Analysis of the application of laboratory tests in the diagnosis of diseases of connective tissue

Авторы

  • Диана Бацаца INVITRO-SPb LTD, 57, Dnepropetrovskaya ul., St. Petersburg, 196105, Russian Federation
  • Татьяна Булгакова INVITRO-SPb LTD, 57, Dnepropetrovskaya ul., St. Petersburg, 196105, Russian Federation https://orcid.org/0000-0002-4513-7364
  • Сергей Бардаков S.M.Kirov Military Medical Academy, 6, ul. Academika Lebedeva, St. Petersburg, 194044, Russian Federation https://orcid.org/0000-0002-3804-6245

DOI:

https://doi.org/10.21638/spbu11.2019.426

Аннотация

The determination of antinuclear antibodies is included in the criteria for the diagnosis of connective tissue diseases, differential diagnosis and determines the prognosis and treatment tactics of the patient. The existing strategy for laboratory diagnosis of connective tissue diseases involves screening (ANA Hep-2 cell + ENA / ELISA), followed by the selection of refinement tests (ELISA, immunoblot). The assessment of the actually used algorithms, however, revealed that every third patient was assigned almost all available tests simultaneously to confirm a connective tissue disease. Rational screening was performed in 1/3 of the cases. Low frequency of application of ANA immunoblots significantly reduced the effectiveness of diagnosis. It is advisable to provide more information about the primary screening methods for connective tissue diseases of practicing doctors, namely therapists and general practitioners, who act as the primary diagnostic link for this category of patients.

Ключевые слова:

diffuse connective tissue diseases, screening, antinuclear antibodies

Скачивания

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Биография автора

Диана Бацаца, INVITRO-SPb LTD, 57, Dnepropetrovskaya ul., St. Petersburg, 196105, Russian Federation 

 

Библиографические ссылки


References

Shoenfeld Y., Meroni P.L., Churilov L.P. (Eds). Manual on Autoimmune Diseases for General Medical Practice. St. Petersburg, Medkniga-ELBI Publ., 2017, pp. 25–140. (In Russian)

Lapin S.V., Totolyan A.A. Immunological Laboratory Diagnostics of Autoimmune Diseases. St. Petersburg, Chelovek Publ., 2010, pp. 31–60. (In Russian)

Damoiseaux J., Luis E.C., Orlando G.C. (Eds). Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective, 2019

Загрузки

Опубликован

15.06.2020

Как цитировать

Бацаца, Д., Булгакова, Т., & Бардаков, С. (2020). Analysis of the application of laboratory tests in the diagnosis of diseases of connective tissue. Вестник Санкт-Петербургского университета. Медицина, 14(4), 357–360. https://doi.org/10.21638/spbu11.2019.426

Выпуск

Том 14 № 4 (2019)

Раздел

Клиническая лабораторная диагностика

Лицензия

Статьи журнала «Вестник Санкт-Петербургского университета. Медицина» находятся в открытом доступе и распространяются в соответствии с условиями Лицензионного Договора с Санкт-Петербургским государственным университетом, который бесплатно предоставляет авторам неограниченное распространение и самостоятельное архивирование.