NK-cells in placenta of female patients with type 1 diabetes mellitus

Anna   Drobintseva; Dmitriy Medvedev; Irina Yushkova; Victoria Polyakova

doi:10.21638/spbu11.2019.429

Authors

Anna Drobintseva St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation ; St. Petersburg Medico-Social Institute, 72, Kondrat’evskii pr., St. Petersburg, 195271, Russian Federation
Dmitriy Medvedev St. Petersburg Medico-Social Institute, 72, Kondrat’evskii pr., St. Petersburg, 195271, Russian Federation ; St. Petersburg Institute of Bioregulation and Gerontology, 3, pr. Dinamo, St. Petersburg, 197110, Russian Federation
Irina Yushkova St. Petersburg Medico-Social Institute, 72, Kondrat’evskii pr., St. Petersburg, 195271, Russian Federation
Victoria Polyakova St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation ; St. Petersburg Medico-Social Institute, 72, Kondrat’evskii pr., St. Petersburg, 195271, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.429

Abstract

Placenta is a temporary organ that performs multiple functions to provide a normal course of the intrauterine development of the child. However, immune interactions in placenta are not well understood. Since women with type 1 diabetes mellitus have a greater risk of adverse pregnancy outcomes due to aberrant immunological adaptation, the study of immunological interactions in placenta of these women is of particular interest. In this study a comparative analysis of the age-related expression parameters of marker of NK-cells (CD57) in placenta in patients with type 1 diabetes mellitus was performed. The current study revealed differences in the expression parameters of NK-cells marker between two age subgroups of the patients and compared to healthy controls. The results indicate the high significance of inflammatory type 1 diabetes mellitusmarkers in women with type 1 diabetes mellitus for assessing the course of pregnancy and the possible development of somatic pathology in newborns, especially from older women.

Keywords:

type 1 diabetes mellitus, T1DM, pregnancy, NK-cells, autoimmunity in pregnancy

Downloads

Download data is not yet available.

References

References

Feldman A.Z., Brown F.M. Management of type 1 diabetes in pregnancy. Curr. Diab. Rep., 2016,vol. 16, no. 76. https://doi.org/10.1007/s11892-016-0765-z.

Mor G., Cardenas I. The immune system in pregnancy: a unique complexity. Am. J. Reprod. Immunol., 2010, vol. 63, no. 6, pp. 425–433. https://doi.org/10.1111/j.1600-0897.2010.00836.x

Tabarkiewicz J., Selvan S.R., Cools N.J. Autoimmunity in reproductive health and pregnancy. Immunol. Res., 2018. 9501865.

Groen B., van der Wijk A.E., van den Berg P.P., Lefrandt J.D., van den Berg G., Sollie K.M., de Vos P.,Links T.P., Faas M.M. Immunological adaptations to pregnancy in women with type 1 diabetes. Sci. Rep., 2015, Sep 22; 5: 13618. https://doi.org/10.1038/srep13618.

Aylamazyan E.K. Obstetrics. Textbook for Medical Universities. St. Petersburg, SpezLit Publ., 2003. (In Russian)

Ailamazyan E.K., Polyakova V.O., Linkova N. S., Kvetnoy I.M., Durnova A.O. The role of resident immune cells in the development of the placenta is normal and in pathology. Zhurnal akusherstva i zhenskikh boleznei, 2010, vol. 59, no. 6, pp. 8–14. (In Russian)