The human placenta and aneuploidy — trisomies 21, 18, 13

Authors

  • Andrey Kolobov St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Anna Lychyova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Vadim Karev Pediatric Research and Clinical Center for Infectious Diseases, 9, ul. Prof. Popova, St. Petersburg, 197022, Russian Federation
  • Oksana Kolobova St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2020.103

Abstract

The purpose of this research was to investigation the morphological features of human placenta with karyotyped trisomy 21, 18 and 13 chromosomes. The study included 50 placenta of fetuses in miscarriages pregnancy at 19–20 weeks, among them 10 placentas obtained as a result of induced abortions due to karyotyped trisomy 21 of the fetuses; 10 placentas obtained as a result of induced abortions due to karyotyped trisomy 18 of the fetuses; 10 placentas obtained as a result of induced abortions due to karyotyped trisomy 13 in the fetuses; 20 placentas obtained as a result of spontaneous miscarriages without any congenital defects and abnormal karyotype of the fetuses. As a result of the investigation, in placentas with karyotyped trisomies, a violation of villi branching was noted. With karyotyped trisomy 21, inhibition of angiogenesis and sclerosis of villi with proliferation of fibroblasts were revealed. In cells of chorionic villi with karyotyped trisomy 18, increased apoptosis was noted. In placentas with karyotyped trisomy 13 hydropic
changes in villus stroma and inhibition of angiogenesis were noted. As a result of the study, in placentas with karyotyped trisomies, a violation of villi branching was noted. With karyotyped trisomy 21, inhibition of angiogenesis and sclerosis of villi with proliferation of fibroblasts were revealed. In cells of chorionic villi with karyotyped trisomy 18, increased apoptosis was noted. In placentas with karyotyped trisomy 13 hydropic changes in villus stroma and inhibition of angiogenesis were noted.

Keywords:

trisomy, placenta, immunohistochemical analysis, angiogenesis, apoptosis

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References


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Published

2020-11-18

How to Cite

Kolobov, A., Lychyova , A. ., Karev, V., & Kolobova, O. (2020). The human placenta and aneuploidy — trisomies 21, 18, 13. Vestnik of Saint Petersburg University. Medicine, 15(1), 24–31. https://doi.org/10.21638/spbu11.2020.103

Issue

Vol. 15 No. 1 (2020)

Section

Internal medicine

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.