Clinical experience of dispensary observation for ten thousand patients with Hashimoto’s autoimmune thyroiditis: Some features of aetiology, manifestations, treatment and comorbidity*

Yuri  Stroev

doi:10.21638/spbu11.2019.422

Authors

Yuri Stroev St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.422

Abstract

Chronic autoimmune thyroiditis is the most common autoimmune disease and the main cause of hypothyroidism in the world. From March 14, 2011 to present we have systematically monitored in our outpatient dispensary center over 10,000 persons aged 1 year to 87 years with a newly diagnosed autoimmune thyroiditis (having totally ≈19,500 of their dynamic observations). In this article we address some features of autoimmune thyroiditis, namely aetiology (possible genetic predisposition and the role of some triggers, including excessive iodine intake), early manifestations of hypothyroidism, comorbidity (such as stigmata of non-syndromal marfanoid phenotype, metabolic syndrome, pituitary prolactinomas, lymphomas and some other malignancies) and treatment strategy (the proper time to start therapy, adjustment of the doses of Levothyroxine, monitoring follow-up dinamics of the disease and possible
complications of the therapy). Hashimoto’s thyroiditis in our experience looks like important cause of hyperprolactinemia and female/male infertility and essential prerequisite of early adolescent metabolic syndrome, causing precaucious metabolic senescence in subsequent life.

Keywords:

Hashimoto’s autoimmune thyroiditis, iodine, hyperprolactinemia, hypothyroidism, obesity with rose strias, marfanoid phenotype, metabolic syndrome, infertility, levothyroxine

Downloads

Download data is not yet available.

References

References

Stroev Yu.I., Churilov L.P., Serdyuk I.Yu., Mudzhikova O.M. Autoimmune Thyroiditis: A New Comorbidity of the Most Prevalent Endocrine Disease, Its Prevention and Prediction. In: Poletaev A.B.(ed.), Physiologic Autoimmunity and Preventive Medicine, Bentham Science Publishers, Oak Park a.e.2013, pp. 208–233.

Goncharova E. S., Pestun E.M., Poyarkova A.I., Stroev Yu.I., Churilov L.P. Uric acid, gout and autoimmune thyroiditis: From E. S.London — till nowadays. Clin. Pathophysiol., 2018, vol. 24, no. 4,pp. 56–67. (In Russian)

Stroev Yu.I., Churilov L.P. Hashimoto’s autoimmune thyroiditis, its consequences and comorbidity.In: Shoenfeld Y., Meroni P.L., Churilov L.P. (Eds). Guide in Autoimmune Diseases for General Medical Practice, St. Petersburg, Medkniga-ELBI Publishers, 2017, pp. 298–325. (In Russian)

Churilov L.P., Stroev Yu. I., Serdyuk I.Yu., Kaminova-Mudzhikova O.M., Belyaeva I.V., Gvozdetsky A.N., Nitsa N.A., Mikhailova L.R. Аutoimmune thyroiditis: Сentennial jubilee of a social disease and its comorbidity. Pathophysiology, 2013, vol. 21, pp. 135–145.

Churilov L.P., Sobolevskaia P.A., Stroev Yu.I. Thyroid Gland and Brain: Enigma of Hashimoto’s encephalopathy. Best Pract. & Res. Clin. Endocrinol. & Metab., 2019, vol. 33, no. 6, 101364. https://doi.org/10.1016/j.beem.2019.101364.

Churilov L., Stroev Yu., Ali N., Kaledina E., Utekhin V., Donchenko E. Hyperprolactinemia in pathogenesis of autoimmune infertility. Abstract Auto1-0527). 11th International Congress on Autoimmunity, 14-16 May 2018. Lisbon.

Poyraz B.C., Aksoy C., Balcıoğlu I. Increased incidence of autoimmune thyroiditis in patients with antipsychotic-induced hyperprolactinemia. Europ. Neuropsychopharmacol., 2008, vol. 18, no. 9,pp. 667–672.

Stroev Yu.I., Churilov L.P. Autoimmunity thyroid function and aging: New aspect of understanding.Jap. J.Pathophysiol., 2008, vol. 17, no. 2, p. 35.

Stroev Yu.I., Churilov L.P., Sadov S.A., Zhao Wenlong. Thyroid diseases in senior citizens of St. Petersburg. Wiener klinische Wochenschrift, 2009, vol. 121, no., pp. 71–72.