Apoptosis and autophagy, as inherent components of autoimmunity in the acute period of ischemic stroke

Анна Луговая; Наталия Калинина; Евгений Баранцевич; Анастасия Артемова

doi:10.21638/spbu11.2019.409

Авторы

Анна Владимировна Луговая Pavlov First Saint Petersburg State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation https://orcid.org/0000-0002-7690-9064
Наталия Михайловна Калинина Pavlov First Saint Petersburg State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation 2 Nikiforov Russian Center of Emergency and Radiation Medicine, 4/2, ul. Akademika Lebedeva, St. Petersburg, 194044, Russian Federation
Евгений Робертович Баранцевич Pavlov First Saint Petersburg State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation
Артемова Анастасия Витальевна Pavlov First Saint Petersburg State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.409

Аннотация

Acute ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. It is known that apoptosis, autophagy, and necrosis are the main mechanisms of neuronal death after acute ischemic stroke. Modulation of apoptosis and autophagy in the acute period of the disease, as components of increased immunological reactivity, can contribute to the survival of neurons, preventing their delayed death. A comparative assessment of the dynamics of apoptosis and autophagy markers was performed for better understanding of the crossinteractions between these processes. The results indicate that several markers of apoptosis and autophagy are involved at various stages of the acute period of ischemic stroke and that
enhanced spontaneous apoptosis of peripheral blood mononuclear cells acts as one of immunosuppression factors in acute period of the disease. The obtained data confirm the active participation of autophagy, pro- and antiapoptotic processes in the autoimmune response and the formation of delayed neuronal death after acute ischemic stroke.

Ключевые слова:

autoimmunity, inflammation, apoptosis, autophagy, acute ischemic stroke, serum level of protein p53, Bcl-2, Beclin 1, LC3

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