On the status of autoimmunity in the disorders of schizophrenic and depressive spectra*

Authors

  • Boris Butoma V.M.Bekhterev National Medical Research Center for Psychiatry and Neurology, 3, ul. Bekhtereva, St. Petersburg, 192019, Russian Federation ;St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0003-3577-683X
  • Natalia Petrova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Margarita Mayorova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.406

Abstract

The immunopathological process is known to be a typical facet for many disorders of the nervous system. In this study, quantitative and functional parameters were used to assess the immune system status in patients with schizophrenia, affective disorders, organic brain diseases with psychotic disorders, and multiple sclerosis. The results confirm the possible role of autoimmune reactions in the structure of the pathogenesis of endogenous mental disorders. The immunological profiles in schizophrenia and affective disorders were very similar. Patients with later onset of schizophrenia have shown higher levels of C-reactive protein. It may
indicate its important role in the development of schizophrenia in this particular group of patients. Also, patients with schizophrenia having higher levels of neuron-specific enolase and C-reactive protein suffered from more severe thinking impairment.

Keywords:

autoimmunity, schizophrenic disorders spectrum, depressive disorders spectrum, neuron-specific antigens, galactocerebrosides, S-100 protein, neuron-specific enolase, glial fibrillary acidic protein

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References


References

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Pathmanandavel K., Starling J., Dale R.C., Brilot F. Autoantibodies and the immune hypothesis in psychotic brain diseases: challenges and perspectives. Clinical and Developmental Immunology (Hindawi Publ. Corp), 2013, vol. 2013, Article ID 257184. http://dx.doi.org/10.1155/2013/257184.>

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Durbano F. (Ed.). Psychotic Disorders. Università degli Studi di Milano. Intech Open, 2018, pp. 148–162.>

Butoma B.G., Mazo G.E., Dubinina E.E., Nikiforova Yu. S. Role of an immune inflammation in mechanisms of formation of depression at schizophrenia.Psihicheskoe zdorov’e,2016, no. 10, pp 36–49.(In Russian)>

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Published

2020-06-15

How to Cite

Butoma, B. ., Petrova, N. ., & Mayorova , M. (2020). On the status of autoimmunity in the disorders of schizophrenic and depressive spectra*. Vestnik of Saint Petersburg University. Medicine, 14(4), 284–287. https://doi.org/10.21638/spbu11.2019.406

Issue

Vol. 14 No. 4 (2019)

Section

Neurology. Neurosurgery. Psychiatry

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.