NK-cells in placenta of female patients with type 1 diabetes mellitus

Анна Дробинцева; Дмитрий Медведев; Ирина Юшкова; Виктория Полякова

doi:10.21638/spbu11.2019.429

Авторы

Анна Дробинцева St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation ; St. Petersburg Medico-Social Institute, 72, Kondrat’evskii pr., St. Petersburg, 195271, Russian Federation
Дмитрий Медведев St. Petersburg Medico-Social Institute, 72, Kondrat’evskii pr., St. Petersburg, 195271, Russian Federation ; St. Petersburg Institute of Bioregulation and Gerontology, 3, pr. Dinamo, St. Petersburg, 197110, Russian Federation
Ирина Юшкова St. Petersburg Medico-Social Institute, 72, Kondrat’evskii pr., St. Petersburg, 195271, Russian Federation
Виктория Полякова St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation ; St. Petersburg Medico-Social Institute, 72, Kondrat’evskii pr., St. Petersburg, 195271, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.429

Аннотация

Placenta is a temporary organ that performs multiple functions to provide a normal course of the intrauterine development of the child. However, immune interactions in placenta are not well understood. Since women with type 1 diabetes mellitus have a greater risk of adverse pregnancy outcomes due to aberrant immunological adaptation, the study of immunological interactions in placenta of these women is of particular interest. In this study a comparative analysis of the age-related expression parameters of marker of NK-cells (CD57) in placenta in patients with type 1 diabetes mellitus was performed. The current study revealed differences in the expression parameters of NK-cells marker between two age subgroups of the patients and compared to healthy controls. The results indicate the high significance of inflammatory type 1 diabetes mellitusmarkers in women with type 1 diabetes mellitus for assessing the course of pregnancy and the possible development of somatic pathology in newborns, especially from older women.

Ключевые слова:

type 1 diabetes mellitus, T1DM, pregnancy, NK-cells, autoimmunity in pregnancy

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Библиографические ссылки

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