Pathways of information exchange between immune and nervous systems*

Елена Корнева

doi:10.21638/spbu11.2019.402

Авторы

Елена Корнева St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Institute of Experimental Medicine, 12, ul. Akademika Pavlova, St. Petersburg, 197376, Russian Federation https://orcid.org/0000-0002-4999-5913

DOI:

https://doi.org/10.21638/spbu11.2019.402

Аннотация

An exchange of information between the immune and nervous systems, via main sympathetic and parasympathetic afferent and efferent ways of signal transmission providing the possibility of the constant dialogue between these systems. This article addresses new information about immune system innervation and its connections with the central nervous system. Vagal nerve appears to play a key role in this interaction. The antigen challenge induces cytokines production (IL-1, TNFα, IL-6, and IFNγ etc), which receptors are present on the peripheral neurons and terminals of n. vagus, which innervate many internal organs. These signals are transmitted to the neurons of central nervous system. Recent data are used to develop methods for correcting the functions of the immune system in allergic and autoimmune diseases, affecting the mechanisms of their regulation. For example, activation of parasympathetic system leads to suppression of the development of inflammation

Ключевые слова:

neuroimmune interactions, neuroinflammation, inflammatory reflex, innovative treatment

Скачивания

Данные скачивания пока недоступны.

Библиографические ссылки

References

Korneva E.A. Concluding Remarks.Cytokines and the Brain, Elsevier, 2008, vol. 6, pp. 567–570.

Perekrest S.V., Shainidze K.Z., Loskutov Yu.V., Abramova T.V., Novikova N. S., Korneva E.A. Immunoreactivity of orexin-containing hypothalamus neurons and the level of preproorexin gene expression in them after lipopolysaccharide administration.Rossiiskii fiziologicheskii zhurnal imeniI. M. Sechenova, 2011, vol. 97, no. 6, pp. 573–579. (In Russian)

Dénes A., Boldogkoi Z., Uhereczky G., Hornyák A., Rusvai M., Palkovits M., Kovács K.J. Central autonomic control of the bone marrow: multisynaptic tract tracing by recombinant pseudorabies virus. Neuroscience,2005, vol. 134, no. 3, pp. 947–963.

Goehler L.E., Gaykema R.P.A., Hammack S.E., Maier S.F., Watkins L.R. Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve. Brain Res.,1998, vol. 804, no. 2,pp. 306–310.

Berthoud H.R., Neuhuber W.L. Functional and chemical anatomy of the afferent vagal system.Auton.Neurosci.,2000, vol. 85, no. 1–3, pp. 1–17.

Korneva E.A., Shekoyan V.A.Regulation of protective functions of the body.Leningrad, Nauka Publ.,1982. 138 p. (In Russian)

Steinberg B.E., Tracey K.J., Slutsky A. S. Bacteria and the neural code. N. Engl. J. Med., 2014, vol. 371,no. 22, pp. 2131–2133.

Ordovas-Montanes J., Rakoff-Nahoum S., Huang S., Riol-Blanco L., Barreiro O., von Andrian U.H.The regulation of immunological processes by peripheral neurons in homeostasis and disease.Trendsin Immunology,2015, vol. 36, no. 10, pp. 578–604.

Steinman L. Immunology of relapse and remission in multiple sclerosis.Annual Reviews of Immunology,2014, vol. 32, pp. 257–281.

Bonaz B., Sinniger V., Pellissier S. Vagus nerve stimulation: a new promising therapeutic tool in inflammatory bowel disease.J. Intern. Med.,2017, vol. 282, no. 1, pp. 46–63.