Осложнения после вакцинации препаратами против SARS-СoV-2: обзор зарубежной литературы

Авторы

  • Елена Проскурнина Медико-генетический научный центр им. академика Н. П. Бочкова, Российская Федерация, 115522, Москва, ул. Москворечье, 1
  • Денис Иванов Институт биомедицинских исследований — филиал Федерального научного центра «Владикав- казский научный центр Российской академии наук», Российская Федерация, 362025, Владикавказ, ул. Пушкинская, 47
  • Александр Редько Санкт-Петербургская профессиональная ассоциация медицинских работников, Российская Федерация, 194354, Санкт-Петербург, Северный пр., 1

DOI:

https://doi.org/10.21638/spbu11.2023.202

Аннотация

Острая респираторная инфекция, вызываемая коронавирусом SARS-CoV-2, явилась причиной объявленной в марте 2020 г. пандемии. Для профилактики этого заболевания были разработаны и внедрены в массовое применение различные вакцины, в том числе на инновационной генной платформе. Цель обзора — провести анализ зару- бежной литературы, посвященной поствакцинальным осложнениям при использо- вании зарубежных вакцин, а также цельновирионных вакцин за период c 2021 г. по январь 2023 г. Источники, используемые в публикации, были получены из базы данных Medline, а также анализировались статьи в рецензируемых журналах и официальные отчеты. Поствакцинальные осложнения связаны со специфическим повреждением органов или систем либо самой вакциной напрямую, либо опосредованно в результате обострения хронического процесса. Патогенез поствакцинальных осложнений зависит от состава вакцины. Все осложнения сгруппированы по органам и системам. Вакцины, содержащие антигены SARS-CoV-2, могут активировать аутоиммунные реакции за счет гомологии, а также активации существующих реакций у предрасположенных пациентов, что подтверждается эффективностью иммуносупрессивной терапии. Инновационные платформы, использующие генные технологии, являются настолько сложными и глубинно действующими, что могут быть внедрены в широкую медицинскую практику только после тщательнейшего и всестороннего изучения эффектов и механизмов. Научные достижения должны следовать этическим принципам врачевания, и прежде всего primum non nocere. Специалисты во всем мире подчеркивают необходимость продолжающихся наблюдений за состоянием людей с целью защиты их здоровья и оценки долгосрочной безопасности препаратов.

Ключевые слова:

ARS-CoV-2, COVID-19, вакцинация, осложнения, обзор

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Загрузки

Опубликован

29.09.2023

Как цитировать

Проскурнина, . Е. ., Иванов, . Д. ., & Редько, . А. (2023). Осложнения после вакцинации препаратами против SARS-СoV-2: обзор зарубежной литературы. Вестник Санкт-Петербургского университета. Медицина, 18(2), 112–140. https://doi.org/10.21638/spbu11.2023.202

Выпуск

Том 18 № 2 (2023)

Раздел

Внутренние болезни

Лицензия

Статьи журнала «Вестник Санкт-Петербургского университета. Медицина» находятся в открытом доступе и распространяются в соответствии с условиями Лицензионного Договора с Санкт-Петербургским государственным университетом, который бесплатно предоставляет авторам неограниченное распространение и самостоятельное архивирование.