Anti-thyroid autoimmunity and psychic disorders*

Authors

  • Polina Sobolevskaia St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Tamara Fedotkina St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 44, pr. Thoreza, St. Petersburg, 194223, Russian Federation
  • Anton Gvozdetskiy St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Evgenia Efimova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Yuri Stroev St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Vladimir Utekhin St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Leonid Churilov St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian FederationжSaint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, 2–4, Ligovsky pr., St. Petersburg, 191036, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.407

Abstract

Thyroid hormones are essential for normal brain development and function, also regulatingsome processes in im mune system. The vicious effect of hypothyroidism for central nervous system displayed in myxoedema is known for many decades, but there is a CNS disorder related to autoimmune thyroid disease and not merely dependent on hypothyroidism. That is Hashimoto’s encephalopathy (steroid-responsive encephalopathy of autoimmune thyroiditis) — an enigmatic combination of cognitive, mood and motor disorders with psychotic symptoms, which pathogenesis is still unclear. The article describes natural history of this entity, its epidemiology, clinical and laboratory manifestation, and compares several existing theories of its pathogenesis with appropriate pros and contras. Vascular, dyshormonal and non-vascular autoimmune links of Hashimoto’s encephalopathy pathogenesis are discussed in intermingled discourse. The attempt to construct a synthetic concept of Hashimoto’s encephalopathy pathogenesis is given. The experience of authors based on investigation of clinical, endocrine and immunological parameters of 17 cases of autoimmune thyroiditis with schizophrenia-like manifestations is described, correlations are explored between immunoendocrine and psychic manifestations of disease

Keywords:

autoantibodies, Hashimoto’s thyroiditis, Hashimoto’s encephalopathy, steroidresponsive encephalopathy associated with autoimmune thyroiditis, schizophrenia, autoimmune encephalitis, psychosis

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References


References

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Published

2020-06-15

How to Cite

Sobolevskaia , P. ., Fedotkina , T. . ., Gvozdetskiy, A. ., Efimova, E., Stroev, Y. ., Utekhin, V. ., & Churilov , L. . (2020). Anti-thyroid autoimmunity and psychic disorders*. Vestnik of Saint Petersburg University. Medicine, 14(4), 288–291. https://doi.org/10.21638/spbu11.2019.407

Issue

Vol. 14 No. 4 (2019)

Section

Neurology. Neurosurgery. Psychiatry

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.

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