Problems of diagnostics and treatment of diffuse — toxic goiter (Graves’ disease)

Saydiganikxodja I. Ismailov; Komila Kh. Khayitboyeva

doi:10.21638/spbu11.2019.202

Авторы

Saydiganikxodja I. Ismailov Tashkent Pediatric Medical Institute, 223, Bogishamol, Tashkent, 100140, Uzbekistan
Komila Kh. Khayitboyeva Urgench branch of Tashkent Medical Academy, 28, Al-Khorazmy, Urgench, 220100 Uzbekistan

DOI:

https://doi.org/10.21638/spbu11.2019.202

Аннотация

The article is devoted to prevalence, contemporary diagnostic methods and treatment of Grave’s disease. Advantages and disadvantages of different treatment options are discussed. The cause of the disease can be environmental conditions, infectious diseases, severe operational intervention, drugs, trauma, especially brain traumas, iodine deficiency and radiation damage of thyroid in iodine deficiency conditions, familial predisposition. The ideal treatment of Graves’ disease should ensure a fairly rapid elimination of clinical symptoms of thyrotoxicosis, return to an euthyroid state, with minimal risk of complications. The relapse rate of the disease can reach up to 80 %, using conservative treatment. The radioiodine ablation is relatively simple, non-invasive, effective and cheap. There are special indications for surgical treatment. Indications for surgical treatment: 1) large goiter (the volume of the thyroid gland is more than 45 ml); 2) frequent recurrences of thyrotoxicosis and failure of the drug and RIT; 3)malignancy of goiter; 4) allergic and toxic (leukopenic) reactions to thyreostatics. Patients with Graves’ disease should referred to a specialized center with multidisciplinary team.

Ключевые слова:

Graves’ disease, diagnostics, treatment, radical therapy, thyroidectomy

Скачивания

Данные скачивания пока недоступны.

Библиографические ссылки

References

Ametov A. S., Kondrat’yeva L. V., Bugova L. A. Graves disease and functional autonomy of the thyroid gland in a region with a slight iodine deficiency. Klinicheskaya i eksperimental’naya tireoidologiya,2011, vol. 7, no. 4, pp. 51–55. (In Russian)

Mel’nichenko G. A., Udovichenko O. V., Shvedova A. Ye. Endocrinology: Typical mistakes of a practitioner.3rd ed. Moscow,Prakticheskaya Meditsina Publ., 2014. 188 p. (In Russian)

Zhang J. Y., Li S. M., Leng J. L., Chen Y. J., Pu J., Li J. M., Pang F. X., Huang Y. H., Nong J., Cen Y. Z., He H., Li R., Wei L. N., He H. Y. Changes of the spectrum on thyroid disease after the ten-year implementation of universal salt iodization in Guangxi Zhuang Autonomous Region. Zhonghua Liu Xing Bing Xue Za Zhi, 2013, no. 34 (10), pp. 970–974.

Troshina Ye. A. On the issue of deficiency and excess of iodine in the human body. Klinicheskaya I eksperimental’naya tireoidologiya, 2010, vol. 6, no. 4, pp. 9–16. (In Russian)

Bel’tsevich D. G., Vanushko V. E. Endocrine surgery — a new old specialty. Endokrinnaya khirurgiya,2015, no. 1, pp. 9–14. http://doi.org/10.14341/serg201519–14 (In Russian)

Dedov I. I., Mel’nichenko G. A., Fadeyev V. V. Endocrinology: a textbook for med. universities. Moscow,GEOTAR-Media Publ., 2008. 430 p. (In Russian)

Kun I., Balarz J., Nasalean A. et al. Iodine deficiency detected through urinary iodine excretion in school — children living in a goiter prevalent regions of County Mures (December 2005). Acta endocrinol.,2006, vol. 2, no. 4, pp. 265–267.

Farkhutdinova L. M., Sharipova Z. F. On the prevalence of Graves disease in Bashkiria. Kazanskiy meditsinskiy zhurnal, 2010, vol. 91, no. 1, pp. 114–116. (In Russian)

Hammerstad S. S., Tauriainen S., Hyoty H. et al. Detection of enterovirus in the thyroid tissue of patients with graves’ disease. J. Med. Virol., 2012, vol. 85, no. 3, pp. 512–518. https://doi.org/10.1002/jmv.23476

Balabolkin M. I., Klebanova Ye. M., Kreminskaya V. M. Fundamental and clinical thyroidology. Moscow,Meditsina Publ., 2007. 816 p. (In Russian)

Rüst C. A., Knechtle B., Rosemann T. Graves’ disease in monozygotic twins — a case report. BMC Endocr. Disord., 2013, vol. 25, no. 13 (1), p. 17. https://doi.org/10.1186/1472–6823–13–17

National Guide “Endocrinology”, ed. by I. I. Dedov, G. A. Mel’nichenko. Moscow, GEOTAR-Media Publ., 2016. 752 p. (In Russian)

Bobylev M. K., Korshunov D. V. Etiology, diagnosis and modern methods of treatment of diffuse toxic goiter.Uspekhi sovremennogo yestestvoznaniya,2011, no. 8, pp. 93-97. (In Russian)

Fadeyev V. V. Diagnosis and treatment of Graves disease.Meditsinskiy sovet, 2014, no. 18, pp. 44–49.(In Russian)

Menconi F., Marccci C., Marino M. Diagnosis and classification of Graves’ disease. Autoimmun Revews, 2014, no. 13, pp. 398–402. https://doi.org/10.1016/j.autrev.2014.01.013

Esposito G. Initial radioiodine administration: when to use it and how to select the dose. Endocrinology and Metabolism Clinics of North America, 2014, no. 43 (2), pp. 385–400.

Lewis A., Atkinson B., Bell P. et al. Outcome of 131I therapy in hyperthyroidism using a 550 MBq fixed dose regimen. Ulster Medical Journal, 2013, no. 82 (2), pp. 85–88.

Clinical guidelines for endocrinology. Ed. by S. I. Ismailova. Moscow, GEOTAR-Media Publ., 2018.985 p. (In Russian)

Cardoso Lu., Rodrigues D., Silva M. et al. Predictive factors of outcomes in radioiodine treatment for Graves’ disease. Endocrine Abstracts, 2016, 41, GP207. https://doi.org/10.1530/endoabs.41.GP207

Sung T. Y., Lee Y. M., Yoon J. H. et al. Long-Term Effect of Surgery in Graves’ Disease: 20 Years Experience in a Single Institution. Int. J. Endocrinol., 2015. http://dx.doi.org/10.1155/2015/542641

Ismailov S. I., Alimdjanov N. A., Babakhanov B. Kh., Rashitov M. M., Akbutaev A. M. Long-term results after total thyroidectomy in patients with Graves’ Disease in Uzbekistan: retrospective study.World Journal Of Endocrine Surgery, 2011, May — August, no. 3 (2), pp. 79–82.

Shlyakhtich S. L., Antoniv V. R., Vovkanych A. V. To the question of determining the criteria for the volume of surgical intervention for diffuse toxic goiter. Khirurgiya Ukrainy, 2015, no. 1 (53), pp. 47–51.(In Russian)

Woods R. Total thyroidectomy versus bilateral subtotal thyroidectomy in patients with Graves’ diseases: a meta-analysis of randomized clinical trials. Clin. Endocrinol. (Oxf.), 2014, vol. 80, no. 2, p. 316.http://doi.org/10.1111/cen.12231

Adwoa Opoku-Boateng, Wang Tracy S., Sosa Julie Ann. Thyroidectomy in Patients with Graves’ Disease.Graves’ Disease, 2015, pp. 99–113. http://doi.org/10.1007/978-1-4939-2534-6_8

Bojic, T. Paunovic I., Diklic A. et al. Total thyroidectomy as a method of choice in the treatment of Graves’ disease — analysis of 1432 patients. BMC Surgery, 2015, vol. 9, no. 15, p. 39. http://doi.org/10.1186/s12893-015-0023-3

Stathopoulos P., Gangidi S., Kotrotsos G. et al. Graves’ disease: A review of surgical indications, management, and complications in a cohort of 59 patients. Int. J. Oral Maxillofac. Surg., 2015, vol. 44, no. 6, pp. 713–717. http://doi.org/10.1016/j.ijom.2015.02.007

Sakhipov D. R. Differentiated tactics in the surgical treatment of patients with diffuse toxic goiter. PhD diss. Samara, 2016. 155 p. (In Russian)

Feroci F., Rettori M., Borrelli A. et al. A systematic review and meta-analysis of total thyroidectomy versus bilateral subtotal thyroidectomy for Graves’ disease. Surgery, 2014, vol. 155 (3), pp. 529–540. http://doi.org/10.1016/j.surg.2013.10.017

Ritter K., Elfenbein D., Schneider D. F. et al. Hypoparathyroidism after total thyroidectomy: incidence and resolution. Journal Surg. Res., 2015, vol. 197, no. 2, pp. 348–353. http://doi.org/10.1016/j. jss.2015.04.059

Shakh M., Bancos I., Thompson G. B. et al. Teriparatide Therapy and Reduced Postoperative Hospitalization for Postssurgical Hypoparathyroidism. JAMA Otolaryngol. Head Neck Surg., 2015, vol. 141, no. 9, pp. 822–827. http://doi.org/10.1001/jamaoto.2015.1497

Hammerstad S. S., Norheim I., Paulsen T. et al. Excessive Decrease in Serum Magnesium After Total Thyroidectomy for Graves’ Disease Is Related to Development of Permanent Hypocalcemia.World journal of surgery, 2013, vol. 37 (2), pp. 369–375. http://doi.org/10.1007/s00268-012-1843-2

Selberherr A., Scheuba C., Riss P. et al. Postoperative hypoparathyroidism after thyroidectomy:efficient and cost-effective diagnosis and treatment. Surgery, 2015, vol. 157, no. 2, pp. 349–353. http://doi.org/10.1016/j.surg.2014.09.007

Gotovyakhina T. V. Causes of voice impairment after surgical treatment of diseases of the thyroid gland. Rossiyskaya otorinolaringologiya, 2014, no. 1, pp. 45–48. (In Russian)

Kharnas S. S., Ippolitov L. I., Nasimov B. T. et al. Prevention of damage to the recurrent laryngeal nerves during operations on the thyroid gland. Vrach,2015, no. 5, pp. 22–26. (In Russian)

Christou N., Mathonnet M. Complications after total thyroidectomy. J. Visc. Surg., 2013, vol. 150,pp. 249–256. http://doi.org/10.1016/j.jviscsurg.2013.04.003

Yemel’yanova A. M., Valeyeva A. R. Analysis of postoperative complications in the resection of the thyroid gland: paresis, laryngeal paralysis. Uspekhi yestestvoznaniya, 2011, no. 8. 103 p. (In Russian)

Il’icheva Ye.A., Shpakova Ye.A., Roy T. A. et al. Features of the larynx paresis after surgical treatment of diffuse toxic goiter (prospective longitudinal passive study).Vestnik otorinolaringologii, 2011, no. 3,pp. 51–54. (In Russian)

Ismailov S. I., Akbutayev A. M., Elov A. A. The quality of life of patients during treatment with thyroxine and a combination of thyroxine and triiodothyronine after total thyroidectomy due to illness. Mezhdunarodnyy endokrinologicheskiy zhurnal, 2014, vol. 61, no. 5, pp. 43–48. (In Russian)

Kurikhara K. H. Surgical treatment of Graves disease: supersubtotal resection of the thyroid gland.Vestnik khirurgii, 2006, vol. 165, no. 3, pp. 28–30. (In Russian)

Ross D. S., Burch H. B., Cooper D. S. et al. American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid, 2016, no. 26 (10),pp. 1343–1421. http://doi.org/10.1089/thy.2016.0229