ТКАНЕВЫЕ МАТРИЦЫ КЛАПАНОВ СЕРДЦА: СОСТОЯНИЕ ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ

Павел Петрович Яблонский; Сергей Чеботарь; Игорь Тудорахе; Аксель Хаверих

doi:10.21638/11701/spbu11.2016.206

Authors

Павел Петрович Яблонский St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Hannover Medical School, Department of Cardiothoracic, Transplantation and Vascular Surgery, Carl-Neuberg Str., 1, 30625, Hannover OE 6210
Сергей Чеботарь Hannover Medical School, Department of Cardiothoracic, Transplantation and Vascular Surgery, Carl-Neuberg Str., 1, 30625, Hannover OE 6210
Игорь Тудорахе Hannover Medical School, Department of Cardiothoracic, Transplantation and Vascular Surgery, Carl-Neuberg Str., 1, 30625, Hannover OE 6210
Аксель Хаверих Hannover Medical School, Department of Cardiothoracic, Transplantation and Vascular Surgery, Carl-Neuberg Str., 1, 30625, Hannover OE 6210

DOI:

https://doi.org/10.21638/11701/spbu11.2016.206

Abstract

The first successful aortic and mitral valve replacement was performed, respectively, by D. Harken and N. Braunwald in 1960. Both used mechanical graft s, but 10 years later M. Ionescu implanted a biological valve substitute in humans. As biological valve graft s evolved, multiple sources were used: porcine aortic valves, xenopericardial substitutes, and, most recently, tissue engineered allograft s, reseeded by means of guided repopulation. Th e present work describes the major challenges of these methods, analyses diff erent decellularization approaches used for semilunar valves, and future possibilities for tissue engineering to be applied in humans, such as creation of atrioventricular valve substitutes. Refs 73. Figure 1.

Keywords:

tissue engineering, guided regeneration, decellularization, decellularized heart valve, tissue matrix

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References

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