Immune system as a part of regulatory and integrating apparatus of the body: A biomedical philosopheme*

Authors

  • Andrey Vasiliev St. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation
  • Leonid Сhurilov St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ;St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation
  • Tamar Fedotkina St. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation;Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 44, Thoreza pr., St. Petersburg, 194223, Russian Federation
  • Alexander Trashkov Petersburg Nuclear Physics Institute named after B.P.Konstantinov of National Research Centre “Kurchatov Institute”, 1, mkr. Orlova roshcha, Leningradskaya oblast, Gatchina, 188300, Russian Federation ; Peter the Great St. Petersburg Polytechnic University, 29, Polytechnicheskaya ul., St. Petersburg, 195251, Russian Federation
  • Alia Stanova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0002-9268-2058
  • Vladimir Utekhin 1 St. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation ; St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.403

Abstract

This conceptual article addresses different underrecognized aspects of the immune system physiological activities. These ones include: the role of the immune system and physiologic autoimmunity in maintaining normal body’s own cell populations; its involvement in placentation and mother-to-fetus interactions; its embedding into immune-neuroendocrine communicative and integrating apparatus designated first of all for support of unique multicellularity of the organism and for regulation of its somatic cells’ growth and life. Besides cytokines, a powerful instrument of somatic regulation is agonistic (functional) autoantibodies, able to act on their receptors in hormone-like manner. The regulatory potential of antiidiotypic immunity is underappreciated. There is evidence, that anti-idiotypic antibodies can create internal immunological images and copy the ligand properties of different bioregulators and even drugs. What makes the regulatory interactions even more complex is the fact that antibodies are capable of penetrating living cell membrane, permeating the nucleus and produce a wide spectrum of regulatory effects on transcription, translation and post-transcription modifications.

Keywords:

agonistic autoantibodies, functional autoantibodies, idiotype-antiidiotypic network, immunoglobulin-mediated regulation, antinuclear antibodies, physiologic autoimmunity, anti-receptor antibodies, gene expression, immune homunculus (immunculus)

Downloads

Download data is not yet available.
 

References


References

Vasiliev A.G., Churilov L.P., Trashkov A.P., Utekhin V.J. Evolution of the immune system and regulatory effects of antibodies. Tsitologiya, 2018, no. 60 (2), pp. 71–80. (In Russian)

Zaichik A. Sh., Churilov L.P. Autoimmunity as a system of physiologic regulation of morphofunctional processes. Clin. Pathophysiol., 2002, no. 12 (2), pp. 8–17. (In Russian)

Zaichik A. Sh., Churilov L.P., Utekhin V.J. Autoimmune regulation of genetically determined cell functions in health and disease. Pathophysiology, 2008, vol. 15, no. 3, pp. 191–207.

Blalock J.E. The immune system as a sensory organ. J.Immunol., 1984, vol. 132, no. 3, pp. 1067–1070.

Zaichik A.M., Poletaev A.B., Churilov L.P. Identification of “self ” and interaction with “self ” as a basic form of adaptive immune system activity. Proceeding 1. Vestnik Sankt-Petersburgskogo Universiteta. Series 11. Meditsina, 2013, no. 1, pp. 7–16. (In Russian)

Cohen I.R., Young D.B. Autoimmunity, microbial immunity and the immunological homunculus.Immunology today 1991, vol. 12, no. 4, pp. 105–110.

Cabral-Marques O., Riemekasten G. Functional autoantibodies targeting G protein-coupled receptors in rheumatic diseases. Nat. Rev. Rheumatol., 2017, vol. 13, no. 11, pp. 648–656.

Ruiz-Argüelles A., Rivadeneyra-Espinoza L., Alarcon-Segovia D. Antibody penetration into living cells: pathogenic, preventive and immuno-therapeutic implications. Curr. Pharm. Des., 2003, vol. 9,no. 23, pp. 1881–1887.

Jerne N.K. Idiotypic networks and other preconceived ideas. Immunol. Rev., 1984, vol. 79, no. 1, pp. 5–24.

Farid-Nadir R., Linticum D. S. Anti-idiotypes, receptors and molecular mimicry. New York, Springer Verlag, 1988. 317 p.

Downloads

Published

2020-06-15

How to Cite

Vasiliev , A. ., Сhurilov L., Fedotkina , T., Trashkov , A. ., Stanova , A., & Utekhin, V. . (2020). Immune system as a part of regulatory and integrating apparatus of the body: A biomedical philosopheme*. Vestnik of Saint Petersburg University. Medicine, 14(4), 273–276. https://doi.org/10.21638/spbu11.2019.403

Issue

Vol. 14 No. 4 (2019)

Section

Pathological physiology

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.

Most read articles by the same author(s)