Effect of collagen breakdown products on mast cell activity during reparative regeneration

Authors

  • Baira Sandanova Chita State Medical Academy, 39a, ul. Gor’kogo, Chita, 672000, Russian Federation https://orcid.org/0000-0002-6093-0088
  • Tsyndyma Bayashkhalanova Chita State Medical Academy, 39a, ul. Gor’kogo, Chita, 672000, Russian Federation
  • Kondratyeva Eugenia Chita State Medical Academy, 39a, ul. Gor’kogo, Chita, 672000, Russian Federation
  • Obydenko Valentina Chita State Medical Academy, 39a, ul. Gor’kogo, Chita, 672000, Russian Federation
  • Baranchugova Larisa Chita State Medical Academy, 39a, ul. Gor’kogo, Chita, 672000, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.424

Abstract

Immune system including its effector cells and their products (autocoids and autoantibodies) definetly plays an important part in regulation of tissue regeneration. Collagen-based preparations, whose action is due to peptides that have a stimulating effect on the formation of self collagen and bone restoration, as well as indirectly affecting hemostasis and phagocytosis, have gained considerable interest because of frequent bacterial complications of wound healing. The effect of mast cells on the healing process of the wound surface in rats under the influence of collagen dissolution products was assessed in the present study. According to the results, mast cells were found to be activated on the wound surface under the influence of drugs based on collagen breakdown products, which directly caused an acceleration of the reparative regeneration process.

Keywords:

regeneration, mast cells, morphology, skin wound, collagen

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Author Biography

Obydenko Valentina , Chita State Medical Academy, 39a, ul. Gor’kogo, Chita, 672000, Russian Federation

 

 

References


References

Vasiliev A.G., Churilov L.P., Trashkov A.P., Utekhin V.J. Evolution of the immune system and regulatory effects of antibodies. Tsitologiya, 2018, vol. 60, no. 2, pp. 71–80. (In Russian)

Alekseeva N.T., Klochkova S.V., Nikityuk D.B. Morphological characteristics of mast cells during skin regeneration. Orenburgskii meditsinskii vestnik, 2016, no. 3, pp. 13–16. (In Russian)

Alekseeva N.T., Nikityuk D.B., Klochkova S.V. Analytical morphology of reparative regeneration in the skin under the influence of various regional factors. Zhurnal anatomii i gistopatologii, 2015, vol. 4,no. 1, pp. 26–37. (In Russian)

Baranchugova L.M., Obydenko V.I., Rusaeva N. S. Morphological features of wound regeneration under the influence of collagen dissolution products. Mezhdunarodnyi nauchno-issledovatel’skiy zhurnal,2014, no. 6, pp. 61–63. (In Russian)

Bobr O.A., Myadelets O.D., Dubovsky V.V. Dynamics of mast cell population during the wound process in rats subjected to hypobiotic conditions (starvation, hypothermia). Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta, 2006, no. 4, pp. 1–9. (In Russian)

Komi D.E.A., Ribatti D. Mast cell mediated mechanistic pathways in organ transplantation. Europ. J.Pharmacol., 2019, p. 172458.

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Published

2020-06-15

How to Cite

Sandanova, B., Bayashkhalanova, T., Kondratyeva, E., Obydenko, V., & Baranchugova, L. (2020). Effect of collagen breakdown products on mast cell activity during reparative regeneration. Vestnik of Saint Petersburg University. Medicine, 14(4), 350–352. https://doi.org/10.21638/spbu11.2019.424

Issue

Vol. 14 No. 4 (2019)

Section

Internal medicine

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.