Evaluation of Toll-like receptors expression in rat brain under alcoholization and ethanol withdrawal

Authors

  • Sergei Eresko St. Petersburg National Research University of Information Technologies, Mechanics and Optics, 49, Kronverkskii pr., St. Petersburg, 197101, Russian Federation https://orcid.org/0000-0002-0269-6078
  • Maria Speshilova St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation
  • Kirill Leonchenko St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation
  • Tatyana Chernich St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation https://orcid.org/0000-0003-2834-5468
  • Marat Airapetov 2 St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation ; Institute of Experimental Medicine, 12, ul. Akademika Pavlova, St. Petersburg, 197376, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.412

Abstract

In experiments on rodents and in the study of postmortem brain samples of people suffering from alcoholism, it was shown that ethanol increases the expression of Toll-like receptors in the brain, which persists for a long time. Toll-like receptors are known to be also involved in the development of autoimmune reactions. In the present study the expression of Toll-like receptors in hippocampus, amygdala, and medial entorhinal cortex of rats during prolonged alcoholization and alcohol withdrawal was assessed. In the group of prolonged alcoholization with 20% ethanol for 1 month there was no change in Toll-like receptors mRNA levels in the studied rat brain structures, except for a slight decrease in Toll-like receptor 3 mRNA levels in the hippocampus of alcoholized rats and its slight increase in medial entorhinal cortex. However, Toll-like receptors gene expression undergoes changes in all rat brain structures studied during alcohol withdrawal.

Keywords:

rat, brain, alcoholism, withdrawal syndrome, TLRs

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References


References

Airapetov M.I., Eresko S.O. Alcohol consumption leads to activation of the neuroimmune system via the HMGB1 protein. Narcologiya, 2019, vol. 18, no. 5, pp. 96–102. (In Russian)

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Published

2020-06-15

How to Cite

Eresko , S., Speshilova , M. ., Leonchenko, K., Chernich, T. ., & Airapetov, M. (2020). Evaluation of Toll-like receptors expression in rat brain under alcoholization and ethanol withdrawal. Vestnik of Saint Petersburg University. Medicine, 14(4), 307–309. https://doi.org/10.21638/spbu11.2019.412

Issue

Vol. 14 No. 4 (2019)

Section

Neurology. Neurosurgery. Psychiatry

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.