The clinical and immunological features of bronchial asthma in patients with autoimmune thyroiditis

Authors

  • Ella Churyukina Rostov State Medical University, 29, Nakhichevanskii per., Rostov-on-Don, 344022, Russian Federation ; Kuban State Medical University, 4, ul. Sedina, Krasnodar, 350063, Russian Federation
  • Natalia Kolesnikova Rostov State Medical University, 29, Nakhichevanskii per., Rostov-on-Don, 344022, Russian Federation ; Kuban State Medical University, 4, ul. Sedina, Krasnodar, 350063, Russian Federation
  • Evgeny Filippov Rostov State Medical University, 29, Nakhichevanskii per., Rostov-on-Don, 344022, Russian Federation ; Kuban State Medical University, 4, ul. Sedina, Krasnodar, 350063, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.425

Abstract

Bronchial asthma often can be combined with autoimmune thyroiditis, and both diseases are linked with the immune system dysfunction, although via different pathogenetic mechanisms, but intermingled. In this study the clinical course of bronchial asthma, respiratory function, immune and hormonal status in patients with bronchial asthma and autoimmune thyroiditis were compared to those in patients with pure bronchial asthma without thyroid disease. Along with the marked changes in cellular and humoral components of the immune system, clinical observations showed that the addition of autoimmune thyroiditis to bronchial asthma worsens asthma course: it leads to an increase in the frequency of exacerbations, shortening the duration of remission, a significant decrease in the flow rates of МEF50 and МEF75 compared with isolated bronchial asthma, probably, related to myxoedematous component of bronchial conductivity impairment.

Keywords:

bronchial asthma, autoimmune thyroiditis, immune status, cytokines

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References


References

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Fadeev V.V., Mel’nichenko G.A., Gerasimov G.A. Autoimmune thyroiditis. First pace to consensus. Problems of Endocrinology, 2001, no. 4, pp. 7–13. (In Russian)

Ginsberg J. Diagnosis and management of Graves’ Disease. Canadian Medical Association Journal, 2003, vol. 5, no. 168, pp. 575–585.

Churyukina E.V., Goloshubova E.A. Optimization of spirometric verification algorithm for bronchial asthma diagnosis. Russian Journal of Immunology, 2015, vol. 5, no. 9, p. 240. (In Russian)

Manzolli S., Macedo-Soares M.F., Vianna E.O., Sannomiya P. Allergic airway inflammation in hypothyroid rats. Journal Allergy & Clinical Immunology, 1999, vol. 3, no. 104, pp. 595–600.

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Published

2020-06-15

How to Cite

Churyukina , E., Kolesnikova, N. ., & Filippov, E. (2020). The clinical and immunological features of bronchial asthma in patients with autoimmune thyroiditis. Vestnik of Saint Petersburg University. Medicine, 14(4), 353–356. https://doi.org/10.21638/spbu11.2019.425

Issue

Vol. 14 No. 4 (2019)

Section

Internal medicine

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.