Autoimmune markers in prognosis of Assisted Reproductive Technology efficiency
DOI:
https://doi.org/10.21638/spbu11.2022.401Abstract
According to reports, the efficiency of IVF/ICSI protocols is decreased in antithyroid antibodypositive patients as opposed to antibody negatives. However, there are opposite data indicating the absence of the antibody’s impact on the outcome of infertility treatment with assisted reproductive technologies. The prospective study enrolled 90 patients with infertility undergoing treatment with assisted reproductive technologies. The follicular fluid obtained on the day of oocyte retrieval was evaluated for antithyroid peroxidase and antithyroglobulin antibodies using commercial ELISA kits. The main group (n = 45) included women with verified autoimmune thyroiditis and measurable serum and follicular fluid levels of antithyroid antibodies. The comparison group was represented by 45 women without autoimmune thyroiditis. A reliably lower ovarian reserve parameters was noted in the study group relatively to the comparison group. It has been established that follicular fluid AT-TPO levels are negatively associated with the number of two-pronuclear zygotes. Moreover, the serum levels of AT-TPO ≥ 305,0 IU/ml are reliably associated with a higher frequency of suboptimal response to COS and lower clinical pregnancy rate in IVF (IVF/ICSI) cycles.
Keywords:
antibodies, AT-TPO, IVF/ICSI, suboptimal response, embryos, clinical pregnancy
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Литература
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Vissenberg R., Manders U. D., Mastenbroek S., Fliers E., Afink G. B., Ris-Stalpers C., Goddijn M., Bisschop P. H. Pathophysiological aspects of thyroid hormone disorder/thyroid peroxidase autoantibodies and reproduction // Hum. Reprod. Update. 2015. Vol. 21, no. 3. P. 378- 387.
Cline A., Kutteh W.Is there a role of autoimmunity in implantation failure after in-vitro fertilization?// Curr. Opin. Obstet. Gynecol. 2009. Vol. 21. P. 291–295.
Monteleone P., Parrini D., Faviana P., Carletti E., Casarosa E., Uccelli A., Cela V., Genazzani A. R.,Artini P. G.Female infertility related to thyroid autoimmunity: the ovarian follicle hypothesis // Am. J. Reprod. Immunol. 2011. Vol. 66, no. 2. P. 108–114.
Weghofer A., Himaya E., Kushnir V. A., Barad D. H., Gleicher N. The impact of thyroid function and thyroid autoimmunity on embryo quality in women with low functional ovarian reserve: a casecontrol study // Reprod. Biol. Endocrinol. 2015. Vol. 13, no. 1. P. 43–49.
Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting // Hum. Reprod. 2011. Vol. 26, no. 6. P. 1270–1283.
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Gardner D. K., Sakkas D. Assessment of embryo viability: the ability to select a single embryo for transfer — a review // Placenta. 2003. Vol. 24. P. 5–12.
Farquhar C., Marjoribanks J. Assisted reproductive technology: an overview of Cochrane Reviews // Cochrane Database Syst. Rev. 2018. Vol. 8, no. 8. P. CD010537
Zhong Y., Ying Y., Wu H., Zhou C., Xu Y., Wang Q., Li J., Shen X., Li J.Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer // Int. J. Med. Sci. 2012. Vol. 9. P. 121–125.
Medenica S., Garalejia E., Arsic B., Medjo B., Bojovic Jovic D., Abazovic D., Vukovic R., Zarkovic M.Follicular fluid thyroid autoantibodies, thyrotropin, free thyroxine levels and assisted reproductive technology outcome // PLoS ONE. 2018. Vol. 13, no. 10. P. e0206652.
Miko E., Meggyes M., Doba K., Farkas N., Bogar B., Barakonyi A., Szereday L., Szekeres-Bartho J., Mezosi E. Characteristics of peripheral blood NK and NKT-like cells in euthyroid and hypothyroid women with autoimmunity, experiencing reproductive failure // J. Reprod. Immunol. 2017. Vol. 124. P. 62–70.
Sokolov D. I., Mikhailova V. A., Agnayeva A. O., Bazhenov D. O., Khokhlova E. V., Bespalova O. N., Gzgzyan A. M., Selkov S. A. NK and trophoblast cells interaction: cytotoxic activity on recurrent pregnancy loss // Gynecol. Endocrinol. 2019. Vol. 35, no. 1. P. 5–10.
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Published
2023-05-31
How to Cite
Safarian, G. ., Dzhemlikhanova, L. ., Kogan, I. ., Niauri, D. ., Bespalova , O. ., & Gzgzyan, A. (2023). Autoimmune markers in prognosis of Assisted Reproductive Technology efficiency. Vestnik of Saint Petersburg University. Medicine, 17(4), 238–253. https://doi.org/10.21638/spbu11.2022.401
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Obstetrics and ginecology
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Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.
