Evaluation of Toll-like receptors expression in rat brain under alcoholization and ethanol withdrawal

Авторы

  • Сергей Ереско Национальный исследовательский университет ИТМО https://orcid.org/0000-0002-0269-6078
  • Мария Спешилова St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation
  • Кирилл Леонченко St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation
  • Татьяна Черных St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation https://orcid.org/0000-0003-2834-5468
  • Марат Айрапетов 2 St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation ; Institute of Experimental Medicine, 12, ul. Akademika Pavlova, St. Petersburg, 197376, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.412

Аннотация

In experiments on rodents and in the study of postmortem brain samples of people suffering from alcoholism, it was shown that ethanol increases the expression of Toll-like receptors in the brain, which persists for a long time. Toll-like receptors are known to be also involved in the development of autoimmune reactions. In the present study the expression of Toll-like receptors in hippocampus, amygdala, and medial entorhinal cortex of rats during prolonged alcoholization and alcohol withdrawal was assessed. In the group of prolonged alcoholization with 20% ethanol for 1 month there was no change in Toll-like receptors mRNA levels in the studied rat brain structures, except for a slight decrease in Toll-like receptor 3 mRNA levels in the hippocampus of alcoholized rats and its slight increase in medial entorhinal cortex. However, Toll-like receptors gene expression undergoes changes in all rat brain structures studied during alcohol withdrawal.

Ключевые слова:

rat, brain, alcoholism, withdrawal syndrome, TLRs

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Библиографические ссылки


References

Airapetov M.I., Eresko S.O. Alcohol consumption leads to activation of the neuroimmune system via the HMGB1 protein. Narcologiya, 2019, vol. 18, no. 5, pp. 96–102. (In Russian)

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Crews F.T., Walter T.J.Coleman L.G., Vetreno R.P. Toll-like receptor signaling and stages of addiction. Psychopharmacology, 2017, vol. 234, no. 9–10, pp. 1483–1498.

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Hossain M.J., Tanasescu R., Gran B. Innate immune regulation of autoimmunity in multiple sclerosis: Focus on the role of Toll-like receptor 2. Journal of Neuroimmunology, 2017, no. 304, pp. 11–20.

Загрузки

Опубликован

15.06.2020

Как цитировать

Ереско, С., Спешилова , М., Леонченко, К., Черных , Т., & Айрапетов , М. (2020). Evaluation of Toll-like receptors expression in rat brain under alcoholization and ethanol withdrawal. Вестник Санкт-Петербургского университета. Медицина, 14(4), 307–309. https://doi.org/10.21638/spbu11.2019.412

Выпуск

Том 14 № 4 (2019)

Раздел

Неврология. Нейрохирургия. Психиатрия

Лицензия

Статьи журнала «Вестник Санкт-Петербургского университета. Медицина» находятся в открытом доступе и распространяются в соответствии с условиями Лицензионного Договора с Санкт-Петербургским государственным университетом, который бесплатно предоставляет авторам неограниченное распространение и самостоятельное архивирование.