Titer of antiphospholipid autoantibodies. Is it connected with clinical manifestation?

Авторы

  • Кирилл Чудотворов Pavlov First Saint Petersburg State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation
  • Сергей Чепанов D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation
  • Екатерина Корнюшина D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation
  • Екатерина Орлова D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation
  • Сергей Селков D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.428

Аннотация

Antiphospholipid syndrome is a systemic autoimmune disease characterized by persistent antiphospholipid autoantibodies, the development of thrombophilic conditions and recurrent pregnancy loss. In this study the incidence of antiphospholipid antibodies of different titers among the women with one or more episodes of fetal loss in the anamnesis was determined.According the data obtained, autoantibodies in medium and high titers for cardiolipin and beta-2-glycoprotein-1 were more common among the women with two or more episodes of recurrent pregnancy loss compared with the women who have only one episode of pregnancy
loss. In a group of women with one episode of pregnancy loss, antibodies in high titers were not detected. Based on this, it can be assumed that autoantibodies in medium and high titers have the most significant pathogenetic effect on the outcome of pregnancy. In contrast, autoantibodies in low titers are considered to be dubious and clinically insignificant.

Ключевые слова:

antiphospholipid syndrome, antiphospholipid autoantibodies, recurrent pregnancy loss, miscarriage

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References

Chepanov S.V., Krivonos M.I., Arzhanova O.N., Shlyakhtenko T.N., Saidov N.Kh., Kornyushina E.A., Chudotvorov K.N., Sedikhin V.Yu., Selkov S.A. Characteristics of autoantibodies associated with recurrent Pregnancy loss. Akusherstvo i ginekologiia, 2019, no. 3, pp. 72–77. (In Russian)

Meroni P.L., Borghi M.O., Grossi C., Chighizola C.B., Durigutto P., Tedesco F. Obstetric and Vascular Antiphospholipid Syndrome: Same Antibodies but Different Diseases? Nat. Rev. Rheumatol., 2018,vol. 14, no. 7, pp. 433–440.

Tkachenko O.Yu., Lapin S.V., Shmonin A.A., Solovyova L.N., Bondareva E.A., Sel’kov S.A., Chepanov S.V., Totolian A.A., Roggenbuck D. Ranging of antiphospolipid antibodies in the patients with thrombophilia and recurrent miscarriage. Meditsinskaia immunologiia, 2018, vol. 20, no. 5, pp. 753–762. (In Russian)

Yu Song, Hai-Yan Wang, Jie Qiao, Ping Liuх, Hong-Bin Chi. Antiphospholipid Antibody Titers and Clinical Outcomes in Patients With Recurrent Miscarriage and Antiphospholipid Antibody Syndrome: A Prospective Study. Chin. Med. J., 2017, vol. 5, no. 130 (3), pp. 267–272.

Howard J.A. Recurrent Pregnancy Loss: Causes, Controversies, and Treatment. New York, CRC Press Publishers, 2015.

Загрузки

Опубликован

15.06.2020

Как цитировать

Чудотворов, К., Чепанов, С., Корнюшина, Е., Орлова, Е., & Селков, С. (2020). Titer of antiphospholipid autoantibodies. Is it connected with clinical manifestation?. Вестник Санкт-Петербургского университета. Медицина, 14(4), 364–366. https://doi.org/10.21638/spbu11.2019.428

Выпуск

Том 14 № 4 (2019)

Раздел

Акушерство и гинекология

Лицензия

Статьи журнала «Вестник Санкт-Петербургского университета. Медицина» находятся в открытом доступе и распространяются в соответствии с условиями Лицензионного Договора с Санкт-Петербургским государственным университетом, который бесплатно предоставляет авторам неограниченное распространение и самостоятельное архивирование.

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