The clinical and immunological features of bronchial asthma in patients with autoimmune thyroiditis

Авторы

  • Элла Чурюкина ФГБОУ ВО РостГМУ МЗ РФ, г.Ростов-на-Дону
  • Наталия Колесникова Rostov State Medical University, 29, Nakhichevanskii per., Rostov-on-Don, 344022, Russian Federation ; Kuban State Medical University, 4, ul. Sedina, Krasnodar, 350063, Russian Federation
  • Евгений Филиппов Rostov State Medical University, 29, Nakhichevanskii per., Rostov-on-Don, 344022, Russian Federation ; Kuban State Medical University, 4, ul. Sedina, Krasnodar, 350063, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.425

Аннотация

Bronchial asthma often can be combined with autoimmune thyroiditis, and both diseases are linked with the immune system dysfunction, although via different pathogenetic mechanisms, but intermingled. In this study the clinical course of bronchial asthma, respiratory function, immune and hormonal status in patients with bronchial asthma and autoimmune thyroiditis were compared to those in patients with pure bronchial asthma without thyroid disease. Along with the marked changes in cellular and humoral components of the immune system, clinical observations showed that the addition of autoimmune thyroiditis to bronchial asthma worsens asthma course: it leads to an increase in the frequency of exacerbations, shortening the duration of remission, a significant decrease in the flow rates of МEF50 and МEF75 compared with isolated bronchial asthma, probably, related to myxoedematous component of bronchial conductivity impairment.

Ключевые слова:

bronchial asthma, autoimmune thyroiditis, immune status, cytokines

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Библиографические ссылки


References

Fedoseev G.B. Bronchial asthma, G.B.Fedoseyev, V.I.Trofimov (Eds). St. Petersburg, Nordmedizdat Publ., 2006. (In Russian)

Fadeev V.V., Mel’nichenko G.A., Gerasimov G.A. Autoimmune thyroiditis. First pace to consensus. Problems of Endocrinology, 2001, no. 4, pp. 7–13. (In Russian)

Ginsberg J. Diagnosis and management of Graves’ Disease. Canadian Medical Association Journal, 2003, vol. 5, no. 168, pp. 575–585.

Churyukina E.V., Goloshubova E.A. Optimization of spirometric verification algorithm for bronchial asthma diagnosis. Russian Journal of Immunology, 2015, vol. 5, no. 9, p. 240. (In Russian)

Manzolli S., Macedo-Soares M.F., Vianna E.O., Sannomiya P. Allergic airway inflammation in hypothyroid rats. Journal Allergy & Clinical Immunology, 1999, vol. 3, no. 104, pp. 595–600.

Загрузки

Опубликован

15.06.2020

Как цитировать

Чурюкина, Э., Колесникова, Н. ., & Филиппов, Е. (2020). The clinical and immunological features of bronchial asthma in patients with autoimmune thyroiditis. Вестник Санкт-Петербургского университета. Медицина, 14(4), 353–356. https://doi.org/10.21638/spbu11.2019.425

Выпуск

Том 14 № 4 (2019)

Раздел

Внутренние болезни

Лицензия

Статьи журнала «Вестник Санкт-Петербургского университета. Медицина» находятся в открытом доступе и распространяются в соответствии с условиями Лицензионного Договора с Санкт-Петербургским государственным университетом, который бесплатно предоставляет авторам неограниченное распространение и самостоятельное архивирование.