CEREBRO-VISCERAL MALFUNCTIONS IN ACUTE STROKE PATIENTS WITH METABOLIC SYNDROME
DOI:
https://doi.org/10.21638/11701/spbu11.2017.309Abstract
This review examines clinical and pathophysiological aspects of internal organ diseases; in particular, poststroke heart and renal disturbances are discussed. Progression of cerebral-cardiac syndrome can be described as the emergence of ischemic and arrhythmic changes because of autonomic imbalance and catecholamine cytotoxicity in previously intact myocardium. Change in renal functional state can be explained with activation of proinflammatory cytokines, the sympathetic nervous system, and also
hypothalamic-pituitary disturbances through the interaction of the nervous, endocrine, and autacoid system. The article argues for the principal role of microangiopathy as a systemic process, taking place in metabolic syndrome and resulting in polyorganic insufficiency with major dysfunction of the brain, heart and kidney. Diagnostics of microangiopathy in one of these organs can predict stroke and other vascular diseases. Refs 44. Table 1.
Keywords:
Stroke, cerebral-cardiac syndrome, renal insufficiency, microangiopathy, metabolic syndrome
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Литература
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Hudetz A. G., Wood J. D., Kampine J. P. Nitric oxide syntase inhibitor augments post-ischemic leucocyte adhesion in the cerebral microcirulation in vivo. Neurol. Res., 1999, vol. 21, pp. 378–384.
Lavara G., Pueyo M. E., Philippe M., Mandet C., Savoie F., Henrion D., Michel J. B. Chronic blokade of NO syntase activity induces: A proinflammatory phenotype in the arterial wall: prevention by angiotensin II antagonism. Arterioscler. Thromb. Vasc. Biol., 1998, vol. 18, pp. 1408–1416.
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does not induce cerebrovascular inflammation. Soc. Neurosci. Abstr., 2000, vol. 26, p. 644.
Boudina S., Abel E. Diabetic cardiomyopathy, causes and effects. Rev. Endocr. Metab. Disord., 2010,vol. 11, no. 1, pp. 31–39.
Trachanas K., Sideris S., Aggeli C. Diabetic Cardiomyopathy: From Pathophysiology to Treatment.Hellenic J. Cardiol., 2014, vol. 55, pp. 411–421.
Published
2017-09-01
How to Cite
Басанцова, Н. Ю., Шишкин, А. Н., Тибекина, Л. М., & Иванов, А. О. (2017). CEREBRO-VISCERAL MALFUNCTIONS IN ACUTE STROKE PATIENTS WITH METABOLIC SYNDROME. Vestnik of Saint Petersburg University. Medicine, 12(3), 289–301. https://doi.org/10.21638/11701/spbu11.2017.309
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Neurology. Neurosurgery. Psychiatry
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Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.
