Titer of antiphospholipid autoantibodies. Is it connected with clinical manifestation?

Authors

  • Kirill Chudotvorov Pavlov First Saint Petersburg State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation
  • Sergey Chepanov D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation
  • Ekaterina Kornyushina D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation
  • Ekaterina Orlova D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation
  • Sergey Selkov D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya lin., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.428

Abstract

Antiphospholipid syndrome is a systemic autoimmune disease characterized by persistent antiphospholipid autoantibodies, the development of thrombophilic conditions and recurrent pregnancy loss. In this study the incidence of antiphospholipid antibodies of different titers among the women with one or more episodes of fetal loss in the anamnesis was determined.According the data obtained, autoantibodies in medium and high titers for cardiolipin and beta-2-glycoprotein-1 were more common among the women with two or more episodes of recurrent pregnancy loss compared with the women who have only one episode of pregnancy
loss. In a group of women with one episode of pregnancy loss, antibodies in high titers were not detected. Based on this, it can be assumed that autoantibodies in medium and high titers have the most significant pathogenetic effect on the outcome of pregnancy. In contrast, autoantibodies in low titers are considered to be dubious and clinically insignificant.

Keywords:

antiphospholipid syndrome, antiphospholipid autoantibodies, recurrent pregnancy loss, miscarriage

Downloads

Download data is not yet available.
 

References


References

Chepanov S.V., Krivonos M.I., Arzhanova O.N., Shlyakhtenko T.N., Saidov N.Kh., Kornyushina E.A., Chudotvorov K.N., Sedikhin V.Yu., Selkov S.A. Characteristics of autoantibodies associated with recurrent Pregnancy loss. Akusherstvo i ginekologiia, 2019, no. 3, pp. 72–77. (In Russian)

Meroni P.L., Borghi M.O., Grossi C., Chighizola C.B., Durigutto P., Tedesco F. Obstetric and Vascular Antiphospholipid Syndrome: Same Antibodies but Different Diseases? Nat. Rev. Rheumatol., 2018,vol. 14, no. 7, pp. 433–440.

Tkachenko O.Yu., Lapin S.V., Shmonin A.A., Solovyova L.N., Bondareva E.A., Sel’kov S.A., Chepanov S.V., Totolian A.A., Roggenbuck D. Ranging of antiphospolipid antibodies in the patients with thrombophilia and recurrent miscarriage. Meditsinskaia immunologiia, 2018, vol. 20, no. 5, pp. 753–762. (In Russian)

Yu Song, Hai-Yan Wang, Jie Qiao, Ping Liuх, Hong-Bin Chi. Antiphospholipid Antibody Titers and Clinical Outcomes in Patients With Recurrent Miscarriage and Antiphospholipid Antibody Syndrome: A Prospective Study. Chin. Med. J., 2017, vol. 5, no. 130 (3), pp. 267–272.

Howard J.A. Recurrent Pregnancy Loss: Causes, Controversies, and Treatment. New York, CRC Press Publishers, 2015.

Downloads

Published

2020-06-15

How to Cite

Chudotvorov, K., Chepanov , S. ., Kornyushina , E., Orlova , E. ., & Selkov, S. (2020). Titer of antiphospholipid autoantibodies. Is it connected with clinical manifestation?. Vestnik of Saint Petersburg University. Medicine, 14(4), 364–366. https://doi.org/10.21638/spbu11.2019.428

Issue

Vol. 14 No. 4 (2019)

Section

Obstetrics and ginecology

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.

Most read articles by the same author(s)