Multiplex immunoassay of the cytokine profile in systemic lupus erythematosus: Relationship with disease activity and level of antinuclear antibodies

Авторы

  • Елена Александрова ГБУЗ Московский клинический научно-практический центр имени А.С. Логинова ДЗМ
  • Александр Новиков A. S.Loginov Moscow Clinical Research and Practical Center Moscow Healthcare Department, 86, shosse Enthusiastov, Moscow, 111123, Russian Federation
  • Жанна Верижникова V.A.Nasonova Research Institute of Rheumatology, 34A, Kashirskoye shosse, Moscow, 115522, Russian Federation
  • Татьяна Панафидина V.A.Nasonova Research Institute of Rheumatology, 34A, Kashirskoye shosse, Moscow, 115522, Russian Federation
  • Галина Лукина A. S.Loginov Moscow Clinical Research and Practical Center Moscow Healthcare Department, 86, shosse Enthusiastov, Moscow, 111123, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.414

Аннотация

Systemic lupus erythematosus is an autoimmune disease characterized by pathological activation of B- and T-cells, the formation of antinuclear antibodies, and dysregulation of cytokine production. The aim of the work was to study the cytokine profiles in patients with this disease in comparison with the disease activity and levels of antinuclear antibodies when using multiplex immunoassay technology, which has a high analytical sensitivity and provide the possibility of simultaneous determination of a large number of biomarkers. Hyperproduction of chemokines IP-10 and MCP-1, regulated by IFN, was associated with high activity of the disease and increased production of antinuclear antibodies. Various immunological subtypes of systemic lupus erythematosus were identified according to the cytokine profile, which reflects the heterogeneity of this multifactorial disease.

Ключевые слова:

systemic lupus erythematosus, cytokine profile, antinuclear antibodies, SLEDAI-2K, multiplex immunoassay

Скачивания

Данные скачивания пока недоступны.
 

Библиографические ссылки


References

Liu C.C., Kao A.H., Manzi S., Ahearn J.M. Biomarkers in systemic lupus erythematosus: challenges and prospects for the future. Ther. Adv. Musculosceletal Dis., 2013, vol. 5, no. 4, pp. 210–133.

Zharkova O., Celhar T., Cravens P.D., Satterthwaite A.B., Fairhurst A.M., Davis L. S. Pathways leading to an immunological disease: systemic lupus erythematosus.Rheumatology (Oxford), 2017, vol. 56 (suppl_1), pp. 55–66.

Li Q.Z., Zhou J., Lian Y., Zhang B., Branch V.K., Carr-Johnson F., Karp D.R., Mohan C., Wakeland E.K., Olsen N.J. Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes. Clin. Exp. Immunol., 2010, vol. 159, no. 3, pp. 281–291.

Pacheco Y., Barahona-Correa J., Monsalve D.M., Acosta-Ampudia Y., Rojas M., Rodríguez Y., Saavedra J., Rodríguez-Jiménez M., Mantilla R.D., Ramírez-Santana C., Molano-González N., Anaya J.M. Cytokine and autoantibody clusters interaction in systemic lupus erythematosus. J.Transl. Med., 2017,vol. 15, no. 1, pp. 239.

Reynolds J.A., McCarthy E.M., Haque S., Ngamjanyaporn P., Sergeant J.C., Lee E., Lee E., Kilfeather S.A., Parker B., Bruce I.N. Cytokine profiling in active and quiescent SLE reveals distinct patient subpopulations. Arthritis Res. Ther., 2018, vol. 20, no. 1, p. 173.

Загрузки

Опубликован

15.06.2020

Как цитировать

Александрова, Е., Новиков, А., Верижникова, Ж., Панафидина, Т., & Лукина, Г. (2020). Multiplex immunoassay of the cytokine profile in systemic lupus erythematosus: Relationship with disease activity and level of antinuclear antibodies. Вестник Санкт-Петербургского университета. Медицина, 14(4), 314–317. https://doi.org/10.21638/spbu11.2019.414

Выпуск

Том 14 № 4 (2019)

Раздел

Внутренние болезни

Лицензия

Статьи журнала «Вестник Санкт-Петербургского университета. Медицина» находятся в открытом доступе и распространяются в соответствии с условиями Лицензионного Договора с Санкт-Петербургским государственным университетом, который бесплатно предоставляет авторам неограниченное распространение и самостоятельное архивирование.