Family cases of primary Sjogren’s syndrome in monozygous twins*

Александр  Шишкин; Наталия  Басанцова; Михаил  Эрман; Людмила  Слепых

doi:10.21638/spbu11.2019.415

Авторы

Александр Шишкин St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Наталия Басанцова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation https://orcid.org/0000-0002-2957-410X
Михаил Эрман St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Людмила Слепых St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.415

Аннотация

Primary Sjogren’s disease is a systemic disorder of unknown origin with chronic autoimmune inflammation of the exocrine glands and the obligatory involvement of the salivary and lacrimal glands. We present the cases of primary Sjogren’s disease in monozygous twins. These concordant cases suggest the genetic determination of the disease. Early diagnosis of the disease and initiation of immunosuppressive therapy in patient A.prevented the serious complications. The effect of treatment was clearly visible with patient’s cancellation of the basic therapy for almost 6 years, after which the general condition worsened, and a joint pain developed. Long-term therapy with small doses of alkylating cytostatics and glucocorticosteroids positively affects systemic manifestations of the disease, and significantly improves the survival of patients. The presence of complications caused by glucocorticosteroid therapy should be taken into account.

Ключевые слова:

Sjogren’s syndrome, Sicca syndrome, twins, concordance, xerostoma, xerophthalmia

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