Specifics of Hormonal Status in Combined Dishormonal Pathology of the Uterus and Mammary Glands in Reproductive Age

Mikhail S. Shelygin; Nadezhda S. Guziy; Viktoria S. Kaplitskaya

doi:10.21638/spbu11.2019.204

Авторы

Mikhail S. Shelygin North-Western State Medical University named after I. I. Mechnikov, 41, ul. Kirochnaya, St. Petersburg, 191015, Russian Federation
Nadezhda S. Guziy North-Western State Medical University named after I. I. Mechnikov, 41, ul. Kirochnaya, St. Petersburg, 191015, Russian Federation
Viktoria S. Kaplitskaya North-Western State Medical University named after I. I. Mechnikov, 41, ul. Kirochnaya, St. Petersburg, 191015, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.204

Аннотация

The combined dyshormonal pathology of the uterus and mammary glands represents a great danger to the health of a woman, as well as impairs the quality of life, reduces the reproductive capacity of a woman and leads to premature loss of reproductive function. Steroid hormones play a large role in the regulation of proliferative changes in the uterus and mammary glands. Regulation of target organs, uterus and mammary glands, due to the presence of common mechanisms associated with the presence of the receptor apparatus in the tissues of these organs to sex hormones. The general links of pathogenesis and the high frequency of combined pathology of the uterus and mammary glands are of interest to study not only isolated forms of proliferation, but also the development of a unified systematic approach to the study of this pathology. In recent times, there are opposing views on the role of hormonal dysfunction as a factor in proliferative processes. The management tactics of patients with pathological changes in the mammary gland in various gynecological diseases is an assessment of endocrine status, normalization of hormonal and metabolic disorders, especially when progesterone and cortisol are excreted, testosterone levels are increased, and hyperprolactinemia is affected. Special attention should be paid to patients with menstrual disorders, reproductive health disorders. We believe that the problem of the hyperproliferative processes of the uterus and mammary glands should not be considered only from the perspective of gynecological or mammological practice. This pathology is polymorphic and should have broad interdisciplinary connections with such disciplines as oncology, endocrinology, gastroenterology, psychiatry, therapy, pathomorphology, histology, obstetrics and gynecology. Only by studying all possible links of etiopathogenesis, by combining interdisciplinary communication, it is possible to effectively fight for the quality of patients with a combined pathology of the uterus and mammary glands. Family planning, prevention of unplanned pregnancy, timely implementation of maternity, prevention of miscarriage, the use of modern contraceptives, support for breastfeeding is also of high importance for the prevention of disorders and the preservation, extension of reproductive capabilities, and the prevention of combined dyshormonal pathology of the uterus and breast.

Ключевые слова:

hormonal status, mammary glands hyperplastic processes, endometrial hyperplasia, uterine fibroids, fibrocystic disease of the breast, ovarian dysfunction, especially steroidogenesis, women of reproductive age, hormonal dysfunction, hyperprolactinemia, proliferative breast disease, anovulation, gipoestrogeniya, hyperandrogenism, menstrual cycle

Скачивания

Данные скачивания пока недоступны.

Библиографические ссылки

References

Breast medicine and gynecological diseases, pod red. V. E. Radzinskogo. 2nd ed., rev. and exp. Rus. Ed. Moscow, StatusPraesens Publ., 2017. 352 p. (In Russian)

Silaeva E. A., Shmidt A. A., Gajvoronskih D. I., Timoshkova Yu. L., Anashkina R. I., Atayanc K. M., Varfolomeev D. I. Benign dysplasia of the mammary glands. Modern aspects of the clinic, diagnosis and treatment: A practical guide for physicians. Rus. ed. St. Petersburg, SpecLit Publ., 2018. 78 p. (In Russian)

Adamyan L. V., Andreeva E. N., Artymuk N. V., Belocerkovceva L. D., Bezhenar’ V. F., Gevorkyan M. A.,Gluhov E. Yu., Gus A. I., Dobrohotova Yu. E., Zhordania K. I., Zajrat’yanc O. V., Kozachenko A. V., Kiselev S. I., Kogan E. A., Kuznecova I. V., Kurashvili Yu. B., Levakov S. A., Malyshkina A. I., Mal’ceva L. I., Marchenko L. A., Murvatov K. D., Pestrikova T. Yu., Popov A. A., Protopopova N. V., Samojlova A. V., Sonova M. M., Tihomirov A. L., Tkachenko L. V., Urumova L. T., Filippov O. S., Hashukoeva A. Z., Chernuha G. E., Yarmolinskaya M. I., Yarockaya E. L. Uterine myoma: diagnosis, treatment and rehabilitation. Clinical guidelines for management. Rus. ed. Moscow, Nauchnyj centr akusherstva, ginekologii i perinatologii im. V. I. Kulakova Publ., 2015. 100 p. (In Russian)

Shelygin M. S. Combinated benign pathology of the uterus and mammary glands at women of reproductive age: diagnostics and treatment tactics. Zdorov’e zhenshchiny, 2014, no. 9 (95), p. 158. (In Russian)

Novikova V. A. Risk factors for breast cancer in reproductive age. Akusherstvo i ginekologiya, 2015,no. 10, pp. 27–34. (In Russian)

Kravchenko E. N., Ozherel’eva M. A. The condition of the mammary glands in gynecological diseases (literature review). Mat’ i ditya v Kuzbasse, 2014, no. 2, pp. 19–23. (In Russian)

Popov E. N., Ajvazyan T. A., Aleksandrova L. A., Sudakov D. S., Vorob’eva D. D. Evaluation of functional morphology of myometrium in women of reproductive age with combined proliferative diseases of the uterus and isolated uterine leiomyoma. Eastern European Scientific Journal, 2016, vol. 1, no. 5,pp. 117–123.

Hamoshina M. B., Parenkova I. A. Not to ignore mastopathy — not to allow cancer. A new vector of tactics for mastopathy: active cancer prevention: Informational letter, eds V. E. Radzinskiy, N. I. Rozhkova. Rus. ed. Moscow, StatusPraesens Publ., 2015. 24 p. (In Russian)

Vysockaya I. V., Letyagin V. P., Cherenkov V. G., Laktionov K. P., Bublikov I. D. Clinical guidelines of the Russian society of oncomammologists for the prevention of breast cancer, differential diagnosis, treatment of precancerous and benign breast diseases. Opukholi zhenskoj reproduktivnoj sistemy, 2016, vol. 12, no. 3, pp. 43–52. (In Russian)

Akhtamova D. A. Optimization of the management of pregnant women with uterine myoma in the second trimester of pregnancy: dissertation. Rus. ed. Samarkand, 2015. 87 p. (In Russian)

A national gynecology guide, eds G. M. Savelyeva, G. T. Sukhikh, V. N. Serova et al. 2nd ed., rev. and exp.Moscow, GEOTAR-Media Publ., 2017. 1008 p. National guides. (In Russian)

Collins L. C., Aroner S. A., Connolly J. L., Colditz G. A., Schnitt S. J., Tamimi R. M. Breast cancer risk by extent and type of atypical hyperplasia: An update from the Nurses’ Health Studies. Cancer, 2016, vol. 122, no. 4, pp. 515–520.

Bespalov V. G., Travina M. L. Fibrocystic disease and breast cancer risk (а review of literature). Opukholi zhenskoj reproduktivnoj sistemy, 2015, vol. 11, no. 4, pp. 58–70. (In Russian)

Semiglazov V. F., Semiglazov V. V. Breast cancer: biology, local and systemic treatment. Rus. ed. Moscow,SIMK Publ., 2014. 352 p. (In Russian)

Cuzick J., Sestak I., Thorat M. A. Impact of preventive therapy on the risk of breast cancer among women with benign breast disease. Breast, 2015, vol. 24, suppl. 2, pp. S51–S55.

Kataria K., Dhar A., Srivastava A., Kumar S., Goyal A. A systematic review of current understanding and management of mastalgia. Indian J. Surg., 2014, vol. 76, no. 3, pp. 217–222.

Cuzick J., Sestak I., Forbes J. F., Dowsett M., Knox J., Cawthorn S., Saunders C., Roche N., Mansel R. E., von Minckwitz G., Bonanni B., Palva T., Howell A. Anastrozole for prevention of breast cancer in highrisk postmenopausal women (IBIS-II): аn international, double-blind, randomised placebo-controlled trial. Lancet, 2014, vol. 383, no. 9922, pp. 1041–1048.

Bilal I., Chowdhury A., Davidson J., Whitehead S. Phytoestrogens and prevention of breast cancer: The contentious debate. World J. Clin. Oncol., 2014, vol. 5, no. 4, pp. 705–712.

The state of cancer care to the population of Russia in 2016, eds A. D. Kaprin, V. V. Starinskiy, G. V. Petrova. Moscow, MNIOI im. P. A. Gercena — filial NMICR Minzdrava Russia Publ., 2017. 236 p. (In Russian)

Guide to outpatient-polyclinic care in obstetrics and gynecology, eds V. N. Serova, G. T. Sukhikh, V. N. Prilepskaya, V. E. Radzinskiy. 3rd ed., rev. and exp. Moscow, GEOTAR-Media Publ., 2016. 1136 p. (In Russian)