The influence of selective serotonin reuptake inhibitors on behavior of adult Danio rerio in experimental depression
DOI:
https://doi.org/10.21638/spbu11.2019.301Abstract
Depression is one the most common form of mental diseases. Due to epidemiological studies,it is common in different age groups including young people. Depression pathogenesis from the point of system perspective view consists of morphofunctional and pathopsychological components. The former can be divided into neuroanatomical, neurophysiological, neurochemical parts. Laboratory animals as experimental models are an invaluable tool for investigating pathogenesis of depressive disorders and creating potential treatments. In our study Danio rerio was used as an experimental model of depression. In fish schools during separation in pairs, anxious and aggressive behavior towards each other was manifested. It contributes to formation of dominant-subordinate relationships. Before administration of fluoxetine and sertraline in all the groups studied, the lower level of fish swimming was observed. They were hyperactive. Aggressive behavior towards each other was not observed. On the third day of the experiment behavior of the fish in groups with fluoxetine and sertraline was different. In group with sertraline 25 % of fishes come up to average level. In group with fluoxetine fishes remained at the bottom of the aquarium. On the fifth day of the experiment in the group with sertraline 25 % of fishes had an abnormal craniocaudal position of the body in space.
Keywords:
selective serotonin reuptake inhibitors (SSRI), Danio rerio, depression
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Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.