Neurorehabilitation: Sanogenetic and pathogenetic foundations of innovative directions

Authors

  • Lyudmila Tibekina St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Alexander Shaposhnikov St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2021.303

Abstract

The processes of sanogenesis and pathogenesis in patients with acute cerebrovascular accident occur simultaneously, starting with the acute period of stroke. In most cases, this is a single process viewed from different perspectives. Modern innovative areas of neurorehabilitation include the use of drug therapy, rehabilitation measures and mechanisms of sanogenesis and self-healing, which can be influenced by the methods used in the course of restoring the health of neurological patients. The organizational model of modern neurorehabilitation is based on an interdisciplinary multistage approach. The analysis of the relationship between patho‑ and sanogenetic reactions is important for the development of this organizational model. Exogenous therapeutic and rehabilitation measures form a single complex with endogenous factors of sanogenesis. These measures achieve the maximum effect only with the conscious active participation of the patient in the recovery process. The theoretical basis of the research is the concept of the theory of functional systems by P. K. Anokhin and the axiomatic theory of human health. The integration of these approaches is considered as the most general self-acting self-healing mechanism, concretized in the form of the concept of sanogenesis. Mechanisms for maintaining homeostasis are activated at all levels when a damaging factor occurs. Pathogenesis develops, becoming an integral part of the processes of sanogenesis.

Keywords:

rehabilitation, sanogenesis, pathogenesis, theory of functional systems, theory of human health, innovation, stroke

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References


References

Suslina Z. A., Piradov M. A. Stroke: diagnosis, treatment, prevention. 2nd ed. Moscow: MEDpress-inform Publ., 2009. 288 p. (In Russian)

Stakhovskaya L. V., Klochikhina O. A., Bogatyreva M. D., Kovalenko V. V. Epidemiology of stroke in Russia according to the results of the territorial-population register (2009–2010). Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova, 2013, no. 5, pp. 4–10. (In Russian)

Skvortsova V. I., Shetova I. M., Kakorina E. P., Kamkin E. G., Boiko E. L., Alekian B. G., Ivanova G. E., Shamalov N. A., Dashian V. G., Kruglov V. V. The results of the implementation of the “Complex of measures to improve medical care for patients with acute cerebrovascular accidents in the Russian Federation”. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova, 2018, no. 4, pp. 5–12. (In Russian)

Skoromets A. A., Demyanovskaya E. G Drug therapy for neurological patients. Moscow: Medical Information Agency Publ., 2017. 280 p. (In Russian)

Suslina Z. A., Varakin Yu. Ya. Clinical guidelines for the early diagnosis, treatment and prevention of cerebrovascular diseases. 2nd ed. Moscow: MEDpress-inform Publ., 2017. 352 p. (In Russian)

Kim A. S., Cahill E., Cheng N. T. Global stroke belt: Geographic variation in stroke burden worldwide. Stroke, 2015, vol. 46, no. 12, pр. 3564–3570.

Ivanova G. E. Opening remarks. Materialy XII Mezhdunarodnogo Kongressa “Neurorehabilitation 2020”. (In Russian)

Aukhadeev E. I., Ivanova G. E., Bodrova R. A. Methodology of medical rehabilitation based on modern concepts of science about complex self-developing systems. Izbrannye voprosy neiroreabilitatsii, 2015, p. 418. (In Russian)

Shaposhnikov A. N., Shaposhnikov S. A. The theory of human health (Axioms of the theory of human health). Moscow, 2018. 13 р. (In Russian)

Goldman J. A., Poss K. D. Gene regulatory programs of tissue regeneration. Nature Reviews Genetics,2020, vol. 21, pp. 511–525.

Shaposhnikov A. N., Shaposhnikov S. A. Axiomatic theory of human health. Materialy XV Vseros. nauch.-prakt. konf. s mezhdunar. uchastiem «Zdorov’e — osnova chelovecheskogo potentsiala: Problemy i puti ikh resheniia», 2020, pp. 1294–1302. (In Russian)

Medvedev A. S. Fundamentals of Medical Rehabilitation. Minsk: Belarus Nauka Publ., 2010. 434 p. (In Russian)

Goldblat Yu. V. Medical and social rehabilitation in neurology. St. Petersburg: Politekhika Publ., 2006. 607 p. (In Russian)

Gusev E. I., Kryzhanovsky G. N. Dysregulatory pathology of the nervous system. Moscow: Medical Information Agency Publ., 2009. 512 p. (In Russian)

Tibekina L. M., Shevchenko Yu. V., Sergeeva T. V., Avdeev V. V. Medical rehabilitation at the second stage of routing patients with stroke in the Clinic of Rehabilitation Medicine. Materialy konf. «Zdorov’e — osnova chelovecheskogo potentsiala: Problemy i puti ikh resheniia» — Trudy VIII Vseros. nauch.-prakt. konf. s mezhdunar. uchastiem, 2013, pp. 436–438.

Novikova L. B., Akopyan A. P., Sharapova K. M. Rehabilitation of patients in the most acute and acute periods of stroke:textbook. Ufa: FGBOU VO BGMU Minzdrava Rossii Publ., 2019. 75 p. (In Russian)

Nieto-Sampedro M., Nieto-Dias M. Neural plasticity: changes with age. Journal of neural transmission, 2005, vol. 112, pp. 3–27.

Agnati L. F., Guidolin D., Fuxe K. The brain as a system of nested but partially overlapping networks. Heuristic relevance of the model for brain physiology and pathology. Journal of neural transmission,2007, vol. 114, pp. 3–19.

Butefisch C. M. Plasticity in the human cerebral cortex: lessons from the normal brain and from stroke.Neuroscientist, 2004, vol. 10. pp. 163–173.

Ziemann U., Muellbacher W., Hallett M., Cohen L. G. Modulation of practice-dependent plasticity in human motor cortex. Brain, 2001, vol. 124, pp. 1171–1181.

Gusev E. I., Kamchatnov P. R. Plasticity of the nervous system. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova, 2004, pp. 73–79. (In Russian)

Drachman D. A. Aging of the brain, entropy, and Alzheimer disease. Neurology, 2006, vol. 67, pp. 1340–1352.

Gage F. H. Structural plasticity of the adult brain. Dialog. Dialogues in clinical neuroscience, 2004, vol. 6 (2), pp. 135–141.

Ozen I., Boix J., Paul G. Perivascular mesenchymal stem cells in the dult human brain: a future target for neuroregeneration. Clinical and Translational Medicine, 2012, vol. 1, p. 30.

Curtis M. A., Kam M., Faull R. Neurogenesis in humans. European Journal of Neuroscience, 2011, vol. 33, pp. 1170–1174.

Nakatomi H., Kuriu T., Okabe S., Yamamoto S., Hatano O., Kawahara N., Tamura A., Kirino T., Nakafuku M. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell, 2002, vol. 110, pp. 429–441.

Kryzhanovsky G. N. General Pathophysiology of the Nervous System: A Guide. Moscow: Medicina Publ., 1997. 352 p. (In Russian)

Magaeva S. V. Georgy Nikolaevich Kryzhanovsky, scientist and citizen. Moscow: MIOO Publ., 2007. 154 p. (In Russian)

Gusev E. I., Gekht A. B., Gaptov V. B., Tikhopoy E. V. Rehabilitation in Neurology: Textbook. Moscow: GEOTAR-Media Publ., 2000. (In Russian)

Kadykov A. S., Shakhparonova N. V. Rehabilitation after a stroke. Rossiiskii meditsinskii zhurnal, 2003, pp. 1390–1394. (In Russian)

Hachinski V. Stroke: implementing a global agenda II. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova,2007, p. 73. (In Russian)

Nudo R. J., Wise B. M., SiFuentes F., Milliken G. W. Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct. Science, 1996, vol. 272, pp. 1791–1794.

Liepert J., Bauder H., Wolfgang H. R., Miltner W. H., Taub E., Weiller C. Treatment-induced cortical reorganization after stroke in humans. Stroke, vol. 31, pp. 1210–1216.

Lieper T. J. Motor cortex excitability in stroke before and after constrain-induced movement therapy.Cognitive and behavioral neurology: official journal of the Society for Behavioral and Cognitive Neurology,2006, vol. 19 (Suppl. 1), pp. 41–47.

Damulin I. V., Kononenko I. V. Staticolocomotor disorders at patients with hemispheric stroke. Klinicheskaia gerontologiia, 2007, no. 8, pp. 42–49. (In Russian)

Grotta J. C., Noser E. A., Ro T., Boake C., Levin H., Aronowski J., Schallert T. Constraint-induced movement therapy. Stroke, 2004, vol. 35, suppl. 1, pp. 2699–2701.

Tibekina L. M. Early neurorehabilitation in patients with IS of different ages. Materialy konferentsiis mezhd. uchastiem «Biopsikhosotsial’nye podkhody v reabilitatsii bol’nykh», 2015, pp. 83–84. (In Russian)

Tibekina L. M., Basantsova N. Yu. Features of the course of ischemic stroke in persons of different ages. Materialy konferentsii «Aktual’nye voprosy diagnostiki i lecheniia zabolevanii nervnoi sistemy u lits pozhilogo vozrasta», 2015, vol. 5. no. 3, pp. 183–184. (In Russian)

Basantsova N. Yu. Features of cardiovascular disorders in patients in the acute period of ischemic stroke against the background of metabolic syndrome. Diss … cand. medical sciences. St. Petersburg, 2020. 147 р. (In Russian)

Shaposhnikov A. N., Shaposhnikov S. A. Systemic health improvement (a practical guide based on twelve basic health improvement factors). Moscow: Novoe Vremia Publ., 2014. 123 p. (In Russian)

Anokhin P. K. Essays on the physiology of functional systems. Moscow: Medicina Publ., 1975. 477 p. (In Russian)

Sudakov K. V. Systemic construction of human functions. Moscow: INF im. P. K. Anokhina; RAMN Publ., 1999. 15 p. (In Russian)

Basantsova N. Yu., Tibekina L. M., Shishkin A. N. The role of the autonomic nervous system in the development of cerebrocardiac disorders. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova, 2017, vol. 117, no. 11, pp. 153–160. (In Russian)

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Published

2021-09-30

How to Cite

Tibekina, L. ., & Shaposhnikov , A. (2021). Neurorehabilitation: Sanogenetic and pathogenetic foundations of innovative directions. Vestnik of Saint Petersburg University. Medicine, 16(3), 159–170. https://doi.org/10.21638/spbu11.2021.303

Issue

Vol. 16 No. 3 (2021)

Section

Neurology. Neurosurgery. Psychiatry

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.