Genetic markers of predisposition to monogenic and polygenic obesity

Authors

  • Viktoriia Krasnoborodko Kuban State Medical University, 4, ul. Mitrofana Sedina, Krasnodar, 350063, Russian Federation
  • Seda Bashirova Russian University of Medicine, 4, ul. Dolgorukovskaya, Moscow, 127006, Russian Federation
  • Daria Remizova N. I. Pirogov Russian National Research Medical University, 1, ul. Ostrovityanova, Moscow, 117997, Russian Federation https://orcid.org/0009-0004-5154-5067
  • Aleksandr Reger N. I. Pirogov Russian National Research Medical University, 1, ul. Ostrovityanova, Moscow, 117997, Russian Federation https://orcid.org/0009-0006-0996-8271
  • Daria Osipova Chuvash State University named after I. N. Ulyanova, 15, Moskovsky pr., Cheboksary, 428015, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2024.303

Abstract

Genetic markers of obesity play a crucial role in understanding the pathogenesis of this multifactorial disease, which remains one of the major public health challenges of the 21st century. In recent years, numerous genetic variants associated with obesity have been identified thanks to the development of genome-wide association studies (GWAS). Among the most studied genes are FTO, MC4R, TMEM18, NEGR1, and BDNF. Polymorphisms in these genes are linked to various aspects of appetite regulation, metabolism, and fat tissue accumulation.
It is important to note that the integration of data from genome-wide association studies, epigenetic research, and the analysis of external factors represents a promising direction for the development of personalized strategies for the prevention and treatment of obesity. This comprehensive approach will not only enhance our understanding of the molecular mechanisms underlying obesity but also lead to more effective and targeted therapeutic methods that take into account the individual genetic and epigenetic characteristics of patients.

Keywords:

obesity, genetic markers, metabolism, FTO, MC4R, GWAS, body mass index, adipogenesis, insulin, polygenic variants

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References

Литература

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Published

2025-01-22

How to Cite

Krasnoborodko, V., Bashirova, S., Remizova , D., Reger, A., & Osipova , D. (2025). Genetic markers of predisposition to monogenic and polygenic obesity. Vestnik of Saint Petersburg University. Medicine, 19(3), 218–233. https://doi.org/10.21638/spbu11.2024.303

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Vol. 19 No. 3 (2024)

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Internal medicine

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Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.