20.05.2017).

Published

2018-06-29

How to Cite

Дроздов, А. А., Черемисин, В. М., Камышанская, И. Г., Яковлев, А. А., Мусатов, В. Б., Федуняк, И. П., … Артемьева, М. Н. (2018). Conventional brain magnetic resonance imaging data as an indicator to perform HIV testing. Vestnik of Saint Petersburg University. Medicine, 13(2), 136–151. https://doi.org/10.21638/11701/spbu11.2018.202

Issue

Section

Internal medicine

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