Organized activity of canine ventricular fibrillation under reperfusion after 1-minute ischemia of the heart

Authors

  • Marat Gurianov St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Piotr Yablonsky St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2023.203

Abstract

Ventricular fibrillation is the most common cause of sudden cardiac death and continues to be an urgent problem. The aim of the paper was to study the organized activity of canine ventricular fibrillation under 1-minute ischemia and 10-minute reperfusion of the heart. A ventricular electrogram was recorded and spectral analysis of 10-second segments of the electrogram was performed under perfusion, ischemia, and reperfusion of the heart in fibrillation using Fast Fourier Transform at 30 frequencies in the range of 0.5–15 Hz. Specific gravity of 0.5–15-Hz oscillations was determined under perfusion, ischemia, and reperfusion in fibrillation. Ventricular fibrillation is characterized by organized activity during perfusion, ischemia, and reperfusion as evidenced by dominant frequency structure. Perfusion of the heart during ventricular fibrillation increases the stability of the organized structure of fibrillation to ischemia: under 1-minute ischemia after 10-minute perfusion, the frequency of dominant oscillations decreases by only 0.5 Hz while organized activity does not decrease. Reperfusion in fibrillation is characterized by the transient 1.5-Hz increase of frequency of dominant oscillations and by a 15 % decrease of organized fibrillation activity at the 1st minute of reperfusion after 1 minute of ischemia. The organized structure of fibrillation is more sensitive to reperfusion than to ischemia.

Keywords:

ventricular fibrillation, organized activity of fibrillation, heart perfusion, heart ischemia, heart reperfusion, organized activity of ventricular fibrillation, reperfusion complications

Downloads

Download data is not yet available.
 

References

Литература

Лебедев Д. С., Михайлов Е. Н., Неминущий Н. М., Голухова Е. З., Бабокин В. Е., Березницкая В. В.,Васичкина Е. С., Гарькина С. В., Голицын С. П., Давтян К. В., Дупляков Д. В., Заклязьминская Е. В.,Зенин С. А., Иваницкий Э. А., Ильдарова Р. А., Комолятова В. Н., Костарева А. А., Кучинская Е. А.,Лайович (Нестеренко) Л. Ю., Лебедева В. К., Любимцева Т. А., Макаров Л. М., Мамчур С. Е., Медведев М. М., Миронов Н. Ю., Митрофанова Л. Б., Попов С. В., Ревишвили А. Ш., Рзаев Ф. Г., Романов А. Б., Татарский Р. Б., Термосесов С. А., Уцумуева М. Д., Харлап М. С., Царегородцев Д. А.,Школьникова М. А., Шлевков Н. Б., Шляхто Е. В., Шубик Ю. В., Яшин С. М. Желудочковые нарушения ритма. Желудочковые тахикардии и внезапная сердечная смерть. Клинические рекомендации 2020 // Российский кардиологический журнал. 2021. Т. 26, № 7. C. 128–189. https://doi.org/10.15829/1560-4071-2021-4600.

Hayashi M., Shimizu W., Albert C. M. The spectrum of epidemiology underlying sudden cardiac death// Circ. Res. 2015.Vol. 116, no. 12. Р. 1887–1906.

Гурьянов М. И., Яблонский П. К. Стационарные колебания организованной активности фибрилляции желудочков сердца собаки // Вестник Санкт-Петербургского университета. Медицина. 2022. Т. 17, вып. 2. С. 101–108. https://doi.org/10.21638/spbu11.2022.203.

Гурьянов М. И., Яблонский П. К. Метод мониторинга частотно-амплитудных параметров фибрилляции желудочков при искусственной перфузии сердца // Медицинская техника. 2020.№ 5. С. 19–21.

Гурьянов М. И. Доминантная и бездоминантная структура фибрилляции желудочков собаки с ишемией миокарда до фибрилляции // Бюл. экспер. биол. 2016. Т. 161, № 2. С. 186–189.

Li L., Zheng X., Dosdall D. J., Huang J., Pogwizd S. M., Ideker R. E. Long-duration ventricular fibrillation exhibits 2 distinct organized states // Circ. Arrhythm. Electrophysiol. 2013. Vol. 6. P. 1192–1199.

Baehr A., Klymiuk N., Kupatt C. Evaluating novel targets of ischemia reperfusion injury in pig models// Int. J. Mol. Sci. 2019. Vol. 20. P. 4749. https://doi.org/10.3390/ijms20194749.

Jennings R. B. Historical perspective on the pathology of myocardial ischemia/reperfusion injury// Circ. Res. 2013. Vol. 113. P. 428–438. https://doi.org/10.1161/CIRCRESAHA.113.300987.

Masse S., Farid T., Dorian P., Umapathy K., Nair K., Asta J., Ross H., Rao V., Sevaptsidis E., Kumaraswamy N. Effect of global ischemia and reperfusion during ventricular fibrillation in myopathic human hearts // Am. J. Physiol. 2009. Vol. 297. P. H1984–H1991. https://doi.org/10.1152/ajpheart.00101.2009.

Bradley C. P., Clayton R. H., Nash M. P., Mourad A., Hayward M., Paterson D. J., Taggart P. Human ventricular fibrillation during global ischemia and reperfusion. Paradoxical changes in activation rate and wavefront complexity // Circ. Arrhythm. Electrophysiol. 2011. Vol. 4. P. 684–691. https://doi.org/10.1161/circep.110.961284.

Gebhard M. M., Bretschneider H. J., Schnabel P. A. Cardioplegia: principles and problems // Physiology and pathophysiology of the heart. Boston: Kluwer Academic Publishers, 1989. P. 655–669.

Langendorff O. Untersuchungen am uberlebenden Saugethierherzen // Pflüg. Arch. 1895. Vol. 61.P. 291–332.

The R Project for Statistical Computing. URL: https://www.r-project.org/ (дата обращения:20.03.2023).


References

Lebedev D. S., Mikhailov E. N., Neminuschiy N. M., Golukhova E. Z., Babokin V. E., Bereznitskaya V. V.,Vasichkina E. S., Garkina S. V., Golitsyn S. P., Davtyan K. V., Duplyakov D. V., Zaklyazminskaya E. V., Zenin S. A., Ivanitsky E. A., Ildarova R. A., Komolyatova V. N., Kostareva A. A., Kuchinskaya E. A., Lajovich (Nesterenko) L. Yu., Lebedeva V. K., Lyubimtseva T. A., Makarov L. M., Mamchur S. E., Medvedev M. M., Mironov N. Yu., Mitrofanova L. B., Popov S. V., Revishvili A. S., Rzayev F. G., Romanov A. B.,Tatarsky R. B., Termosesov S. A., Utsumueva M. D., Kharlap M. S., Tsaregorodtsev D. A., Shkolnikova M. A., Shlevkov N. B., Shlyakhto E. V., Shubik Yu. V., Yashin S. M. Ventricular arrhythmias. Ventricular tachycardias and sudden cardiac death. 2020 Clinical guidelines. Russian Journal of Cardiology,2021, vol. 26, no. 7, pp. 128–189. https://doi.org/10.15829/1560-4071-2021-4600. (In Russian)

Hayashi M., Shimizu W., Albert C. M. The spectrum of epidemiology underlying sudden cardiac death. Circ. Res., 2015, vol. 116, no. 12, pp. 1887–1906.

Gurianov M. I., Yablonsky P. K. Stationary fluctuations of organized activity of ventricular fibrillation of the canine heart. Vestnik of Saint Petersburg University. Medicine, 2022, vol. 17, issue 2, pp. 101–108.https://doi.org/10.21638/spbu11.2022.203. (In Russian)

Gurianov M. I., Yablonsky P. K. Monitoring the frequency and amplitude parameters of ventricular fibrillation during artificial perfusion of the heart. Biomed. Eng., 2021, vol. 54, pp. 323–326. https://doi.org/10.1007/s10527-021-10031-z. (In Russian)

Guryanov M. I. Dominant and non-dominant structure of ventricular fibrillation in canine heart. Bulletin of Experimental Biology and Medicine, 2016, vol. 160, no. 3, pp. 291–294. (In Russian)

Li L., Zheng X., Dosdall D. J., Huang J., Pogwizd S. M., Ideker R. E. Long-duration ventricular fibrillation exhibits 2 distinct organized states. Circ. Arrhythm. Electrophysiol., 2013, vol. 6, pp. 1192–1199.

Baehr A., Klymiuk N., Kupatt C. Evaluating novel targets of ischemia reperfusion injury in pig models.Int. J. Mol. Sci., 2019, vol. 20, p. 4749. https://doi.org/10.3390/ijms20194749.

Jennings R. B. Historical perspective on the pathology of myocardial ischemia/reperfusion injury. Circ.Res., 2013, vol. 113, pp. 428–438. https://doi.org/10.1161/circresaha.113.300987.

Masse S., Farid T., Dorian P., Umapathy K., Nair K., Asta J., Ross H., Rao V., Sevaptsidis E., Kumaraswamy N. Effect of global ischemia and reperfusion during ventricular fibrillation in myopathic human hearts. Am. J. Physiol., 2009, vol. 297, pp. H1984–H1991. https://doi.org/10.1152/ajpheart.00101.2009.

Bradley C. P., Clayton R. H., Nash M. P., Mourad A., Hayward M., Paterson D. J., Taggart P. Human ventricular fibrillation during global ischemia and reperfusion. Paradoxical changes in activation rate and wavefront complexity. Circ. Arrhythm. Electrophysiol., 2011, vol. 4, pp. 684–691. https://doi.org/10.1161/circep.110.961284.

Gebhard M. M., Bretschneider H. J., Schnabel P. A. Cardioplegia: principles and problems. Physiology and pathophysiology of the heart. Boston, Kluwer Academic Publishers, 1989, pp. 655–669.

Langendorff O. Untersuchungen am uberlebenden Saugethierherzen. Pflüg. Arch., 1895, vol. 61,pp. 291–332.

The R Project for Statistical Computing. Available at: https://www.r-project.org/ (accessed: 20.03.2023).

Downloads

Published

2023-09-29

How to Cite

Gurianov, M. ., & Yablonsky, P. . (2023). Organized activity of canine ventricular fibrillation under reperfusion after 1-minute ischemia of the heart. Vestnik of Saint Petersburg University. Medicine, 18(2), 141–149. https://doi.org/10.21638/spbu11.2023.203

Issue

Vol. 18 No. 2 (2023)

Section

Cardiology

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.