Prolactin and autoimmunity in silicone mammoplasty*

Authors

  • Valerii Zolotykh St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Sergei Lapin Pavlov First Saint Petersburg State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation
  • Anton Gvozdetsky St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Anna Kim St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Тimur Dzhumatov St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Sofia Shaabani St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0001-8472-8557
  • Ekaterina Starovoitova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0002-7240-5010
  • Liya Mikhailova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Pavlov First St. Petersburg State Medical University, 6–8, L’va Tolstogo ul., St. Petersburg, 197022, Russian Federation
  • Мargarita Vishnepol’skaya St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Leonid Churilov St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ;St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation
  • Piotr Yablonskiy St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ;St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.434

Abstract

The article is devoted to the study of the effect of silicone as an adjuvant on the development of autoimmune complications of mammoplasty and the development of autoimmune syndrome induced by adjuvants “ASIA”. This controlled cohort prospective non-randomized research is based on analysis of clinical observations of 121 patients undergoing plastic surgery on the mammary glands for aesthetic purposes, as well for reconstructive and oncological indications, both with and without silicone implants. To obtain preliminary results and evaluate the study, 27 blood serum samples were randomly selected, in which the dynamics of prolactin levels and autoantibody profiles towards 7 common autoantigens were studied before and after 3 and 6 months post-surgery. It was found that 5 out of 27 patients after mammoplasty showed an increase in 2 types of autoantibodies (against modified citrullinated vimentin and annexin V). Patient in need for mammoplasty have increased serum levels of prolactin at the day of operation. After surgery on the mammary gland, the level of prolactin decreases to normal range within 3 months, even if it was significantly higher than normal before surgery. Both of these facts require additional research and analysis on a wider cohorts of patients.

Keywords:

plastic surgery, breast augmentation, breast reconstruction, silicone, autoimmune diseases, autoantibodies, adjuvant, autoimmune inflammatory syndrome induced by adjuvants (ASIA)

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References


References

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Published

2020-06-15

How to Cite

Zolotykh, V. ., Lapin , S. ., Gvozdetsky , A., Kim, A., Dzhumatov Т., Shaabani , S. ., … Yablonskiy , P. . (2020). Prolactin and autoimmunity in silicone mammoplasty*. Vestnik of Saint Petersburg University. Medicine, 14(4), 388–393. https://doi.org/10.21638/spbu11.2019.434

Issue

Vol. 14 No. 4 (2019)

Section

Surgery

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.

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