Apoptosis and autophagy, as inherent components of autoimmunity in the acute period of ischemic stroke

Authors

  • Anna Vladimirovna Lugovaya Pavlov First Saint Petersburg State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation https://orcid.org/0000-0002-7690-9064
  • Natalia Mikhailovna Kalinina Pavlov First Saint Petersburg State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation ; Nikiforov Russian Center of Emergency and Radiation Medicine, 4/2, ul. Akademika Lebedeva, St. Petersburg, 194044, Russian Federation
  • Evgeny Robertovich Barancevich Pavlov First Saint Petersburg State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation
  • Artemova Anastasiya Vital'evna, Pavlov First Saint Petersburg State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.409

Abstract

Acute ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. It is known that apoptosis, autophagy, and necrosis are the main mechanisms of neuronal death after acute ischemic stroke. Modulation of apoptosis and autophagy in the acute period of the disease, as components of increased immunological reactivity, can contribute to the survival of neurons, preventing their delayed death. A comparative assessment of the dynamics of apoptosis and autophagy markers was performed for better understanding of the crossinteractions between these processes. The results indicate that several markers of apoptosis and autophagy are involved at various stages of the acute period of ischemic stroke and that
enhanced spontaneous apoptosis of peripheral blood mononuclear cells acts as one of immunosuppression factors in acute period of the disease. The obtained data confirm the active participation of autophagy, pro- and antiapoptotic processes in the autoimmune response and the formation of delayed neuronal death after acute ischemic stroke.

Keywords:

autoimmunity, inflammation, apoptosis, autophagy, acute ischemic stroke, serum level of protein p53, Bcl-2, Beclin 1, LC3

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References


References

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Published

2020-06-15

How to Cite

Lugovaya, A., Kalinina, . N. ., Barancevich, . E. ., & Artemova, . A. . (2020). Apoptosis and autophagy, as inherent components of autoimmunity in the acute period of ischemic stroke. Vestnik of Saint Petersburg University. Medicine, 14(4), 295–298. https://doi.org/10.21638/spbu11.2019.409

Issue

Vol. 14 No. 4 (2019)

Section

Neurology. Neurosurgery. Psychiatry

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.