The The analysis of the secondary structure of the proteins in blood serum of patients with multiple myeloma*

Authors

  • Elena Chikhirzhina Institute of Cytology of the Russian Academy of Sciences, 4, Tikhoretsky pr., St. Petersburg, 194064, Russian Federation
  • Andrei Garifullin Russian Scientific Research Institute of Hematology and Transfusiology, 16, 2-ya Sovetskaya ul., St. Petersburg, 191024, Russian Federation https://orcid.org/0000-0003-0946-383X
  • Aleksey Kuvshinov Russian Scientific Research Institute of Hematology and Transfusiology, 16, 2-ya Sovetskaya ul., St. Petersburg, 191024, Russian Federation
  • Liudmila Plotnikova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0002-3143-7630
  • Alexander Polyanichko Institute of Cytology of the Russian Academy of Sciences, 4, Tikhoretsky pr., St. Petersburg, 194064, Russian Federation;St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Elizabeth Telnaya St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Pavlov First St. Petersburg State Medical University, 6–8, L’va Tolstogo ul., St. Petersburg, 197022, Russian Federation
  • Sergey Voloshin Russian Scientific Research Institute of Hematology and Transfusiology, 16, 2-ya Sovetskaya ul., St. Petersburg, 191024, Russian Federation ; North-Western State Medical University named after I.I.Mechnikov, 41, Kirochnaya ul., St. Petersburg, 191015, Russian Federation ;S.M.Kirov Military Medical Academy, 6, ul. Akademika Lebedeva, St. Petersburg, 194044, Russian Federation https://orcid.org/0000-0003-1784-0375

DOI:

https://doi.org/10.21638/spbu11.2019.435

Abstract

Multiple myeloma (MM) is one of the most common hematologic diseases in the world, which is characterized by the proliferation of clonal plasma cells in the bone marrow producing a monoclonal immunoglobulin. In this research, analysis of the secondary structure of proteins in blood serum of patients with MM and healthy donors was carried out by an infrared spectroscopy method. There were shown a decrease in the average content of α-helical sites and an increase in the number of β-layered structures in blood serum proteins of patients with MM compared to healthy donors.

Keywords:

multiple myeloma, infrared spectroscopy, secondary structure of proteins

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References

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Published

2020-06-15

How to Cite

Chikhirzhina, E., Garifullin, A., Kuvshinov , A. ., Plotnikova , L. ., Polyanichko, A., Telnaya, E., & Voloshin, S. (2020). The The analysis of the secondary structure of the proteins in blood serum of patients with multiple myeloma*. Vestnik of Saint Petersburg University. Medicine, 14(4), 394–398. https://doi.org/10.21638/spbu11.2019.435

Issue

Vol. 14 No. 4 (2019)

Section

Oncology

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.