The effect of orexin-A on the morphofunctional characteristics of LPS-stimulated microglial cells

Авторы

DOI:

https://doi.org/10.21638/spbu11.2019.411

Аннотация

Microglial cells have a protective function and are essentially immunocytes present in the central nervous system. Activation of microglia results in the production of cytokines and trophic factors that can have a damaging or protective effect on brain cells. Orexin-A has anti-inflammatory and neuroprotective properties. Subcutaneous administration of orexin-A enhances the survival of mice with lipopolysaccharide-induced endotoxin shock, reducing the level of pro-inflammatory cytokines and chemokines. The aim of this study was to determine the effect of orexin-A administered intraventricularly on the morphological characteristics of microglial cells activated by intraperitoneal injection of lipopolysaccharide (LPS). With the introduction of lLPS, there is a change in the number of microglial cells in the somatosensory cortex, as well as in their morphology. When these indicators were analyzed after administration of orexin-A to animals against the background of LPS stimulation, no changes were detected.

Ключевые слова:

microglia, orexin-A, microglial cells processuses

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References

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Загрузки

Опубликован

15.06.2020

Как цитировать

Рунде, А. (2020). The effect of orexin-A on the morphofunctional characteristics of LPS-stimulated microglial cells. Вестник Санкт-Петербургского университета. Медицина, 14(4), 302– 306. https://doi.org/10.21638/spbu11.2019.411

Выпуск

Том 14 № 4 (2019)

Раздел

Неврология. Нейрохирургия. Психиатрия

Лицензия

Статьи журнала «Вестник Санкт-Петербургского университета. Медицина» находятся в открытом доступе и распространяются в соответствии с условиями Лицензионного Договора с Санкт-Петербургским государственным университетом, который бесплатно предоставляет авторам неограниченное распространение и самостоятельное архивирование.