Analysis of the level of B-cell populations in patients with pulmonary sarcoidosis*

Authors

  • Anna Malkova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Igor Kudryavtsev St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Natalia Basantsova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ;St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation
  • Yulia Zinchenko St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ;St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation
  • Anna Starshinova National Medical Research Center named after V.A.Almazov, 2, ul. Akkuratova, St. Petersburg, 197341, Russian Federation
  • Leonid Churilov St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ;St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation
  • Piotr Yablonskiy St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ;St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.416

Abstract

Sarcoidosis is a granulomatous disease of unknown etiology. The role of B-cells in pathogenesis of sarcoidosis was shown in several studies. The importance of B-lymphocytes activation in sarcoidosis can be confirmed by the efficacy of anti-CD20 treatment. However, there is no data about alteration of certain B-cells subsets. In this study changes in subsets of B-lymphocytes in patients with sarcoidosis (n=37) and a control group (n=30) are analyzed. In patients with sarcoidosis misbalance of B-naïve and B-memory cells was found, the level of B-naïve cells proved to be more than 70.00% and B memory cells less than 30.00% (sensitivity 76%, specificity 70%). Among regulatory B cells there was detected an elevation of CD24+++CD38+++ B cells more than 6.5% (sensitivity 91%, specificity 88%) and CD5+CD27-B cells than 12.45% (sensitivity 76%,specificity 80%). These results show, that in sarcoidosis pathogenesis are involved B-naïve and B-memory cells, that is characteristic for granulomatous diseases, and also regulatory B cells, that produce anti-inflammatory cytokines.

Keywords:

sarcoidosis, autoimmunity, subsets, B cells, humoral immune response

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References


References

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Published

2020-06-15

How to Cite

Malkova, A., Kudryavtsev, I. . ., Basantsova, N., Zinchenko , Y. ., Starshinova, A. ., Churilov, L., & Yablonskiy , P. (2020). Analysis of the level of B-cell populations in patients with pulmonary sarcoidosis*. Vestnik of Saint Petersburg University. Medicine, 14(4), 322–324. https://doi.org/10.21638/spbu11.2019.416

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Section

Internal medicine

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