Pathways of information exchange between immune and nervous systems*

Authors

  • Elena Korneva St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Institute of Experimental Medicine, 12, ul. Akademika Pavlova, St. Petersburg, 197376, Russian Federation https://orcid.org/0000-0002-4999-5913

DOI:

https://doi.org/10.21638/spbu11.2019.402

Abstract

An exchange of information between the immune and nervous systems, via main sympathetic and parasympathetic afferent and efferent ways of signal transmission providing the possibility of the constant dialogue between these systems. This article addresses new information about immune system innervation and its connections with the central nervous system. Vagal nerve appears to play a key role in this interaction. The antigen challenge induces cytokines production (IL-1, TNFα, IL-6, and IFNγ etc), which receptors are present on the peripheral neurons and terminals of n. vagus, which innervate many internal organs. These signals are transmitted to the neurons of central nervous system. Recent data are used to develop methods for correcting the functions of the immune system in allergic and autoimmune diseases, affecting the mechanisms of their regulation. For example, activation of parasympathetic system leads to suppression of the development of inflammation

Keywords:

neuroimmune interactions, neuroinflammation, inflammatory reflex, innovative treatment

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References


References

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Published

2020-06-15

How to Cite

Korneva, . E. (2020). Pathways of information exchange between immune and nervous systems*. Vestnik of Saint Petersburg University. Medicine, 14(4), 268–272. https://doi.org/10.21638/spbu11.2019.402

Issue

Vol. 14 No. 4 (2019)

Section

Pathological physiology

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.