Multiplex immunoassay of the cytokine profile in systemic lupus erythematosus: Relationship with disease activity and level of antinuclear antibodies

Authors

  • Elena Aleksandrova A. S.Loginov Moscow Clinical Research and Practical Center Moscow Healthcare Department, 86, shosse Enthusiastov, Moscow, 111123, Russian Federation
  • Aleksandr Novikov A. S.Loginov Moscow Clinical Research and Practical Center Moscow Healthcare Department, 86, shosse Enthusiastov, Moscow, 111123, Russian Federation
  • Zhanna Verizhnikova V.A.Nasonova Research Institute of Rheumatology, 34A, Kashirskoye shosse, Moscow, 115522, Russian Federation
  • Tatyana Panafidina V.A.Nasonova Research Institute of Rheumatology, 34A, Kashirskoye shosse, Moscow, 115522, Russian Federation
  • Galina Lukina A. S.Loginov Moscow Clinical Research and Practical Center Moscow Healthcare Department, 86, shosse Enthusiastov, Moscow, 111123, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.414

Abstract

Systemic lupus erythematosus is an autoimmune disease characterized by pathological activation of B- and T-cells, the formation of antinuclear antibodies, and dysregulation of cytokine production. The aim of the work was to study the cytokine profiles in patients with this disease in comparison with the disease activity and levels of antinuclear antibodies when using multiplex immunoassay technology, which has a high analytical sensitivity and provide the possibility of simultaneous determination of a large number of biomarkers. Hyperproduction of chemokines IP-10 and MCP-1, regulated by IFN, was associated with high activity of the disease and increased production of antinuclear antibodies. Various immunological subtypes of systemic lupus erythematosus were identified according to the cytokine profile, which reflects the heterogeneity of this multifactorial disease.

Keywords:

systemic lupus erythematosus, cytokine profile, antinuclear antibodies, SLEDAI-2K, multiplex immunoassay

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References


References

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Published

2020-06-15

How to Cite

Aleksandrova , E., Novikov , A., Verizhnikova, Z. ., Panafidina, T., & Lukina, G. (2020). Multiplex immunoassay of the cytokine profile in systemic lupus erythematosus: Relationship with disease activity and level of antinuclear antibodies. Vestnik of Saint Petersburg University. Medicine, 14(4), 314–317. https://doi.org/10.21638/spbu11.2019.414

Issue

Vol. 14 No. 4 (2019)

Section

Internal medicine

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.