Овощи и плоды в профилактике и лечении рака в свете доказательной медицины (часть 2)

Виктор Вениаминович Закревский; Владислав Геннадьевич Лифляндский

doi:10.21638/11701/spbu11.2018.109

Authors

Виктор Вениаминович Закревский North-West State Medical University named after I. I. Mechnikov, 41, ul. Kirochnaya, St.-Petersburg, 191015, Russian Federation
Владислав Геннадьевич Лифляндский North-West State Medical University named after I. I. Mechnikov, 41, ul. Kirochnaya, St.-Petersburg, 191015, Russian Federation

DOI:

https://doi.org/10.21638/11701/spbu11.2018.109

Abstract

A survey of existing literature has analyzed the effect of vegetables and fruits on the risk of developing cancer of the prostate, lungs, pancreas, oral cavity, pharynx and larynx, esophagus and stomach, liver and gallbladder, kidneys and urinary bladder and justifies the possibility of their use for the prevention of these diseases and to improve the quality of life of patients with cancer. It has been established that in order to reduce the risk of cancer, it is not so much the use of certain groups of fruits and vegetables that have the most pronounced preventive effect on certain types of cancer, but rather the overall anti-cancer focus of the entire diet, as well as their sufficient intake. Recommended levels of consumption of vegetables vary according to different authors from 240 to 402 grams per day, fruits — from 160 to 460 grams per day, dietary fiber — from 25 grams per day. The drawback of existing norms of consumption is the lack of norms for certain groups of fruits, berries and vegetables. Given the various causes and different mechanisms of the development of individual forms and localizations of malignant tumors, a maximally differentiated approach is needed in the evaluation of both individual products, individual cancer localizations and their varieties within each localization, including the histological type of tumors and also genetic differences. In addition, it is important to conduct research with qualitative design on large contingents, with the exception of systematic and accidental errors, and also taking into account, in the first place, clinically relevant outcomes (mortality and life expectancy of healthy persons, quality of life, metastasis rate, angiogenesis and tumor proliferation in patients etc.), and not only favorable dynamics of laboratory indicators.

Keywords:

vegetables, fruits, berries, prevention and treatment of cancer, evidence-based medicine

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References

Food, Nutrition, Physical Activity, and the Prevention of Cancer: А Global Perspective. Washington, 2007. 517 р.

Diet, Nutrition, Physical Activity, and Prostate Cancer. Washington, 2014. 53 p.

Niclis C., Díaz Mdel P., Eynard A. R., Román M. D., La Vecchia C. Dietary Habits and Prostate Cancer Prevention: A Review of Observational Studies by Focusing on South America.Nutr. Cancer,2012, vol. 64, no. 1, pp. 23–33. doi: 10.1080/01635581.2012.630163.

Diallo A., Deschasaux M., Galan P., Hercberg S., Zelek L., Latino-Martel P., Touvier M. Associations between fruit, vegetable and legume intakes and prostate cancer risk: results from the prospective Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort. Br. J. Nutr., 2016, vol. 115, no. 9, pp. 1579–1585. doi: 10.1017/S0007114516000520.

Mandair D., Rossi R. E., Pericleous M., Whyand T., Caplin M. E. Prostate cancer and the influence of dietary factors and supplements: a systematic review. Nutr. Metabol.,2014, no. 11: 30. doi: 10.1186/1743-7075-11-30.

Van Poppel H., Tombal B. Chemoprevention of prostate cancer with nutrients and supplements.Cancer Management and Research,2011, no. 3, pp. 91–100. doi: 10.2147/CMR.S18503.

Thompson I., Kristal A., Platz E. A. Prevention of Prostate Cancer: Outcomes of Clinical Trials and Future Opportunities. Am. Soc. Clin. Oncol. Educ. Book, 2014, pp. e76–e80. doi: 10.14694/EdBook_AM. 2014.34.e76.

Vance T. M., Su J., Fontham E. T. H., Koo S. I., Chun O. K. Dietary Antioxidants and Prostate Cancer: A Review. Nutr. Cancer, 2013, vol. 65, no. 6, pp. 793–801. doi:10.1080/01635581.2013.806672.

Graff R. E., Pettersson A., Lis R. T., Ahearn T. U., Markt S. C., Wilson K. M., Rider J. R., Fiorentino M., Finn S., Kenfield S. A., Loda M., Giovannucci E. L., Rosner B., Mucci L. A. Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression. Am. J. Clin. Nutr., 2016, vol. 103, no. 3, pp. 851–860. doi: 10.3945/ajcn.115.118703.

Key T. J., Appleby P. N., Travis R. C., Albanes D., Alberg A. J., Barricarte A., Black A., Boeing H., Bueno-de-Mesquita H. B., Chan J. M., Chen C., Cook M. B., Donovan J. L., Galan P., Gilbert R., Giles G. G.,Giovannucci E., Goodman G. E., Goodman P. J., Gunter M. J., Hamdy F. C., Heliövaara M., Helzlsouer K. J., Henderson B. E., Hercberg S., Hoffman-Bolton J., Hoover R. N., Johansson M., Khaw K. T., King I. B., Knekt P., Kolonel L. N., Le Marchand L., Männistö S., Martin R. M., Meyer H. E., Mondul A. M., Moy K. A., Neal D. E., Neuhouser M. L., Palli D., Platz E. A., Pouchieu C., Rissanen H., Schenk J. M., Severi G., Stampfer M. J., Tjønneland A., Touvier M., Trichopoulou A., Weinstein S. J., Ziegler R. G., Zhou C. K., Allen N. E. Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies. Am. J. Clin. Nutr., 2015, vol. 102, no. 5, pp. 1142–1157. doi: 10.3945/ajcn.115.114306.

Brasky T. M., Kristal A. R., Navarro S. L., Lampe J. W., Peters U., Patterson R. E., White E. Specialty Supplements and Prostate Cancer Risk in the VITamins and Lifestyle (VITAL) Cohort.Nutr. Cancer,2011, vol. 63, no. 4, pp. 573–582. doi: 10.1080/01635581.2011.553022.

Hardin J., Cheng I., Witte J. S. Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk. Nutr. Cancer, 2011, vol. 63, no. 6, pp. 860–872. doi: 10.1080/01635581.2011.582224.

Tantamango-Bartley Y., Knutsen S. F., Knutsen R., Jacobsen B. K., Fan J., Beeson W. L., Sabate J., Hadley D., Jaceldo-Siegl K., Penniecook J., Herring P., Butler T., Bennett H., Fraser G. Are strict vegetarians protected against prostate cancer?Am. J. Clin. Nutr., 2016, vol. 103, no. 1, pp. 153–160. doi: 10.3945/ajcn.114.106450.

Adhami V. M., Khan N., Mukhtar H. Cancer Chemoprevention by Pomegranate: Laboratory and Clinical Evidence. Nutr. Cancer, 2009, vol. 61, no. 6, pp. 811–815. doi: 10.1080/01635580903285064.

Hackshaw-McGeagh L. E., Perry R. E., Leach V. A., Qandil S., Jeffreys M., Martin R. M., Lane J. A. A Systematic Review of Dietary, Nutritional, and Physical Activity Interventions for the Prevention of Prostate Cancer Progression and Mortality.Cancer Causes Control, 2015, vol. 26, pp. 1521–1550. doi: 10.1007/s10552-015-0659-4.

Stefani E. D., Deneo-Pellegrini H., Boffetta P., Ronco A. L., Aune D., Acosta G., Mendilaharsu M., Brennan P., Ferro G. Dietary Patterns and Risk of Adenocarcinoma of the Lung in Males: A Factor Analysis in Uruguay.Nutr. Cancer, 2011, vol. 63, no. 5, pp. 699–706. doi: 10.1080/01635581.2011.563033.

Büchner F. L., Bueno-de-Mesquita H. B., Linseisen J., Boshuizen H. C., Kiemeney L. A., Ros M. M., Overvad K., Hansen L., Tjonneland A., Raaschou-Nielsen O., Clavel-Chapelon F., Boutron-Ruault M. C., Touillaud M., Kaaks R., Rohrmann S., Boeing H., Nöthlings U., Trichopoulou A., Zylis D., Dilis V., Palli D., Sieri S., Vineis P., Tumino R., Panico S., Peeters P. H., van Gils C. H., Lund E., Gram I. T., Braaten T., Martinez C., Agudo A., Arriola L., Ardanaz E., Navarro C., Rodríguez L., Manjer J., Wirfält E., Hallmans G., Rasmuson T., Key T. J., Roddam A. W., Bingham S., Khaw K. T., Slimani N., Bofetta P., Byrnes G., Norat T., Michaud D., Riboli E. Fruits and Vegetables Consumption and the Risk of Histological Subtypes of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).Cancer Causes Control, 2010, vol. 21, pp. 357–371. doi: 10.1007/s10552-009-9468-y.

Takata Y., Xiang Y.-B., Yang G., Li H., Gao J., Cai H., Gao Y.-T., Zheng W., Shu X.-O. Intakes of Fruits, Vegetables, and Related Vitamins and Lung Cancer Risk: Results from the Shanghai Men’s Health Study (2002–2009).Nutr. Cancer, 2013, vol. 65, no. 1, pp. 51–61. doi:10.1080/01635581.2013.741757.

Gorlova O. Y., Weng Sh.-F., Hernandez L., Spitz M. R., Forman M. R. Dietary Patterns Affect Lung Cancer Risk in Never Smokers. Nutr. Cancer, 2011, vol. 63, no. 6, pp. 842–849. doi: 10.1080/01635581.2011.589958.

Tasevska N., Sinha R., Kipnis V., Subar A. F., Leitzmann M. F., Hollenbeck A. R., Caporaso N. E. Schatzkin A., Cross A. J. A Prospective Study of Meat, Cooking Methods, Meat Mutagens, Heme Iron, and Lung Cancer Risks. Am. J. Clin. Nutr., 2009, vol. 89, no. 6, pp. 1884–1894. doi:10.3945/ajcn.2008.27272.

World Cancer Research Fund. Washington, 2012. 37 p.

Chuang S.-C., Stolzenberg-Solomon R., Ueland P. M., Vollset S. E., Midttun O., Olsen A. , Tjonneland A., Overvad K., Boutron-Ruault M.-Ch., Morois S., Clavel-Chapelon F., Teucher B., Kaaks R., Weikert C., Boeing H., Trichopoulou A., Benetou V., Naska A., Jenab M., Slimani N., Romieu I., Michaud D. S., Palli D., Sieri S., Panico S., Sacerdote C., Tumino R., Skeie G., Duell E. J., Rodriguez L., Molina-Montes E., Maria Huerta J., Larranaga N., Barricarte Gurrea A., Johansen D., Manjer J., Ye W., Sund M., Peeters P. H. M., Jeurnink S., Wareham N., Khaw K.-T., Crowe F., Riboli E., Bueno-de-Mesquita B., Vineis P. A U-shaped Association between Plasma Folate and Pancreatic Cancer Risk in the European Prospective Investigation into Cancer and Nutrition. Eur. J. Cancer, 2011, vol. 47, no. 12, pp. 1808–1816. doi: 10.1016/j.ejca.2011.02.007.

Stolzenberg-Solomon R. Z., Sheffler-Collins S., Weinstein S., Garabrant D. H., Mannisto S., Taylor Ph., Virtamo J., Albanes D. Vitamin E Intake, A-Tocopherol Status, and Pancreatic Cancer in a Cohort of Male Smokers. Am. J. Clin. Nutr., 2009, vol. 89, no. 2, pp. 584–591. doi: 10.3945/ajcn.2008.26423.

Zhang J., Dhakal I. B., Gross M. D., Lang N. P., Kadlubar F. F., Harnack L. J., Anderson K. E. Physical Activity, Diet, and Pancreatic Cancer: A Population-Based Case-Control Study in Minnesota. Nutr. Cancer, 2009, vol. 61, no. 4, pp. 457–465. doi: 10.1080/01635580902718941.

Bidoli E., Pelucchi C., Polesel J., Negri E., Barzan L., Franchin G., Franceschi S., Serraino D., De Paoli D., La Vecchia D., Talamini R. Fiber Intake and Risk of Nasopharyngeal Carcinoma: A Case-Control Study.Nutr. Cancer, 2013, vol. 65, no. 8, pp. 1157–1163. doi: 10.1080/01635581.2013.828088.

Kula M., Krauze-Baranowska M. Rubus Occidentalis: The Black Raspberry — its Potential in the Prevention of Cancer. Nutr. Cancer, 2016, vol. 68, no. 1, pp. 18–28. doi: 10.1080/01635581.2016.1115095.

Thompson O. M., Beresford S. A. A., Kirk E. A., Vaughan T. L. Vegetable and Fruit Intakes and Risk of Barrett’s Esophagus in Men and Women. Am. J. Clin. Nutr., 2009, vol. 89, no. 3, pp. 890–896. doi: 10.3945/ajcn.2008.26497.

Kubo A., Block G., Quesenberry C. P. Jr., Buffler P., Corley D. A. Effects of Dietary Fiber, Fats, and Meat Intakes on the Risk of Barrett’s Esophagus. Nutr. Cancer, 2009, vol. 61, no. 5, pp. 607–616. doi: 10.1080/01635580902846585.

Navarro Silvera S. A., Mayne S. T., Risch H. A., Gammon M. D., Vaughan T., Chow W. H., Dubin J. A., Dubrow R., Schoenberg J., Stanford J. L., West A. B., Rotterdam H., Blot W. J. Principal Component Analysis of Dietary and Lifestyle Patterns in Relation to Risk of Subtypes of Esophageal and Gastric Cancer. Ann. Epidemiol., 2011, vol. 21, no. 7, pp. 543–550. doi: 10.1016/j.annepidem.2010.11.019.

Orazova G. U., Karp L. L., Dossakhanov A. Kh., Sauyekenova L. N., Zhaksalykova G. B., Bukhanovskaya L. V., Zhylkaydarova A. Zh., Zhapparov E. I. Nekotorye osobennosti obraza zhizni kak prediktory zlokachestvennykh novoobrazovanii verkhnikh otdelov zheludochno-kishechnogo trakta [Some aspects of lifestyle as predictors of malignant neoplasms of upper gastrointestinal tract]. J. Clin. Med. Kaz., 2015, vol. 1, no. 35, pp. 45–50. (In Russian)

Dong L. M., Kristal A. R., Peters U., Schenk J. M. Dietary Supplement Use and Risk of Neoplastic Progression in Esophageal Adenocarcinoma: A Prospective Study. Nutr. Cancer, 2008, vol. 60, no. 1, pp. 39–48. doi: 10.1080/01635580701586762.

Fan Y., Yuan J.-M., Wang R. Gao Y.-T., Yu M. C. Alcohol, Tobacco and Diet in Relation to Esophageal Cancer: The Shanghai Cohort Study. Nutr. Cancer, 2008, vol. 60, no. 3, pp. 354–363. doi: 10.1080/01635580701883011.

Gupta B., Johnson N. W. Emerging and Established Global Life-Style Risk Factors for Cancer of the Upper Aero-Digestive Tract. Asian Pac. J. Cancer Prev., 2014, vol. 15, no. 15, pp. 5983–5991. doi: 10.7314/APJCP. 2014.15.15.5983.

Hajizadeh B., Jessri M., Moasheri S. M., Rad A. H., Rashidkhani B. Fruits and Vegetables Consumption and Esophageal Squamous Cell Carcinoma: A Case-Control Study. Nutr. Cancer, 2011, vol. 63, no. 5, pp. 707–713. doi: 10.1080/01635581.2011.563028.

Vermeulen E., Zamora-Ros R., Duell E. J., Luján-Barroso L., Boeing H., Aleksandrova K., Bueno-de-Mesquita H. B., Scalbert A., Romieu I., Fedirko V., Touillaud M., Fagherazzi G., Perquier F., Molina-Montes E., Chirlaque M. D., Vicente Argüelles M., Amiano P., Barricarte A., Pala V., Mattiello A., Saieva C., Tumino R., Ricceri F., Trichopoulou A., Vasilopoulou E., Ziara G., Crowe F. L., Khaw K. T., Wareham N. J., Lukanova A., Grote V. A., Tjønneland A., Halkjær J., Bredsdorff L., Overvad K., Siersema P. D., Peeters P. H., May A. M., Weiderpass E., Skeie G., Hjartåker A., Landberg R., Johansson I., Sonestedt E., Ericson U., Riboli E., González C. A. Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort. Am. J. Epidemiol., 2013, vol. 178, no. 4, pp. 570–581. doi: 10.1093/aje/kwt026.

Tan H. Z., Lin W. J.,Huang J. Q., Dai M., Fu J. H., Huang Q. H., Chen W. M., Xu Y. L., Ye T. T., Lin Z. Y.,Lin X. S., Cai J. X., Dong Y. H., Luo H. Y., Chen S. H., Huang Y. L., Yang J., Lin A. X., Yuan X. Q., Chen S. Y., Wang K. S., Zhuang C. Y., Wang S. C., Lin L. L., Zou X. F., Song Z. H., Fang X. H., Chen T., Zhang J. H., Li K. Q., Chen L. H., Lin X. P., Lin J. M., Lin J. N., Lin P. L., Chen J. T., Lin K. M., Hong X. C., Wang L. D., Xu L. Y., Li E. M., Zhang J. J. Updated incidence rates and risk factors of esophageal cancer in Nan’ao Island, a coastal high-risk area in southern China. Dis. Esophagus, 2017, vol. 30, no. 1, pp. 1–7. doi: 10.1111/dote.12468.

Kim J. Y., Kwon O. Garlic Intake and Cancer Risk: an Analysis Using the Food and Drug Administration’s Evidence-Based Review System for the Scientific Evaluation of Health Claims. Am. J. Clin. Nutr., 2009, vol. 89, no. 1, pp. 257–264. doi: 10.3945/ajcn.2008.26142.

Guercio V., Galeone C., Turati F., La Vecchia C. Gastric Cancer and Allium Vegetable Intake: A Critical Review of the Experimental and Epidemiologic Evidence. Nutr. Cancer, 2014, vol. 66, no. 5, pp. 757–773. doi: 10.1080/01635581.2014.904911.

Kodali R. T., Eslick G. D. Meta-Analysis: Does Garlic Intake Reduce Risk of Gastric Cancer? Nutr. Cancer, 2015, vol. 67, no. 1, pp. 1–11. doi: 10.1080/01635581.2015.967873.

Woo H. D., Park S., Oh K., Kim H. J., Shin H. R., Moon H. K., Kim J. Diet and Cancer Risk in the Korean Population: A Meta-analysis. Asian Pac. J. Cancer Prev., 2014, vol. 15, no. 19, pp. 8509–8519. doi: 10.7314/APJCP. 2014.15.19.8509.

Hsiung H., Fann J. C., Yen A. M., Chen S. L.-Sh., Chiu Sh. Y.-H., Ku T.-H., Liu T.-U., Chen H.-H., Lin M.-W. Stage-specific Dietary Factors Associated with the Correa Multistep and Multifactorial Process of Human Gastric Carcinogenesis. Nutr. Cancer, 2016, vol. 68, no. 4, pp. 598-610. doi: 10.1080/01635581.2016.1156712.

Shu L., Wang X. Q., Wang S. F., Wang S., Mu M., Zhao Y., Sheng J., Tao F. B. Dietary Patterns and Stomach Cancer: A Meta-Analysis. Nutr. Cancer, 2013, vol. 65, no. 8, pp. 1105–1115. doi: 10.1080/01635581.2013.828086.

Duell E. J., Lujan-Barroso L., Llivina C., Muñoz X., Jenab M., Boutron-Ruault M.-Ch., Clavel-Chapelon F., Racine A., Boeing H., Buijsse B., Canzian F., Johnson Th., Dalgård Ch., Overvad K., Tjønneland A., Olsen A., Sánchez, Sánchez-Cantalejo E., Huerta J.-M., Ardanaz E., Dorronsoro M., Khaw K.-T., Travis R. C., Trichopoulou A., Trichopoulos D., Rafnsson S., Palli D., Sacerdote C., Tumino R., Panico S., Grioni S., Bueno-de-Mesquita H. B., Ros M. M., Numans M. E., Peeters P. H., Johansen D., Lindkvist B., Johansson M., Johansson I., Skeie G., Weiderpass E., Duarte-Salles T., Stenling R., Riboli E., Sala N., González C. A. Vitamin C Transporter Gene (SLC23A1 and SLC23A2) Polymorphisms, Plasma Vitamin C Levels, and Gastric Cancer Risk in the EPIC Cohort. Genes Nutr., 2013, no. 8, pp. 549–560. doi: 10.1007/s12263-013-0346-6.

Raei N., Behrouz B., Zahri S., Latifi-Navid S. Helicobacter Pylori Infection and Dietary Factors Act Synergistically to Promote Gastric Cancer. Asian Pac. J. Cancer Prev., 2016, vol. 17, no. 3, pp. 917–921. doi: 10.7314/APJCP. 2016.17.3.917.

World Cancer Research Fund International. Washington, 2015. 52 p.

Zhou Y., Li Y., Zhou T., Zheng J., Li S., Li H. B. Dietary Natural Products for Prevention and Treatment of Liver Cancer. Nutrients, 2016, vol. 8, no. 36: 156. doi:10.3390/nu8030156.

Diet, Nutrition, Physical Activity and Gallbladder Cancer. Washington, 2015. 28 p.

Diet, Nutrition, Physical Activity and Kidney Cancer. Washington, 2015. 48 p.

Liu B., Mao Q., Wang X., Zhou F., Luo J., Wang C., Lin Y., Zheng X., Xie L. Cruciferous Vegetables Consumption and Risk of Renal Cell Carcinoma: A Meta-Analysis. Nutrition and Cancer, 2013, vol. 65, no. 5, pp. 668–676. DOI: 10.1080/01635581.2013.795980.

Grieb S. M., Theis R. P., Burr D., Benardot D., Siddiqui T., Asal N. R. Food Groups and Renal Cell Carcinoma: Results from a Case-Control Study. J. Am. Diet. Assoc., 2009, vol. 109, no. 4, pp. 656–667. doi: 10.1016/j.jada.2008.12.020.

Diet, Nutrition, Physical Activity and Bladder Cancer. Washington,2015. 36 p.

Al-Zalabani A. H., Stewart K. F. J., Wesselius A., Schols A. M. W. J., Zeegers M. P. Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses. Eur. J. Epidemiol., 2016, vol. 31, no. 9, pp. 811–851. doi: 10.1007/s10654-016-0138-6.

Key T. J., Appleby P. N., Spencer E. A., Travis R. C., Roddam A. W., Allen N. E. Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford). Am. J. Clin. Nutr., 2009, vol. 89 (suppl.), pp. 1620S–1626S. doi: 10.3945/ajcn.2009.26736M.

Appleby P. N., Crowe F. L., Bradbury K. E., Travis R. C., Key T. J. Mortality in vegetarians and comparable nonvegetarians in the United Kingdom. Am. J. Clin. Nutr., 2016, vol. 103, no. 1, pp. 218–230. doi: 10.3945/ajcn.115.119461.

Schwingshackl L., Hoffmann G. Does a Mediterranean-Type Diet Reduce Cancer Risk? Curr. Nutr. Rep., 2016, no. 5, pp. 9–17. doi: 10.1007/s13668-015-0141-7.