Auditory brainstem and cognitive evoked potentials in assessment of brain functional status in patients with ischemic stroke

Daria O. Boricheva; Liudmila M. Tibekina; Aleksandr A. Aleksandrov

doi:10.21638/11701/spbu10.2019.103

Authors

Daria O. Boricheva St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Liudmila M. Tibekina St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Aleksandr A. Aleksandrov St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/11701/spbu10.2019.103

Abstract

Current research aimed to investigate informational content of brainstem acoustic evoked potentials (BAEPs) and auditory cognitive event-related potential — mismatch negativity (MMN) in assessment of brain functional status and cognitive functions in patients with ischemic stroke. MMN is a component of auditory event-related potential with peak latency at 100–250 ms, which reflects automatic process of difference detection between stimuli and neurodynamic processes in auditory cortex at pre-attentive stage. Clinical and neurophysiological examination, including registration of BAEPs and MMN was performed for 22 patients (12 — with ischemic stroke in carotid circulation, 10 — without cerebrovascular diseases). According to results obtained using scales of MMSE, FAB, test with 10 words repetition and Schulte tables, patients with IS demonstrated cognitive impairment as compared to control group. During BAEPs examination, functional changes in brainstem were observed (increased latency of wave V and elongation of interpeak intervals III-V on both sides and III–V ipsilaterally) in patients with ischemic stroke. Also they demonstrated increased peak latency and decreased amplitude of MMN. It points at a decline in auditory discrimination accuracy, shortened lifetime of memory traces and deficit in involuntary attention switching and also indicates of cognitive impairment.

Keywords:

ischemic stroke, cognitive impairment, mismatch negativity, acoustic brainstem evoked potentials, auditory evoked potentials

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References

References

World Health Organisation. Cardio-vascular diseases. Fact sheet no. 317, 2015. Available at: http://www.who.int/mediacentre/factsheets/fs317/ru/ (accessed: 30.10.2018). (In Russian)

Suslina Z. A., Varakin Y. Y. Clinical guide to early diagnostics, treatment and prophylaxis of vascular diseases of the brain. 2nd ed. Moscow, MEDpress-inform Publ., 2017. 352 p. (In Russian)

Parfenov V. A., Cherdak M. A., Vakhnina N. V. et al. Cognitive impairments in patients with prior ischemic stroke.Neurology, Neuropsychiatry, Psychosomatics, 2012, vol. 4, iss. 2S, pp. 17–22. https://doi.org/10.14412/2074-2711-2012-2504 (In Russian)

Klimov L. V., Parfenov V. A. Cognitive impairment in the acute period of ischemic stroke.Nevrologicheskii zhurnal, 2006, vol. 11, iss. S1, pp. 53–57. (In Russian)

Näätänen R., Paavilainen P., Rinne T. et al. The mismatch negativity (MMN) in basic research of central auditory processing: A review.Clin Neurophysiol, 2007, vol. 118, pp. 2544–2590.

https://doi.org/10.1016/j.clinph.2007.04.026

Duncan C. C., Barry R. J., Connolly J. F. et al. Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. Clin. Neurophysiol.,2009, vol. 120, pp. 1883–1908https://doi.org/10.1016/j.clinph.2009.07.045

Näätänen R., Sussman E. S., Salisbury D. et al. Mismatch Negativity (MMN) as an Index of Cognitive Dysfunction. Brain Topography,2014, vol. 27, pp. 451–466. https://doi.org/10.1007/s10548-014-0374-6

Garrido M. I., Kilner J. M., Stephan K. E. et al. The mismatch negativity: A review of underlying mechanisms. Clin. Neurophysiol., 2009, vol. 120, pp. 453–463. https://doi.org/10.1016/j.clinph.2008.11.029

Robson H., Cloutman L., Keidel J. L. et al. Mismatch negativity (MMN) reveals inefficient auditory ventral stream function in chronic auditory comprehension impairments.Сortex, 2014, vol. 59, pp. 113–125. https://doi.org/10.1016/j.cortex.2014.07.009

Yevstigneev V. V., Semashko V. V. Characteristics of brainstem evoked potentials and blink reflex in evaluation of cortex in efficiency at hemispheric brain infarction.International neurological journal,2010, vol. 5, no. 35, pp. 40–44. (In Russian)

Zakharov V. V., Voznesenskaya T. G. Neuropshychic disorders: diagnostic tests.5th ed. Moscow, MEDpress-inform Publ., 2016. 320 p. (In Russian)

Cheng C. H., Hsu W. Y., Lin Y. Y. Effects of physiological aging on mismatch negativity:A meta-analysis. International Journal of Psychophysiology,2013, vol. 90, pp. 165–171. https://doi.org/10.1016/j.ijpsycho.2013.06.026

Gnezditskiy V. V., Korepina O. S. Atlas of event-related potentials.Ivanovo, PresSto Publ., 2011. 532 p.(In Russian)

Luck S. J. An Introduction to the Event-Related Potential Technique. 2nd edition. New York, A BradfordBook, 2014. 416 p.

Luria A. R.Basics of neuropsychology.Moscow, Academy Publ., 2004. 384p.(In Russian)

Shubina N. Y., Fridman E. L., Komarova T. G. Contemporary methods of hearing functional diagnostics.Ivanovo, PresSto Publ., 2013. 188 p. (In Russian)

Näätänen R., Kujala T., Kreegipuu K. et al. The mismatch negativity: an index of cognitive decline in neuropsychiatric and neurological diseases and in ageing.Brain,2011, vol. 134, pp. 3435–3453. https://doi.org/10.1093/brain/awr064

Michie P. T., Malmierca M. S., Harms L. et al. The neurobiology of MMN and implications for schizophrenia. Biol. Psychol., 2016, vol. 116, pp. 90–97.

https://doi.org/10.1016/j.biopsycho.2016.01.011

Tsolaki A. C., Kosmidou V., Kompatsiaris I. et al. Brain source localization of MMN and P300 ERPs in mild cognitive impairment and Alzheimer’s disease: a high-density EEG approach.Neurobiol. of Aging,2017, vol. 55, pp. 190–201. https://doi.org/10.1016/j.neurobiolaging.2017.03.025