ADIPOKINE SIGNALING IN BRONCHIAL ASTHMA IN COMBINATION WITH OVERWEIGHT
DOI:
https://doi.org/10.21638/11701/spbu11.2016.301.Abstract
We examined 173 overweight patients with bronchial asthma (BA) using ELISA method, identifying leptin, adiponectin and resistin from samples of plasma and sputum. The idea that BA is heterogeneous in relation to adipokines signaling dependant on the variant of BA, severity of disease, sex and age of patients has been advanced. The imbalance of proinflammatory (leptin, resistin) and antiinflammatory (adiponectin) signaling molecules, at the system level, organ level (in sputum) and target cells (mononuclear cells peripheral blood) was revealed. The identification of the phenomenon of presence of adipokines (leptin and resistin) in the sputum is considered as one of mechanisms of adipokines elimination during exacerbation of BA, which allows to extend the understanding nonrespiratory lung function in BA. Refs 15. Figs 5. Tabl. 11.
Keywords:
bronchial asthma, adipokine signaling, leptin, adiponectin, resistin, plasma, sputum
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Литература
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References
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Myers M. G ., Gowley M. A., Munzberg H. Mechanisms of leptin action and leptin resistance. Аnnu. Rev. Physiol., 2008, vol. 70, pp. 537–556.
Sutherland T. J., Sears M. R., McLachlan C. R., Poulton R., Hancox R. J. Leptin, adiponectin, and asthma: findings from a population-based cohort study. Ann. Allergy Asthma Immunol., 2009, vol. 103, no. 2,pp. 101–107.
Gupta S., Agrawal S., Gollapudi S. Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans. Immun. Ageing., 2013, vol. 10, no. 1, p. 3.
Sood A., Shore S. A. Adiponectin, leptin, and resistin in asthma: basic mechanisms through population studies. J. Allergy, 2013, vol. 2013, pp. 1–15.
Lessard A., St-Laurent J., Turcotte H., Boulet L. P. Leptin and adiponectin in obese and non-obese subjects with asthma. Biomarkers, 2011, vol. 16, no. 3, pp. 271–273.
Garcia Р., Sood A. Adiponectin in pulmonary disease and critically ill patients. Curr. Med. Chem.,2012, vol. 19, no. 32, pp. 5493–5500.
Lehrke M., Reilly M. P., Millington S. C., Iqbal N., Rader D. J., Lazar M. A. An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med., 2004, vol. 1, p. e45.
Lu S. C., Shieh W. Y., Chen C. Y., Hsu S. C., Chen H. L. Lipopolysaccharide increases resistin gene expression in vivo and in vitro. FEBS Letters, 2002, vol. 530, pp. 158–162.
Kim S. H ., Sutherland E. R., Gelfand E. W. Is there link between obesity and asthma? Allergy Asthma Immunol. Res., 2014, vol. 6, no. 3, pp. 189–195.
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Published
2017-01-16
How to Cite
Минеев, В. Н., Лалаева, Т. М., & Нестерович, И. И. (2017). ADIPOKINE SIGNALING IN BRONCHIAL ASTHMA IN COMBINATION WITH OVERWEIGHT. Vestnik of Saint Petersburg University. Medicine, 11(3), 5–19. https://doi.org/10.21638/11701/spbu11.2016.301.
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Internal medicine
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Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.
