Analysis of the application of laboratory tests in the diagnosis of diseases of connective tissue

Authors

  • Diana Batsatsa INVITRO-SPb LTD, 57, Dnepropetrovskaya ul., St. Petersburg, 196105, Russian Federation
  • Tatiana Bulgakova INVITRO-SPb LTD, 57, Dnepropetrovskaya ul., St. Petersburg, 196105, Russian Federation https://orcid.org/0000-0002-4513-7364
  • Sergei Bardakov S.M.Kirov Military Medical Academy, 6, ul. Academika Lebedeva, St. Petersburg, 194044, Russian Federation https://orcid.org/0000-0002-3804-6245

DOI:

https://doi.org/10.21638/spbu11.2019.426

Abstract

The determination of antinuclear antibodies is included in the criteria for the diagnosis of connective tissue diseases, differential diagnosis and determines the prognosis and treatment tactics of the patient. The existing strategy for laboratory diagnosis of connective tissue diseases involves screening (ANA Hep-2 cell + ENA / ELISA), followed by the selection of refinement tests (ELISA, immunoblot). The assessment of the actually used algorithms, however, revealed that every third patient was assigned almost all available tests simultaneously to confirm a connective tissue disease. Rational screening was performed in 1/3 of the cases. Low frequency of application of ANA immunoblots significantly reduced the effectiveness of diagnosis. It is advisable to provide more information about the primary screening methods for connective tissue diseases of practicing doctors, namely therapists and general practitioners, who act as the primary diagnostic link for this category of patients.

Keywords:

diffuse connective tissue diseases, screening, antinuclear antibodies

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Author Biography

Diana Batsatsa, INVITRO-SPb LTD, 57, Dnepropetrovskaya ul., St. Petersburg, 196105, Russian Federation 

 

References


References

Shoenfeld Y., Meroni P.L., Churilov L.P. (Eds). Manual on Autoimmune Diseases for General Medical Practice. St. Petersburg, Medkniga-ELBI Publ., 2017, pp. 25–140. (In Russian)

Lapin S.V., Totolyan A.A. Immunological Laboratory Diagnostics of Autoimmune Diseases. St. Petersburg, Chelovek Publ., 2010, pp. 31–60. (In Russian)

Damoiseaux J., Luis E.C., Orlando G.C. (Eds). Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective, 2019

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Published

2020-06-15

How to Cite

Batsatsa, D., Bulgakova, T., & Bardakov , S. (2020). Analysis of the application of laboratory tests in the diagnosis of diseases of connective tissue. Vestnik of Saint Petersburg University. Medicine, 14(4), 357–360. https://doi.org/10.21638/spbu11.2019.426

Issue

Vol. 14 No. 4 (2019)

Section

Clinical laboratory diagnostics

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.